Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 108, Issue -, Pages 28-38Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2015.11.024
Keywords
Gallocyanine; Phenoxazine; DKK1 inhibitors; DKK1/LRP6 interaction inhibitors; Tau phosphorylation inhibition; Alzheimer's disease; Tauopathies
Categories
Funding
- European Union
Ask authors/readers for more resources
In search of safe and effective anti-Alzheimer disease agents a series of gallocyanine dyes have been synthesized and evaluated for their ability to inhibit LRPs/DKK1 interactions. Modulation of the interactions between LRPs and DKK1, regulate Wnt signaling pathway and affect Tau phosphorylation. The current efforts resulted in the identification of potent DKK1 inhibitors which are able to inhibit prostaglandin J2-induced tau phosphorylation at serine 396. (C) 2015 Elsevier Masson SAS. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
