Article
Engineering, Biomedical
Huaqing Chen, Lanlan Liu, Aiqing Ma, Ting Yin, Ze Chen, Ruijing Liang, Yuzhi Qiu, Mingbin Zheng, Lintao Cai
Summary: Sonodynamic therapy (SDT) shows promise for tumor treatment by activating immune responses and suppressing tumor growth. A multifunctional nanosonosensitizer system (FA-MnPs) has been developed, demonstrating deep-responsive SDT and immune activation, leading to tumor growth inhibition.
Article
Biochemistry & Molecular Biology
Xiaolan Feng, Chen Wu, Wenhao Yang, Jiayi Wu, Pan Wang
Summary: Due to its noninvasive nature and high tissue penetrating capabilities, ultrasound-driven sonodynamic treatment (SDT) has broad application possibilities in various diseases. However, the inefficient buildup of sonosensitizers in the tumor site significantly impairs the effectiveness of SDT. This study proposes a deep-penetrating sonochemistry nanoplatform for controlled release of reactive oxygen species and drugs, leading to improved chemotherapeutic effectiveness and SDT efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Danling Cheng, Xiaoying Wang, Xiaojun Zhou, Jingchao Li
Summary: Immunotherapy is a promising strategy for cancer treatment, but it faces challenges of low immune responses and immune-related adverse events. Sonodynamic therapy combined with immunotherapy can enhance antitumor immunity, and research on nanosonosensitizers for ROS generation is ongoing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Physical
Lishan Zhang, Ting Yin, Baozhen Zhang, Chong Yan, Chengyu Lu, Lanlan Liu, Ze Chen, Hui Ran, Qingxia Shi, Hong Pan, Aiqing Ma, Lintao Cai
Summary: This study developed a novel sonosensitizer nanoplatform to enhance the efficiency of sonodynamic therapy (SDT) and reduce toxic side effects by targeting recognition and endocytosis.
Article
Chemistry, Multidisciplinary
Qiqing Chen, Min Zhang, Hui Huang, Caihong Dong, Xinyue Dai, Guiying Feng, Ling Lin, Dandan Sun, Dayan Yang, Lin Xie, Yu Chen, Jia Guo, Xiangxiang Jing
Summary: The authors engineered a single copper atom-doped titanium dioxide nanosonosensitizer for synergistic chemodynamic and sonodynamic treatment of triple-negative breast cancer (TNBC). The nanosonosensitizers effectively inhibited TNBC both in vitro and in vivo, providing a therapeutic paradigm for non-invasive and safe tumor elimination using multifunctional single-atom nanosonosensitizers.
Article
Engineering, Biomedical
Wenxin Wu, Ming Xu, Bin Qiao, Tongyi Huang, Huanling Guo, Nan Zhang, Luyao Zhou, Manying Li, Yang Tan, Minru Zhang, Xiaoyan Xie, Xintao Shuai, Chunyang Zhang
Summary: A combination therapeutic strategy integrating STING pathway activation, hypoxia relief, and sonodynamic therapy (SDT) with anti-PD-L1 therapy was reported to improve the therapeutic outcome in triple-negative breast cancer (TNBC). The synthesized nanodroplet released oxygen and promoted SDT to generate cytotoxic reactive oxygen species (ROS), while the co-delivered STING agonist promoted the maturation and tumor antigen cross-presenting of dendritic cells (DCs) for priming of cytotoxic T lymphocytes (CTLs). Additionally, SDT induced immunogenic cell death (ICD) and increased tumor immunogenicity to promote tumor infiltration of CTLs.
ACTA BIOMATERIALIA
(2023)
Review
Medicine, General & Internal
Hyeryeon Choi, Kwangsoon Kim
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. Current treatment options are limited and variable response to chemotherapy exists due to disease heterogeneity. This review discusses FDA-approved targeted therapies for TNBC, as well as novel theranostic approaches using nanocarriers. These approaches aim to improve diagnosis and treatment of TNBC by enabling targeted drug delivery and visualization of the lesion.
Article
Chemistry, Multidisciplinary
Bin Zhao, Zhili Ma, Shuaishuai Ding, Yuhua Cao, Jiangfeng Du, Lijuan Zeng, Yunping Hu, Jingrong Zhou, Xiao Zhang, Xiu-wu Bian, Gan Tian
Summary: Nanomedicine-based synergy of chemodynamic therapy (CDT) and radiotherapy (RT) modulated by tumor microenvironment enables rapid tumor ablation, which holds great hope for the refractory and recurrent cancers, such as triple negative breast cancer (TNBC). The single-component MnWO4 is first reported as a new kind of Fenton-like agent yet radiosensitizer for TNBC treatment undergoing the synergistic CDT/RT mechanism. Mn-triggered chemodynamic effect delays RT-induced DNA damage repair and sorts cell cycles distribution toward radiosensitive phases, while W-mediated radiosensitization improves the tumoral H2O2 overexpression to enhance CDT, remarkably amplifying of the intracellular oxidative stress to boost 4T1 cell apoptosis.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Nicholas J. Lyons, Rabina Giri, Jakob Begun, David Clark, David Proud, Yaowu He, John D. Hooper, Thomas Kryza
Summary: This article discusses the role of reactive oxygen species (ROS) in normal and malignant colonic cell biology and explores how existing and emerging therapies can utilize ROS for therapeutic benefit. Recent research has shed light on the contribution of ROS to the cytotoxicity of conventional chemotherapy, as well as the generation of ROS in response to excitatory stimuli in emerging therapies such as photodynamic therapy, sonodynamic therapy, and radiodynamic therapy. However, the poor prognosis and resistance associated with metastatic colorectal cancer necessitate the development of new and more effective treatments.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Chemistry, Multidisciplinary
Yingbo Li, Jie Yang, Xilin Sun
Summary: Advancements in nanotechnology for cancer therapy have led to the development of nanomaterials that specifically generate cytotoxic reactive oxygen species (ROS) in tumor cells. These materials disturb the redox balance in tumor cells, leading to oxidative damage of DNA and proteins.
FRONTIERS IN CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Abdallah M. Ayoub, Ahmed M. Abdelsalam, Jan Schulze, Muhammad U. Amin, Konrad Engelhardt, Matthias Wojcik, Damiano Librizzi, Behrooz H. Yousefi, Usman Nasrullah, Josef Pfeilschifter, Udo Bakowsky, Eduard Preis
Summary: The application of photodynamic therapy in cancer treatment is crucial, but the lipophilic nature of most photosensitizers hinders their administration and causes aggregation in biological environments. Researchers encapsulated the natural photosensitizer parietin (PTN) in poly(lactic-co-glycolic acid) nanoparticles to overcome this limitation. The PTN nanoparticles displayed a size of 193.70 nm and 157.31 nm as characterized by dynamic light scattering and atomic force microscopy, respectively. The quantum yield and in vitro release of PTN nanoparticles were assessed, along with their effects on triple-negative breast cancer cells and angiogenic blood vessels. The results showed promising anticancer effects and a reduction in angiogenic blood vessels, suggesting that PTN nanoparticles could be an effective strategy for fighting cancer.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Qiyu Liu, Liyin Shi, Ying Liao, Xianshuo Cao, Xiaoqing Liu, Yanxia Yu, Zifan Wang, Xihong Lu, Jianwei Wang
Summary: This study designs ultrathin-FeOOH-coated MnO2 nanospheres as sonosensitizers to enhance the anticancer efficacy of sonodynamic therapy. The nanospheres facilitate ultrasound-triggered reactive oxygen species (ROS) production and modulate the tumor microenvironment. The results show that MO@FHO exhibits high tumor suppression efficacy without obvious toxicity to normal tissues.
Review
Chemistry, Inorganic & Nuclear
Nafees Muhammad, Muhammad Hanif, Piaoping Yang
Summary: Triple-negative breast cancer is an aggressive and hard-to-treat form of breast cancer, which poses an urgent medical need. The lack of receptors makes it challenging to develop more effective targeted therapies. Therefore, the investigation and development of innovative multimodal strategies are needed to target this specific type of breast cancer.
COORDINATION CHEMISTRY REVIEWS
(2024)
Article
Biochemistry & Molecular Biology
Kevin J. Lee, Griffin Wright, Hannah Bryant, Leigh Ann Wiggins, Valeria L. Dal Zotto, Michele Schuler, Christopher Malozzi, Michael Cohen, Natalie R. Gassman
Summary: Vitamin D supplementation reduced Doxorubicin-induced cardiotoxicity by decreasing reactive oxygen species and mitochondrial damage, without compromising the anticancer efficacy of Doxorubicin against TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Engineering, Biomedical
Pallabita Chowdhury, Upasana Ghosh, Kamalika Samanta, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu
Summary: Management of aggressive breast cancer, particularly TNBC, remains challenging despite advances in treatment. New therapies like atezolizumab, olaparib, and sacituzumab show limited survival benefits. Current research aims to improve treatment strategies by enhancing bioavailability, targetability, and reducing toxicity for better therapeutic outcomes.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
