Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 123, Issue -, Pages 141-154Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2016.07.037
Keywords
beta-lonone; Terpenoid derivatives; Anticancer agents; Anti-proliferative activity; Apoptosis; Drug design
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Funding
- Research Council of Mazandaran University of Medical Sciences, Sari, Iran
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beta-lonone is an end-ring analog of beta-carotenoids which widely distributed in fruit and vegetables. Recent studies have demonstrated anti-proliferative, anti-metastatic and apoptosis induction properties of beta-ionone in vitro and in vivo. Also, the studies have focused on investigating the beta-ionone action on different types of malignant cells and the possible mechanisms of action. Moreover, the quest of new synthetic beta-ionone-based compounds possessing anti-proliferative, anti-metastatic and apoptosis induction activities may enable the discovery of compounds which can be used in combination regimes thus overcoming tumor resistance to conventional anticancer agents. These new agents will also be useful for targeting distinct signaling pathways, to activate selectively mechanisms for apoptosis in cancer cells but devoid of undesirable side effects. In this paper, we reviewed the potentialities of beta-ionone and related compounds in cancer prevention and chemotherapy. (C) 2016 Elsevier Masson SAS. All rights reserved.
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