Article
Oncology
Fatima Cardoso, Amelia McCartney, Antonio Ponti, Lorenza Marotti, Conny Vrieling, Alexandru Eniu, Berta Sousa, Carla Ripamonti, Luzia Travado, Sabine Spitz, Eva Jolly, Giuseppe Curigliano, Frederique Penault-Llorca, Frederic Lecouvet, Isabel T. Rubio, Laura Biganzoli
Summary: The European Society of Breast Cancer Specialists and the Advanced Breast Cancer Global Alliance have developed the first set of quality indicators for metastatic breast cancer (MBC) with the aim of ensuring high-quality care and adherence to guidelines in breast cancer centers.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Asma Munir, Anita Huws, Sohail Khan, Yousef Sharaiha, Simon Holt, Saira Khawaja
Summary: This study explores the feasibility and impact of a self-administered geriatric assessment on treatment decision-making in older women with early-stage breast cancer. The results suggest that the assessment can influence treatment recommendations, particularly those related to the significant morbidity that may impact the use of chemotherapy and/or radiotherapy.
Article
Oncology
Lien van Walle, Didier Verhoeven, Lorenza Marotti, Antonio Ponti, Mariano Tomatis, Isabel T. Rubio
Summary: This study utilized the EUSOMA database to analyze data from 56 certified breast centers, revealing significant variations and trends in breast cancer treatment across Europe, demonstrating important differences.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ritse M. Mann, Alexandra Athanasiou, Pascal A. T. Baltzer, Julia Camps-Herrero, Paola Clauser, Eva M. Fallenberg, Gabor Forrai, Michael H. Fuchsjaeger, Thomas H. Helbich, Fleur Killburn-Toppin, Mihai Lesaru, Pietro Panizza, Federica Pediconi, Ruud M. Pijnappel, Katja Pinker, Francesco Sardanelli, Tamar Sella, Isabelle Thomassin-Naggara, Sophia Zackrisson, Fiona J. Gilbert, Christiane K. Kuhl
Summary: Breast density is an independent risk factor for breast cancer and reduces the effectiveness of mammography. Recent studies show that contrast-enhanced breast MRI can significantly reduce breast cancer mortality and is cost-effective for women with extremely dense breasts. Therefore, the European Society of Breast Imaging (EUSOBI) recommends informing women about their breast density and offering screening breast MRI every 2 to 4 years for women aged 50 to 70 with extremely dense breasts.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Torsten O. Nielsen, Samuel C. Y. Leung, David L. Rimm, Andrew Dodson, Balazs Acs, Sunil Badve, Carsten Denkert, Matthew J. Ellis, Susan Fineberg, Margaret Flowers, Hans H. Kreipe, Anne-Vibeke Laenkholm, Hongchao Pan, Friderique M. Penault-Llorca, Mei-Yin Polley, Roberto Salgado, Ian E. Smith, Tomoharu Sugie, John M. S. Bartlett, Lisa M. McShane, Mitch Dowsett, Daniel F. Hayes
Summary: Ki67 immunohistochemistry (IHC) is commonly used in breast cancer as a proliferation marker, but its analytical validity has been questioned. The International Ki67 in Breast Cancer Working Group (IKWG) recommends careful preanalytical handling, adoption of a standardized visual scoring method, and participation in quality assurance and quality control programs. Clinical utility of Ki67 IHC in breast cancer care is currently limited to prognosis assessment in stage I or II breast cancer.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)
Review
Medicine, General & Internal
Domenico Fusco, Alessandro Ferrini, Giuseppe Pasqualetti, Chiara Giannotti, Matteo Cesari, Alice Laudisio, Alberto Ballestrero, Stefano Scabini, Patrizio R. Odetti, Giuseppe F. Colloca, Fabio Monzani, Alessio Nencioni, Raffaele Antonelli Incalzi, Fiammetta Monacelli
Summary: Optimizing the approach to older adults with cancer is a priority due to the increasing frequency of new cancer diagnoses in this population. The comprehensive geriatric assessment (CGA) is crucial for defining prognosis, exploring the complexity of frail older individuals, and designing personalized interventions. The adoption of a standardized CGA model by oncology centers can lead to improved therapeutic choices and clinical outcomes by facilitating comparisons, promoting multidimensional patient assessments, and integrating geriatricians into oncology care teams.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Oncology
Josephine M. N. Lopes Cardozo, Sherylene E. Veira, Laila Ait Hassou, Aime Lambert Uwimana, Ivana Bozovic-Spasojevic, Jan Bogaerts, Fatima Cardoso, Marjanka K. Schmidt, Emiel J. T. Rutgers, Coralie Poncet, Caroline A. Drukker
Summary: This study assessed the agreement among breast cancer specialists on risk assessment and chemotherapy recommendation and found that there is variability in risk assessment among specialists. The 70-gene signature had an impact on risk assessment, resulting in a decrease in the number of patients assessed as high risk and a decrease in chemotherapy recommendations.
Article
Oncology
Peter van Dam, Mariano Tomatis, Antonio Ponti, Lorenza Marotti, Cynthia Aristei, Laura Biganzoli, Maria J. Cardoso, Kwok L. Cheung, Giuseppe Curigliano, Jakob De Vries, Donatella Santini, Francesco Sardanelli, Isabel Teresa Rubio
Summary: The study found that the quality of breast cancer care was well maintained in EUSOMA breast centers during the first wave of the COVID-19 pandemic, despite a decrease in the total number of new cases and a slightly higher tumor and lymph node stage at presentation.
EUROPEAN JOURNAL OF CANCER
(2022)
Editorial Material
Oncology
Takahiko Kawate, Atsushi Yoshida, Sadatoshi Sugae, Souta Asaga, Hiroshi Kaise, Shigehira Saji, Chikako Yamauchi, Yasuo Miyoshi, Hideko Yamauchi, Takashi Ishikawa
Summary: The COVID-19 pandemic has had a major impact on Japan, leading medical institutions to take measures to minimize infection risks. Cancer treatment remains a priority, even during the epidemic, due to concerns about decreasing curability.
Article
Radiology, Nuclear Medicine & Medical Imaging
Debra L. Monticciolo, Mary S. Newell, Linda Moy, Cindy S. Lee, Stamatia V. Destounis
Summary: Early detection is crucial in reducing breast cancer deaths, and higher-risk individuals should consider breast MRI for screening. Carriers of mutations can delay mammographic screening if annual screening breast MRI is performed. Individuals diagnosed with breast cancer before age 50 or with dense breasts should undergo annual supplemental breast MRI.
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2023)
Article
Urology & Nephrology
Rebecca K. Delaney, Brittany L. Sisco-Taylor, Xuechen Wang, Karen Scherr, Peter A. Ubel, Benjamin Haaland, Valerie C. Kahn, Daniel Hamstra, John T. Wei, Farrah Madanay, J. Kelly Davis, Taylor U. Greeno, Angela Fagerlin
Summary: The study aimed to examine the treatment recommendation patterns among urologists and radiation oncologists, concordance or discordance between physician recommendations, and the association between physician recommendations and the treatment that patients received. The findings revealed significant differences in treatment recommendations between urologists and radiation oncologists for patients with clinically localized prostate cancer, with each specialty favoring treatment aligned with their expertise.
Article
Oncology
Rene A. da Costa Vieira, Wesley P. Andrade, Sabas C. Vieira, Mauricio Romano, Gustavo Iglesias, Alexandre F. Oliveira
Summary: This article reviews the surgical aspects associated with locally advanced breast carcinoma, including indications, different surgeries, and associated complications. It also discusses special conditions and provides recommendations based on the literature.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Nicolo Matteo Luca Battisti, Nienke De Glas, Enrique Soto-Perez-de-Celis, Gabor Liposits, Michael Bringuier, Christine Walko, Stuart M. Lichtman, Matti Aapro, Kwok-Leung Cheung, Laura Biganzoli, Alistair Ring, Johanneke Portielje, Hans Wildiers, Etienne Brain
Summary: This study summarizes the evidence on efficacy, safety, and quality-of-life impacts of chemotherapy and the use and impact of gene expression profiling (GEP) in older patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer (EBC). The results show that chemotherapy survival benefits in older patients are unclear and GEP is less used. The prognostic role of GEP is established, but its predictive role remains unknown.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Nusrat Jahan, Elizabeth J. Cathcart-Rake, Kathryn J. Ruddy
Summary: The Oncology Grand Rounds series aims to help clinicians apply research findings to their own clinical practice by providing solutions to diagnostic and management challenges in the context of patient cases, as well as reviewing relevant literature.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Ginah Nightingale, Nicolo Matteo Luca Battisti, Kah Poh Loh, Martine Puts, Cindy Kenis, Annette Goldberg, Kristen R. Haase, Jessica Krok-Schoen, Gabor Liposits, Schroder Sattar, Petra Stolz-Baskett, Mackenzi Pergolotti
Summary: This article discusses the functional status of older cancer patients, including its impact on predicting chemotherapy toxicity and survival time, as well as the roles of individual members of an interprofessional team in addressing functional impairment, emphasizing the importance of preserving function.
JOURNAL OF GERIATRIC ONCOLOGY
(2021)
Article
Biochemical Research Methods
Dario Romagnoli, Agostina Nardone, Francesca Galardi, Marta Paoli, Francesca De Luca, Chiara Biagioni, Gian Marco Franceschini, Marta Pestrin, Giuseppina Sanna, Erica Moretti, Francesca Demichelis, Ilenia Migliaccio, Laura Biganzoli, Luca Malorni, Matteo Benelli
Summary: DNA-methylation alterations are common in cancer and can be used as ideal markers for tumor quantification and classification. The computational framework MIMESIS utilizes minimal DNA-methylation signatures to accurately estimate tumor content and classify tumor type and molecular subtype in tissue and cell-free DNA samples. The study demonstrates the potential of MIMESIS in developing cost-effective and scalable DNA-methylation assays for precision oncology in clinical practice.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Immunology
Tammie Choi, Bryan Chan, Lisa Grech, Alastair Kwok, Kate Webber, Jennifer Wong, Mike Nguyen, Nathan Bain, Daphne Day, Amelia McCartney, Ruby Hamer, Eva Segelov
Summary: This study investigates the factors influencing COVID-19 vaccine uptake among individuals with chronic illnesses in Australia. The qualitative analysis reveals that individuals with chronic illnesses have concerns about the vaccine's impact on their diseases and are uncertain about its benefits. It emphasizes the need for clinicians to address individual concerns and optimize vaccine uptake in this population.
Article
Public, Environmental & Occupational Health
Calogero Casa, Loredana Dinapoli, Elisa Marconi, Silvia Chiesa, Patrizia Cornacchione, Francesco Beghella Bartoli, Serena Bracci, Alessandra Salvati, Sara Scalise, Giuseppe Ferdinando Colloca, Daniela Pia Rosaria Chieffo, Maria Antonietta Gambacorta, Vincenzo Valentini, Luca Tagliaferri
Summary: Cancer diagnoses can lead to traumatic stress, changes in daily life, and challenges in treatment for patients. There is a growing demand for interventions to support emotional wellbeing, and oncology services are seeking to provide value-based healthcare while considering resource investment. This paper presents the Gemelli Advanced Radiation Therapy (ART) experience in personalizing care for cancer patients, involving technology and art, and emphasizes patient experiences and satisfaction indicators.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Oncology
E. -A. Bonci, J. Correia Anacleto, M. -J. Cardoso
Summary: Simple breast conservation surgery (sBCS) has advanced to oncoplastic breast procedures (OBP) to improve psychosocial well-being and cosmetic outcome. Despite the increase in OBP use, the choice between sBCS and OBP is difficult. Research on their safety, efficacy, and patient-reported outcomes is lacking.
Review
Sport Sciences
Ines Ramos Correia, Vasco Cardoso, Catarina Cargaleiro, Joao P. Magalhaes, Megan Hetherington-Rauth, Gil B. Rosa, Carla Malveiro, Leonor Vasconcelos de Matos, Maria Joao Cardoso, Luis B. Sardinha
Summary: This systematic review and meta-analysis aimed to investigate the effects of home-based exercise on physical fitness in cancer patients undergoing active treatment. The results showed that regular home-based exercise programs are effective in improving the 6-minute walk test for cancer patients undergoing active treatment, but no significant effects were found for muscle strength and body composition.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2023)
Article
Oncology
Katie Riches, Kwok-Leung Cheung, Vaughan Keeley
Summary: This paper explores the validity and reliability of measures to diagnose breast lymphedema, including ultrasound and tissue dielectric constant. The study found that breast lymphedema is associated with patient characteristics and breast cancer treatments.
Correction
Health Care Sciences & Services
Jelena Maksimenko, Pedro Pereira Rodrigues, Miki Nakazawa-Miklasevica, David Pinto, Edvins Miklasevics, Genadijs Trofimovics, Janis Gardovskis, Fatima Cardoso, Maria Joao Cardoso
JMIR FORMATIVE RESEARCH
(2023)
Article
Oncology
Ratul Quddus, Jessica Banks, Jenna L. Morgan, Charlene Martin, Malcolm W. R. Reed, Stephen Walters, Kwok Leung Cheung, Annaliza Todd, Riccardo Audisio, Tracy Green, Deirdre Revell, Jacqui Gath, Kieran Horgan, Chris Holcombe, Rishi Parmeshwar, Alastair Thompson, L. Wyld
Article
Oncology
Fatima Cardoso, Amelia McCartney, Antonio Ponti, Lorenza Marotti, Conny Vrieling, Alexandru Eniu, Berta Sousa, Carla Ripamonti, Luzia Travado, Sabine Spitz, Eva Jolly, Giuseppe Curigliano, Frederique Penault-Llorca, Frederic Lecouvet, Isabel T. Rubio, Laura Biganzoli
Summary: The European Society of Breast Cancer Specialists and the Advanced Breast Cancer Global Alliance have developed the first set of quality indicators for metastatic breast cancer (MBC) with the aim of ensuring high-quality care and adherence to guidelines in breast cancer centers.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Sport Sciences
Carla Malveiro, Ines R. Correia, Catarina Cargaleiro, Joao P. Magalhaes, Leonor Vasconcelos de Matos, Sofia Hilario, Luis B. Sardinha, Maria Joao Cardoso
Summary: This systematic review analyzed the effects of different exercise protocols on physical fitness, quality of life, cancer-related fatigue, and sleep quality in patients with different types of cancer undergoing neoadjuvant treatment. The review found that exercise interventions appeared to improve cardiorespiratory fitness, muscle strength, body composition, and overall quality of life.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2023)
Article
Engineering, Biomedical
Rafaela Timoteo, David Pinto, Marta Martinho, Pedro Gouveia, Daniel Simoes Lopes, Carlos Mavioso, Maria Joao Cardoso
Summary: Augmented reality (AR) can be beneficial for deep inferior epigastric artery perforator (DIEAP) flap reconstruction surgeries in terms of surgery planning and outcomes improvement. However, the anchorage of three-dimensional (3D) models to the patient's body during surgery does not consider skin deformation, leading to mismatch between the models and the patient. This study compares the 3D deformation registration from computed tomography angiography (CTA) position to surgical position and estimates the patient's skin deformation. The results show that there are cases of significant deformation, indicating the need for accurate 3D models using CTA data and considering projection errors when using AR technology.
MEDICAL ENGINEERING & PHYSICS
(2023)
Article
Multidisciplinary Sciences
Orit Kaidar-Person, Marilia Antunes, Jaime D. Cardoso, Oriana Ciani, Helena Cruz, Rosa Di Micco, Oreste Gentilini, Tiago Goncalves, Pedro Gouveia, Jorg Heil, Pawel Kabata, Daniela Lopes, Marta Martinho, Henrique P. Martins, Carlos Mavioso, Martin Mika, Helena Montenegro, Helder Oliveira, Andre Pfob, Nicole Rotmensz, Timo Schinkothe, Giovani Silva, Rosana Tarricone, Maria-Joao Cardoso, CINDERELLA Consortium
Summary: The CINDERELLA trial aims to evaluate the impact of an artificial-intelligence cloud-based platform on patient education prior to therapy for breast cancer. The platform will provide patients with a visual representation of their potential aesthetic outcomes and an objective evaluation. The goal is to improve patient satisfaction, enhance psychosocial well-being, and reduce the need for additional surgeries.
Article
Health Care Sciences & Services
Calogero Casa, Barbara Corvari, Francesco Cellini, Patrizia Cornacchione, Andrea D'Aviero, Sara Reina, Silvia Di Franco, Alessandra Salvati, Giuseppe Ferdinando Colloca, Alfredo Cesario, Stefano Patarnello, Mario Balducci, Alessio Giuseppe Morganti, Vincenzo Valentini, Maria Antonietta Gambacorta, Luca Tagliaferri
Summary: During the COVID-19 pandemic, the Radiation Oncology Department in Italy implemented an eHealth platform for televisit/monitoring/consultation to reduce patient exposure to the virus. Data collected from patients who underwent televisit/teleconsultation showed that the eHealth system was useful and user-friendly. Further research is needed to support widespread adoption.
Review
Medicine, General & Internal
Orit Kaidar-Person, Andre Pfob, Oreste Davide Gentilini, Bettina Borisch, Ana Bosch, Maria Joao Cardoso, Giuseppe Curigliano, Jana De Boniface, Carsten Denkert, Nik Hauser, Joerg Heil, Michael Knauer, Thorsten Kuehn, Han-Byoel Lee, Sibylle Loibl, Meinrad Mannhart, Icro Meattini, Giacomo Montagna, Katja Pinker, Fiorita Poulakaki, Isabel T. Rubio, Patrizia Sager, Petra Steyerova, Christoph Tausch, Trine Tramm, Marie-Jeanne Vrancken Peeters, Lynda Wyld, Jong Han Yu, Walter Paul Weber, Philip Poortmans, Peter Dubsky
Summary: Clinical axillary lymph node management in early breast cancer has evolved to involve the entire multidisciplinary team. The Lucerne Toolbox, a multidisciplinary consortium, addresses the challenges in clinical axillary lymph node management, proposing targeted imaging and standardized pathology as prerequisites to planning therapy, and the replacement of axillary lymph node dissection with sentinel lymph node biopsy in most scenarios. Positive patient outcomes should be driven by both low recurrence risks and low rates of lymphoedema.