Quantitative assessment of inflammatory infiltrates in kidney transplant biopsies using multiplex tyramide signal amplification and deep learning

CD68 + macrophages as crucial components of the foreign body reaction demonstrate an unconventional pattern of functional markers quantified by analysis with double fluorescence staining

(2020) Uwe Klinge et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Macrophages in Organ Transplantation

(2020) Farideh Ordikhani et al.   Frontiers in Immunology

Deep Learning–Based Histopathologic Assessment of Kidney Tissue

(2019) Meyke Hermsen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Computational Segmentation and Classification of Diabetic Glomerulosclerosis

(2019) Brandon Ginley et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

In situ multiplex immunofluorescence analysis of the inflammatory burden in kidney allograft rejection: A new tool to characterize the alloimmune response

(2019) Julien Calvani et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Learning to detect lymphocytes in immunohistochemistry with deep learning

(2019) Zaneta Swiderska-Chadaj et al.   MEDICAL IMAGE ANALYSIS

Scoring of tumor-infiltrating lymphocytes: From visual estimation to machine learning

(2018) F. Klauschen et al.   SEMINARS IN CANCER BIOLOGY

Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer

(2017) Babak Ehteshami Bejnordi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Eight-Color Multiplex Immunohistochemistry for Simultaneous Detection of Multiple Immune Checkpoint Molecules within the Tumor Microenvironment

(2017) Mark A. J. Gorris et al.   JOURNAL OF IMMUNOLOGY

Macrophage density in early surveillance biopsies predicts future renal transplant function

(2017) Jan Hinrich Bräsen et al.   KIDNEY INTERNATIONAL

A survey on deep learning in medical image analysis

(2017) Geert Litjens et al.   MEDICAL IMAGE ANALYSIS

Image analysis and machine learning in digital pathology: Challenges and opportunities

(2016) Anant Madabhushi et al.   MEDICAL IMAGE ANALYSIS

Infiltration of Macrophages Correlates with Severity of Allograft Rejection and Outcome in Human Kidney Transplantation

(2016) Tobias Bergler et al.   PLoS One

The Role of Macrophages in the Development of Human Renal Allograft Fibrosis in the First Year After Transplantation

(2014) D. Toki et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Delayed kidney graft function: from mechanism to translation

(2014) Bernd Schröppel et al.   KIDNEY INTERNATIONAL

Multiplexed immunohistochemistry, imaging, and quantitation: A review, with an assessment of Tyramide signal amplification, multispectral imaging and multiplex analysis

(2014) Edward C. Stack et al.   METHODS

Alternatively activated macrophages in the pathogenesis of chronic kidney allograft injury

(2014) Yohei Ikezumi et al.   PEDIATRIC NEPHROLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Delayed Graft Function in the Kidney Transplant

(2011) A. Siedlecki et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis

(2011) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

T helper 1, 2 and 17 cell subsets in renal transplant patients with delayed graft function

(2010) Antonia Loverre et al.   TRANSPLANT INTERNATIONAL

Scoring Total Inflammation Is Superior to the Current Banff Inflammation Score in Predicting Outcome and the Degree of Molecular Disturbance in Renal Allografts

(2009) M. Mengel et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis

(2008) S. G. Yarlagadda et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION