Journal
JOURNAL OF TRANSLATIONAL MEDICINE
Volume 19, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12967-021-02861-y
Keywords
Exosomes; MiRNAs; MiRs; Inter-cellular communication; GBMAx
Categories
Funding
- National Natural Science Foundation of China [81870939, 81571147, 14FTF19970029]
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This review discusses the potential functional link between EV-derived microRNAs and GBMAx, proposing that EV-derived microRNAs may serve as a novel regulatory system for GBMAx and a potential therapeutic target for modifying GBMAx in clinical therapy.
The gut-brain-microbiota axis (GBMAx) coordinates bidirectional communication between the gut and brain, and is increasingly recognized as playing a central role in physiology and disease. MicroRNAs are important intracellular components secreted by extracellular vesicles (EVs), which act as vital mediators of intercellular and interspecies communication. This review will present current advances in EV-derived microRNAs and their potential functional link with GBMAx. We propose that EV-derived microRNAs comprise a novel regulatory system for GBMAx, and a potential novel therapeutic target for modifying GBMAx in clinical therapy.
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