Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 143, Issue 15, Pages 5685-5690Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.1c02772
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Funding
- National Natural Science Foundation of China [21801220, 21672183, 22071139]
- Natural Science Foundation of Jiangsu Province [BK20180892]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Top-notch Academic Programs Project of Jiangsu Higher Education Institutions
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The first highly enantioselective catalytic synthesis of P-stereogenic secondary phosphine-boranes was achieved using a newly developed unsymmetric bisphosphine pincer-nickel complex. Various P-stereogenic secondary phosphine-boranes were obtained in good yields with high enantioselectivity and diastereoselectivity. Subsequent alkylation upon P-C bond formation provided a practical way to access P-chiral compounds with diverse functional groups.
The first highly enantioselective catalytic synthesis of P-stereogenic secondary phosphine-boranes was realized by the asymmetric addition of primary phosphine to electron-deficient alkenes with a newly developed unsymmetric bisphosphine (PCP') pincer-nickel complex. Various P-stereogenic secondary phosphine-boranes were obtained in 57-92% yields with up to 99% ee and >20:1 dr. The follow-up alkylation upon P-C bond formation with alkyl halides provided a practical way to access P-chiral compounds with diverse functional groups.
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