Journal
EUROPEAN JOURNAL OF INFLAMMATION
Volume 14, Issue 3, Pages 190-195Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1721727X16675628
Keywords
C-reactive protein; garlic; lipids; peripheral blood mononuclear cells (PBMC); tumor necrosis factor- (TNF-)
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Funding
- National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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This study was designed to investigate whether garlic tablets possess anti-inflammatory and lipid-lowering effects in healthy adults. Twelve healthy adults participated in a randomized, cross-over design with a three-week treatment and a two-week washout period. Participants received either garlic powder tablets twice daily or two placebo tablets/day for three weeks. Plasma and peripheral blood mononuclear cells (PBMC) were isolated from fasting blood samples at baseline and after each three-week treatment with garlic or placebo. PBMC were cultured, stimulated with lipopolysaccharide (LPS), and changes in cell culture supernatants tumor necrosis factor- (TNF-) levels were determined. In addition, changes in plasma high-sensitivity C-reactive protein (hs-CRP), as well as plasma levels of lipids were determined. After three weeks of supplementation, LPS-stimulated TNF- release in cell culture supernatant was lower after garlic than placebo (P <0.05) whereas no significant changes were observed in unstimulated TNF- release or plasma TNF-. There were no significant differences in plasma hs-CRP, cholesterol, triglyceride, LDL cholesterol, and HDL cholesterol levels between garlic and placebo. In healthy individuals, garlic supplementation did not change plasma levels of TNF- and hs-CRP while it caused lower TNF- release into cell culture supernatant after stimulation by LPS.
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