ROQUIN signalling pathways in innate and adaptive immunity

MicroRNA signatures differentiate Crohn’s disease from ulcerative colitis

(2015) Jeremy S Schaefer et al.   BMC IMMUNOLOGY

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

(2015) Takashi Mino et al.   CELL

Distinct inhibitory effects on mTOR signaling by ethanol and INK128 in diffuse large B-cell lymphoma

(2015) Krystyna Mazan-Mamczarz et al.   Cell Communication and Signaling

Calcineurin inhibitors dampen humoral immunity by acting directly on naive B cells

(2015) R. De Bruyne et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Posttranscriptional T cell gene regulation to limit Tfh cells and autoimmunity

(2015) Simon H Jiang et al.   CURRENT OPINION IN IMMUNOLOGY

OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response

(2015) Clément Jacquemin et al.   IMMUNITY

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

(2015) John P. Ray et al.   IMMUNITY

Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis

(2015) Monika Srivastava et al.   Nature Communications

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway

(2015) Yasuhiro Murakawa et al.   Nature Communications

MicroRNA-146a regulates ICOS–ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres

(2015) Alvin Pratama et al.   Nature Communications

New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins

(2015) Qi Zhang et al.   Scientific Reports

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

(2015) Roybel R Ramiscal et al.   eLife

Over-expression of Roquin aggravates T cell mediated hepatitis in transgenic mice using T cell specific promoter

(2014) Young Rae Ji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A role for IL-10 in the transcriptional regulation of Roquin-1

(2014) Jeremy S. Schaefer et al.   GENE

Posttranscriptional Modulation of Cytokine Production in T Cells for the Regulation of Excessive Inflammation by TFL

(2014) K. Minagawa et al.   JOURNAL OF IMMUNOLOGY

Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4+ CD4-CD8- Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus

(2014) H. Kato et al.   JOURNAL OF IMMUNOLOGY

Metformin Attenuates Experimental Autoimmune Arthritis through Reciprocal Regulation of Th17/Treg Balance and Osteoclastogenesis

(2014) Hye-Jin Son et al.   MEDIATORS OF INFLAMMATION

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation

(2014) Katharina M Jeltsch et al.   NATURE IMMUNOLOGY

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation

(2014) Andreas Schlundt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA

(2014) Dazhi Tan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Roquin-2 Promotes Ubiquitin-Mediated Degradation of ASK1 to Regulate Stress Responses

(2014) T. Maruyama et al.   Science Signaling

Hematopoietic not systemic impairment of Roquin expression accounts for intestinal inflammation in Roquin-deficient mice

(2014) Dina Montufar-Solis et al.   Scientific Reports

Interleukin-21 Promotes Germinal Center Reaction by Skewing the Follicular Regulatory T Cell to Follicular Helper T Cell Balance in Autoimmune BXD2 Mice

(2014) Yanna Ding et al.   Arthritis & Rheumatology

mRNA degradation by the endoribonuclease Regnase-1/ZC3H12a/MCPIP-1

(2013) Takuya Uehata et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing

(2013) Vivek Anantharaman et al.   Biology Direct

HTLV-1 Tax oncoprotein stimulates ROS production and apoptosis in T cells by interacting with USP10

(2013) M. Takahashi et al.   BLOOD

Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs

(2013) Kathrin Leppek et al.   CELL

Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells

(2013) Kathrin Thedieck et al.   CELL

Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling

(2013) Frank Wippich et al.   CELL

Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cells

(2013) Youn Soo Choi et al.   CURRENT OPINION IN IMMUNOLOGY

Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator mRNAs and Control Follicular Helper T Cell Differentiation

(2013) Katharina U. Vogel et al.   IMMUNITY

Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation

(2013) Alvin Pratama et al.   IMMUNITY

T-cell subsets in the germinal center

(2013) Roybel R. Ramiscal et al.   IMMUNOLOGICAL REVIEWS

Germinal center-independent, IgM-mediated autoimmunity in sanroque mice lacking Obf1

(2013) Stephane Chevrier et al.   IMMUNOLOGY AND CELL BIOLOGY

Small Intestine Inflammation in Roquin-Mutant and Roquin-Deficient Mice

(2013) Jeremy S. Schaefer et al.   PLoS One

Interferon-γ Excess Leads to Pathogenic Accumulation of Follicular Helper T Cells and Germinal Centers

(2012) Sau K. Lee et al.   IMMUNITY

LKB1 and AMPK: central regulators of lymphocyte metabolism and function

(2012) Julianna Blagih et al.   IMMUNOLOGICAL REVIEWS

Enforced Expression of Roquin Protein in T Cells Exacerbates the Incidence and Severity of Experimental Arthritis

(2012) Young Rae Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-146acontrols the resolution of T cell responses in mice

(2012) Lili Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Breakdown in Repression of IFN-  mRNA Leads to Accumulation of Self-Reactive Effector CD8+ T Cells

(2012) P.-P. Chang et al.   JOURNAL OF IMMUNOLOGY

ICOS-Dependent Homeostasis and Function of Foxp3+ Regulatory T Cells in Islets of Nonobese Diabetic Mice

(2012) M. Kornete et al.   JOURNAL OF IMMUNOLOGY

ICOS Mediates the Generation and Function of CD4+CD25+Foxp3+ Regulatory T Cells Conveying Respiratory Tolerance

(2012) M. Busse et al.   JOURNAL OF IMMUNOLOGY

Translation suppression promotes stress granule formation and cell survival in response to cold shock

(2012) Sarah Hofmann et al.   MOLECULAR BIOLOGY OF THE CELL

Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation

(2012) N. Bollig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T cells and Foxp3

(2011) Alexander Y. Rudensky   IMMUNOLOGICAL REVIEWS

Histone Deacetylase 9 Deficiency Protects against Effector T Cell-mediated Systemic Autoimmunity

(2011) Kailin Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monocyte Chemotactic Protein-induced Protein 1 (MCPIP1) Suppresses Stress Granule Formation and Determines Apoptosis under Stress

(2011) Dongfei Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Roquin induces early death and immune deregulation but not autoimmunity

(2011) Arianna Bertossi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

miR-146ais a significant brake on autoimmunity, myeloproliferation, and cancer in mice

(2011) Mark P. Boldin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathogen-Induced Inflammatory Environment Controls Effector and Memory CD8 + T Cell Differentiation

(2011) Joshua J. Obar et al.   JOURNAL OF IMMUNOLOGY

The Liver Kinase B1 Is a Central Regulator of T Cell Development, Activation, and Metabolism

(2011) Nancie J. MacIver et al.   JOURNAL OF IMMUNOLOGY

The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs

(2010) Vicki Athanasopoulos et al.   FEBS Journal

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression

(2010) Elke Glasmacher et al.   NATURE IMMUNOLOGY

The roles of TTP and BRF proteins in regulated mRNA decay

(2010) Sandhya Sanduja et al.   Wiley Interdisciplinary Reviews-RNA

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

(2009) R. J. Shaw   Acta Physiologica

Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity

(2009) Narender Nath et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Translational Mini-Review Series on Th17 Cells: Function and regulation of human T helper 17 cells in health and disease

(2009) S. Q. Crome et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Roquin Differentiates the Specialized Functions of Duplicated T Cell Costimulatory Receptor Genes Cd28 and Icos

(2009) Michelle A. Linterman et al.   IMMUNITY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Follicular helper T cells are required for systemic autoimmunity

(2009) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Generation of T Follicular Helper Cells Is Mediated by Interleukin-21 but Independent of T Helper 1, 2, or 17 Cell Lineages

(2008) Roza I. Nurieva et al.   IMMUNITY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Multifunctional deadenylase complexes diversify mRNA control

(2008) Aaron C. Goldstrohm et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY