Article
Engineering, Environmental
Chen Wu, Qi Wang, Hao Chen, Mengyan Li
Summary: A rapid analytical method combining nano-electrospray ionization and high-resolution mass spectrometry (Nano-ESI-HRMS) was developed for the detection of PFASs in water. AFFFs and wastewater were found to be the main sources of ultrashort-chain PFASs.
Article
Biochemistry & Molecular Biology
Jonghwa Lee, Kyeonga Kim, Jemin Son, Hyeseon Lee, Jin Han Song, Taek Lee, Heungbae Jeon, Hyun Soo Kim, Si Jae Park, Hah Young Yoo, Chulhwan Park
Summary: In this study, naringin oleate was synthesized through enzymatic esterification with optimized reaction conditions, resulting in a high conversion rate. This study presents an efficient method for synthesis that ensures high conversion within a shorter reaction time compared to previous methods.
Article
Plant Sciences
Vera A. Kostikova, Alexander A. Chernonosov, Alexander A. Kuznetsov, Natalia Petrova, Denis A. Krivenko, Olga A. Chernysheva, Wei Wang, Andrey S. Erst
Summary: Eranthis longistipitata leaves contain a variety of flavonoid compounds, mainly flavonols. The diversity of these compounds may be influenced by external ecological and geographic factors as well as adaptive mechanisms.
Article
Biochemistry & Molecular Biology
Yuanyue Zhang, Shengbao Cai, Shuang Ma, Shuai Zhao, Junjie Yi, Linyan Zhou
Summary: This study aimed to investigate the phenolic profiles, antioxidant activities, and alpha-glycosidase inhibitory activities of water caltrop husk. The results showed that tannins were the main constituents, and the free phenolic fraction exhibited the strongest inhibition towards alpha-glycosidase and had good antioxidant activities.
Article
Chemistry, Applied
Hasya Nazli Gok, Simon Vlad Luca, Saadet Tugrul Ay, Lukasz Komsta, Ramin Ekhteiari Salmas, Ilkay Erdogan Orhan, Krystyna Skalicka-Wozniak
Summary: The ethanol extracts of five Origanum species showed significant cholinesterase inhibition and antioxidant effects, with the phytochemical composition of 60 extracts analyzed. The study also identified a correlation between certain compounds and bioactivity. Additionally, molecular docking data suggested that caffeoylarbutin had the lowest binding energy against both AChE and BChE.
Article
Biochemistry & Molecular Biology
Vera A. Kostikova, Natalia V. Petrova, Tatiana M. Shaldaeva, Vladimir V. Koval, Alexander A. Chernonosov
Summary: Metabolite profiling of Spiraea hypericifolia collected in Siberia was conducted using liquid chromatography combined with high-resolution mass spectrometry. Multiple compounds were identified in the extract, including amino acids, sugars, phenylpropanoids, fatty acids, triterpenoids, flavonoids, and others. Quantitative analysis showed the predominance of phenolcarboxylic acids and flavonoids, while qualitative analysis revealed the high structural diversity of flavonoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Luhong Wang, Lixue Chen, Yichen Yao, Hongyan Shen, Youjun Xu
Summary: The fragmentation mechanisms of prazoles and their related substances were investigated using positive mode ESI-TOF HRMS1 and HRMS2. Novel fragmentation rules and ions were discovered in the research. Heterolytic fragmentations occurred near the -S(O)(n)CH2- linker, resulting in the formation of [1,3]-H migration ion or [1,7]-H migration ion rearranging across the benzoimidazole ring. Smiles rearrangement ionizations frequently occurred, initiated by the attack of lone pair electrons from the pyridine ring. Some new and interesting fragment ions containing bivalent, tetravalent, or hexavalent sulfurs were reported for the first time.
Article
Biochemistry & Molecular Biology
Bo-Yang Hsu, Chen-Te Jen, Baskaran Stephen Inbaraj, Bing-Huei Chen
Summary: This study developed two methods for the analysis of ginsenosides in ginseng root residue and compared the results. The findings showed that both methods were able to effectively separate and detect ginsenosides in ginseng root residue. The study also demonstrated the quantitation limits and precision of these methods, and revealed the content range of nine ginsenosides in ginseng root residue.
Article
Endocrinology & Metabolism
Yue Gao, Jingjie Li, Shicheng Fan, Pan Chen, Min Huang, Huichang Bi
Summary: This study used lipidomic analysis to investigate the changes in lipid profiles in ovarian hyperstimulation syndrome (OHSS) patients and identified key lipids associated with the development of OHSS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Hidenori Matsukami, Shunji Hashimoto, Go Suzuki
Summary: Investigation into a novel flame retardant TDBP-TAZTO and its transformation products revealed challenges in their removal by current sewage treatment processes, raising concerns over environmental contamination and human health risks. The study findings are valuable for assessing and predicting the impact of these compounds on environmental pollution and human health risks, as well as for developing measures to control emissions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Applied
Ana Paula Terezan, Joao Gabriel M. Junqueira, Vinicius G. Wakui, Lucilia Kato, Cecilia Maria A. Oliveira, Carlos Henrique G. Martins, Mariana B. Santiago, Vanessa Gisele P. Severino
Summary: Araticum, a traditional herb in the Brazilian cerrado, is an edible and appreciable fruit. A study found that HPLC-ESI-Q-Orbitrap (R) is an efficient method for analyzing the complex mixture of annonaceous acetogenins, and two specific compounds were identified for the first time. Additionally, the crude leaf extract and acetogenin-rich fractions showed inhibitory effects against oral infection-related bacteria.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemical Research Methods
Augusto L. Santos, Marisi G. Soares, Livia S. de Medeiros, Marcelo J. P. Ferreira, Patricia Sartorelli
Summary: This study characterized the EtOAc phase from the methanolic extract of C. arborea leaves using UHPLC-DAD-HRMS/MS and molecular networking-based dereplication, identifying flavonoid-3-O-glycoside derivatives.
PHYTOCHEMICAL ANALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Hannes Meinert, Dong Yi, Bastian Zirpel, Eva Schuiten, Torsten Geissler, Egon Gross, Stephan Brueckner, Beate Hartmann, Carsten Roettger, Jakob P. Ley, Uwe T. Bornscheuer
Summary: The discovery of 66 novel bacterial CHIs reveals diversity in substrate specificity towards various hydroxylated and methoxylated chalcones. Mutagenesis of CHIera based on the binding models of these novel bacterial CHIs resulted in variants with significantly improved activity. Preparative scale conversion catalyzed by bacterial CHIs showed (S)-selectivity with up to 96% ee, providing an alternative biocatalytic route for the synthesis of (S)-flavanones in high yields.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Food Science & Technology
Shruti Sharma, Robin Joshi, Dinesh Kumar
Summary: The study investigated and compared the nutritional potential and chemical diversity of different parts of Polygonatum verticillatum, revealing that leaves contain the highest polyphenols and amino acids, while fruits exhibit the highest antioxidant activity. The findings suggest that all parts have similar nutritional potential and utilizing aerial parts instead of rhizomes could prevent overexploitation of the plant.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Plant Sciences
Saied A. Aboushanab, Vadim A. Shevyrin, Grigory P. Slesarev, Vsevolod V. Melekhin, Anna Shcheglova, Oleg G. Makeev, Elena G. Kovaleva, Ki Hyun Kim
Summary: Pediatric solid tumors pose a threat to children's health, and soy and kudzu root extracts have been found to have antioxidant and cytotoxic effects, making them potential alternatives for treating these tumors.
Article
Food Science & Technology
Camila da Costa Pinto, Edgar Aparecido Sanches, Maria Teresa Pedrosa Silva Clerici, Sueli Rodrigues, Fabiano Andre Narciso Fernandes, Sergio Michielon de Souza, Barbara Elisabeth Teixeira-Costa, Jaqueline de Araujo Bezerra, Carlos Victor Lamarao, Pedro Henrique Campelo
Summary: This study examined the effect of cold plasma excitation frequency on the physicochemical properties of unconventional starches, such as Goeppertia allouia. Different excitation frequencies were used to treat the starches, and the resulting changes in morphology and physicochemical properties were investigated. It was found that the excitation frequency can modulate the phase composition, crystallinity, hydration properties, and content of resistant starch in the starches.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Food Science & Technology
Lucia S. Boeira, Sandra Cad, Jaqueline A. Bezerra, Cesar T. Benavente, Maria Terezinha S. L. Neta, Rafael Donizete Dutra Sandes, Narendra Narain
Summary: This study aimed to transform the Amazonian native acai fruit into an attractive and functional product by macerating it in alcohol vinegar. The variables studied were the vinegar to acai proportion and maceration period. The vinegar obtained had similar color, antioxidant capacity, and total phenolic content to vinegars from fruits and red wine. A total of 60 volatile compounds were identified, and the most attractive product was obtained from a 1:1 vinegar to acai ratio and a 14-day maceration period. Practical Application: This study demonstrates the feasibility of producing an alcohol vinegar with attractive color and functional properties by adding acai, resulting in a wide range of chemical compounds from acai. Rating: 9/10.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Engineering, Chemical
Josias M. dos A. Cruz, Andrezza S. S. Ramos, Renilto F. F. Correa, Edgar A. A. Sanches, Pedro H. H. Campelo, Valdely F. F. Kinupp, Jaqueline de A. Bezerra
Summary: This study evaluated the influence of heat treatment and high-intensity ultrasound on the chemical profile of Amazon fig juices. The results showed that heat treatment significantly influenced antioxidant activity, carotenoid content, and total phenolic compounds. High-intensity ultrasound affected color luminosity but had no significant effect on chemical composition.
Review
Food Science & Technology
Zilanir Carvalho Pereira, Josias Martins dos Anjos Cruz, Renilto Frota Correa, Edgar Aparecido Sanches, Pedro Henrique Campelo, Jaqueline de Araujo Bezerra
Summary: This review focuses on the chemical composition, health benefits, and products derived from the pulps of Passiflora spp. over the last 5 years. Phenolic acids and polyphenols were among the major organic compounds found in the pulps of Passiflora spp. The fruits demonstrated antioxidant properties as well as inhibition of alpha-amylase and alpha-glucosidase enzymes. These findings indicate the potential use of Passiflora spp. in developing a variety of products, especially non-dairy beverages, to meet consumer demand for alternatives. Sensory analysis and in vivo tests are encouraged to further explore the development of pharmaceutical and food products with high value. Patents also show considerable interest in research and product development in various food technology areas, as well as biotechnology, pharmacy, and materials engineering.
FOOD RESEARCH INTERNATIONAL
(2023)
Review
Food Science & Technology
Jaqueline de Araujo Bezerra, Carlos Victor Lamarao, Edgar Aparecido Sanches, Sueli Rodrigues, Fabiano A. N. Fernandes, Gustavo Luis P. A. Ramos, Erick Almeida Esmerino, Adriano G. Cruz, Pedro H. Campelo
Summary: Thermal processes can damage the nutritional and sensory quality of foods, but non-thermal technologies, such as cold plasma, have potential applications in food processing. Cold plasma can be used for preserving and sanitizing food products, as well as a pre-treatment for drying, extraction, cooking, curing, and hydrogenation of foods. It can also improve the sensory and nutritional aspects of foods. However, challenges such as scaling up, optimizing effects on nutritional and sensory quality, and developing bigger or more powerful plasma systems still need to be addressed.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Plant Sciences
Edinilze S. C. Oliveira, Leonard D. R. Acho, Ruben Dario Morales-Gamba, Alessandro S. do Rosario, Jose Fernando M. Barcellos, Emerson S. Lima, Marcos B. Machado
Summary: The dry extract of Myrcia multiflora leaves has a hypoglycemic effect on diabetic mice and exerts nephro- and hepatoprotective effects. It has the potential to be an adjuvant for diabetes mellitus type 2, similar to acarbose.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Flavio Henrique Souza de Araujo, Claudio Rodrigo Nogueira, Virginia Demarchi Kappel Trichez, Zaira da Rosa Guterres, Luciano da Silva Pinto, Suzana Queiroz Velter, Guilherme Antonio Mantovani Ferreira, Marcos Batista Machado, Kidney de Oliveira Gomes Neves, Maria do Carmo Vieira, Claudia Andrea Lima Cardoso, Silvia Cristina Heredia-Vieira, Kelly Mari Pires de Oliveira, Raul Cremonize Piva, Silvia Aparecida Oesterreich
Summary: The infusion of Aristolochia triangularis leaves showed anti-hyperglycemic activity and contained lignoids, alkaloids, and glycosylated flavonoids with known antidiabetic effects. This supports the traditional use of this herbal drink in Brazilian traditional medicine for diabetes management.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Laila Yasmim dos Santos Silva, Andrezza da Silva Ramos, Debora Nogueira Cavalcante, Valdely Ferreira Kinupp, Joao Vitor da Silva Rodrigues, Bianca Muniz Lacerda Ventura, Tiago Antonio de Oliveira Mendes, Edgar Aparecido Sanches, Pedro Henrique Campelo, Jaqueline de Araujo Bezerra
Summary: The consumption of edible flowers, such as Hibiscus acetosella Welw. Ex Hiern, is beneficial for human health due to their rich bioactive compounds, high antioxidant activity, and absence of cytotoxicity. These flowers are particularly valuable for their high content of organic acids and phenolic compounds, including myricetin, quercetin derivatives, kaempferol, and anthocyanins. Therefore, they have great potential as nutraceuticals in the healthy food industry.
Article
Biotechnology & Applied Microbiology
Guilherme F. Picheth, Gabriela C. Cardoso, Michelle B. Collini, Joao O. C. Filizzola, Leonardo B. Colauto, Giovana G. Nunes, Cleverton L. Pirich, Thiago Alessandre da Silva, Flavia L. D. Pontes, Ingrid F. Zattoni, Edneia A. S. R. Cavalieri, Giseli Klassen
Summary: The study aimed to develop and analyze targeted nanoparticles for triple-negative breast cancer loaded with the demethylating agent decitabine. The polymers were synthesized using ring-opening polymerization and formulated into nanoparticles using the emulsion-evaporation method. Physicochemical analysis and in vitro experiments were conducted to characterize the nanoparticles using breast cancer cell lineages. The results showed that the targeted nanoparticles had a hydrodynamic diameter of 75 +/- 12 nm, zeta potential of -6.3 +/- 0.2 mV, spherical morphology, and exhibited greater in vitro accumulation in MDA-MB-231 cells compared to MCF7 and HB4A cells, as well as significant demethylating effects.
Review
Food Science & Technology
Andreza Cavalcante de Oliveira, Josiana Moreira Mar, Renilto Frota Correa, Edgar Aparecido Sanches, Pedro Henrique Campelo, Andrezza da Silva Ramos, Jaqueline de Araujo Bezerra
Summary: This comprehensive review aims to shed light on the principal volatile and non-volatile chemical components found in Pouteria fruits, which present notable antioxidant properties. It provides a broad perspective on the current trends in characterizing these compounds and their potential applications, as well as the associated health benefits. Additionally, the prospects and potential applications of Pouteria fruits in the food industry are explored herein.
FOOD RESEARCH INTERNATIONAL
(2023)
Review
Food Science & Technology
Heloisa de Fatima Mendes Justino, Israel Felipe dos Santos, Ruan Carlos Nascimento de Souza, Edgar Aparecido Sanches, Jaqueline de Araujo Bezerra, Carlos Victor Lamarao, Ana Clarissa dos Santos Pires, Pedro Henrique Campelo
Summary: The adoption of vegetarian diets is on the rise among people who want to improve their health and reduce their environmental impact. However, there is concern about obtaining sufficient protein with nutritional quality similar to animal-derived proteins in a vegetarian diet. Studies have shown that the application of ultrasound to plant proteins can effectively modify their structure and enhance their digestibility, solubility, and viscosity, leading to improved nutritional and technological properties.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ulana Cristina de Araujo Tavares, Juliana Maria Nascimento dos Santos, Savio Gorgonio Paes de Bulhoes, Lucas Gabriel de Medeiros da Silva, Veronica da Silva Oliveira, Emanuella de Aragao Tavares, Raimundo Fernandes de Araujo Jr, Valeria Costa da Silva, Gerlane Coelho Bernardo Guerra, Emerson Silva Lima, Valdir Florencio da Veiga Jr, Attilio Converti, Adley Antonini Neves de Lima
Summary: This study demonstrates that ABAME-containing chitosan films can effectively promote wound healing and alleviate inflammatory reactions.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemical Research Methods
Romario da S. Santana, Felipe de S. Mendes, Barbara J. Paula da Silva, Emerson S. Lima, Thiago P. Nascimento, Marcia N. Carneiro da Cunha, Ana Lucia F. Porto, Maria Francisca S. Teixeira, Rosany P. Carvalho, Waldireny R. Gomes
Summary: This study investigated the production of crude extracts from two species of edible mushrooms through submerged fermentation and evaluated their antioxidant, cytotoxic, and fibrinolytic activities. The results showed that the mushroom extracts had low cytotoxicity, good antioxidant activity, and the supplementation of malt broth favored the production of fibrinolytic proteases.
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
(2023)
Article
Agronomy
Angela Maria Comapa Barros, Ana Cristina da Silva Pinto, Fernanda Guilhon Simplicio, Francisco Celio Maia Chaves, Noam Gadelha da Silva, Kelson Mota Teixeira de Oliveira, Emersom Silva Lima, Antonia Maria Ramos Franco
Summary: This study evaluated the toxic potential of dillapiole n-butyl ether (DBE) against Leishmania species and its toxicity on human peripheral blood mononuclear cells (PBMCs). The results showed that DBE exhibited promising antileishmanial potential with low toxicity on human cells.
Article
Chemistry, Multidisciplinary
Rodrigo O. S. de Souza, Livia C. R. Hilgenberg, Ana C. S. Pinto, Renyer A. Costa, Fernanda G. Simplicio, Emerson S. Lima
Summary: This study synthesized a new flavonoid derivative, DCHA, and confirmed its structure through spectroscopic analysis. DCHA showed anti-inflammatory activity by inhibiting the activation of target enzymes. This is the first work to demonstrate the high anti-inflammatory potential of a flavonoid derivative with aminoguanidine.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Analytical
Bingbing Liu, Jie Cao, Lu Liu, Min Zeng, Hongli Yu, Hao Wu
Summary: This study investigated the effect of processing with Chebulae Fructus on the chemical composition of Euphorbia pekinensis (EP) and found that it could alter the composition and reduce toxicity, providing a scientific basis for optimizing processing technology and handling other ethnomedicines with toxic properties.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Renuka P. Rathnasekara, Abu M. Rustum
Summary: A simple and robust HPLC method was developed for simultaneous determination of four active pharmaceutical ingredients and their degradation products. The method successfully separated the peaks of interest and demonstrated stability-indicating capability by separating the degradation products in stressed samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Bryan Lee, Gita Kharal, Benjamin Sreenan, Claire Lin, Ruosheng Zeng, Colin A. Fox, Patricia Ellison, Robert O. Ryan, Paul J. Brett, David Aucoin, Xiaoshan Zhu
Summary: In this study, a new type of Mn-doped nanocrystals was developed for detecting a biomarker of a fatal disease. The sensitivity of the detection was enhanced by surface treatment and time-resolved reading, achieving a detection limit comparable to enzyme-based immunoassay.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xiaoling Liu, Ting Yang, Lu Chen, Lili Lan, Guoxiang Sun, Ping Guo
Summary: In this study, the quality of Yiqing tablet was comprehensively evaluated using multi-component quantification, multi-dimensional fingerprint construction, and antioxidant activity analysis. The results showed that the sample had 25 components with antioxidant activity according to the HPLC fingerprint and most bands of FTIR also showed antioxidant activity. Based on the evaluation results of HPLC and FTIR fingerprint, all samples were classified as first level, demonstrating the consistency of sample quality. This study provides a new idea for achieving comprehensive quality evaluation of traditional Chinese medicines.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Siqi Li, Hao Guo, Yan Gao, Wen Tian, Shan Wang, Chen Shen, Lili Xu, Hailong Liu, Jinliang Zhang, Yingwu Wang
Summary: Using competitive ELISA to detect free cytokines is limited in accurately determining their real state and quantity. In this study, a novel cytokine immunoassay was developed using Rosetta molecular docking prediction technique to establish a method that can detect the true concentration of free cytokines without disrupting the dynamic equilibrium.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Changqing Yu, Tiantian Xie, Haiyan Liu, Ligai Bai
Summary: A phenyl-hybrid monolithic adsorbent with porous structure and multiple functional groups was prepared. It was used for the online extraction and quantification of coumarins in mouse plasma, showing good removal ability and selectivity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Joao B. Pereira Jr, Vanessa S. Carvalho, William Q. Ferreira, Rennan G. O. Araujo, Sergio L. C. Ferreira
Summary: This work presents a simple, cost-effective, and environmentally friendly method for determining the content of multiple elements in medicinal herbs using ICP OES. The optimized experimental parameters result in low dissolved organic carbon content and residual acidity concentration. The accuracy of the method is confirmed through the analysis of certified reference materials, and its environmental friendliness is validated using the AGREE metric. Principal component analysis is used to classify the medicinal herbs based on their inorganic constituent concentrations.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Orwa Siddig, Chenxi Liu, Mohamed Abdulbagi, Min Song, Yu-ting Lu, Tai-jun Hang
Summary: In this study, a reliable LC-QTOF-MS method was developed to separate and characterize process-related substances and degradation products of Lurasidone hydrochloride. The results showed that Lurasidone hydrochloride exhibited instability under certain stress conditions, and several previously unidentified compounds were discovered. The study emphasizes the importance of monitoring and controlling related substances in the manufacturing processes to optimize the process and ensure quality control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Jiaxi Fang, Luping Wang, Di Zhang, Yan Liang, Shouxin Li, Jingkui Tian, Qiang He, Juan Jin, Wei Zhu
Summary: This study reports that a novel compound called CPS-A exhibits therapeutic effects on cisplatin-induced acute kidney injury (AKI) and explores its potential mechanisms through transcriptomics and metabolomics. CPS-A improves cell viability, reduces inflammatory markers, and attenuates cisplatin-induced kidney injury. The study also identifies potential targets related to amino acid metabolism.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ricardo Conde, Nadia Oliveira, Elisabete Morais, Ana Paula Amaral, Adriana Sousa, Goncalo Graca, Ignacio Verde
Summary: Decreased levels of tyrosine, glutamate, valine, leucine, and isoleucine are associated with worsening pathological cognitive decline. Decreased levels of isobutyrate, histidine, acetone, and unknown-1 metabolite are potential biomarkers with neuroprotective and antioxidant actions for cognitive decline.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
A. L. Santunione, F. Palazzoli, P. Verri, D. Vandelli, V. Castagnetti, C. Profeta, E. Silingardi
Summary: This study describes two fatal suicide cases involving four cardiovascular drugs, and presents the concentrations and distribution of these drugs in different post-mortem specimens. The study developed a fast, sensitive, and simple method for drug detection suitable for forensic purposes.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Meiyun Shi, Xinyue Zheng, Yuncheng Ge, Ning Zhang, Luyao Yu, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin
Summary: This study investigated the cellular uptake of low, medium and high molecular weight polyethylene glycol (PEG) in MCF-7 cells using UPLC-MS/MS and CID techniques. The results showed that PEG600, PEG2K, PEG4K and PEG10K exhibited low toxicity and had limited cellular entry at concentrations of 5-1200 μg/mL. Additionally, the environmental friendliness of the developed analytical methods was evaluated.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ruijin Geng, Mengjie Yu, Jinbiao Xu, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie
Summary: This study validated serum methionine as a potential biomarker for Kawasaki disease (KD), and found that its alteration is associated with the activation of DNMT1 in KD patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Eman Shawky, Rasha A. Nassra, Aliaa M. T. El-Alkamy, Shaimaa M. Sallam, Samah M. El Sohafy
Summary: This study employed network pharmacology-based analysis and reverse molecular docking to investigate the molecular targets and pathways associated with gynecological disorders and the potential therapeutic effects of fenugreek constituents. The results highlighted the potential of steroidal saponins, isoflavones, and flavones as active constituents of fenugreek with implications for lactation, reproductive processes, and estrogenic activity. Animal model study further supported the presence of these bioactive compounds and their effects on body weight, serum prolactin levels, serum estradiol levels, and ovarian histological structure.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xuelong Zhao, Ruixue Dai, Jing Wang, Liangliang Cao, Peidong Chen, Weifeng Yao, Fangfang Cheng, Beihua Bao, Li Zhang
Summary: This study identified the skin-permeable and skin-retainable components of Cayratia japonica ointment and found that flavonoids are the main active components that play a crucial role in the inflammatory and proliferative phases of wound healing.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
