Characterization of stress degradation products of nintedanib by UPLC, UHPLC-Q-TOF/MS/MS and NMR: Evidence of a degradation product with a structure alert for mutagenicity

QbD-mediated RP-UPLC method development invoking an FMEA-based risk assessment to estimate nintedanib degradation products and their pathways

(2020) Balaji Jayagopal et al.   Arabian Journal of Chemistry

The Degradation Chemistry of Prasugrel Hydrochloride: Part 1—Drug Substance

(2019) Steven W. Baertschi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Stability behaviour of antiretroviral drugs and their combinations. 10: LC-HRMS, LC-MSn, LC-NMR and NMR characterization of fosamprenavir degradation products and in silico determination of their ADMET properties

(2019) Dilip Kumar Singh et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Quality by Design as a risk-based strategy in pharmaceutical analysis: Development of a liquid chromatography-tandem mass spectrometry method for the determination of nintedanib and its impurities

(2019) Benedetta Pasquini et al.   JOURNAL OF CHROMATOGRAPHY A

Trends in mortality from idiopathic pulmonary fibrosis in the European Union: an observational study of the WHO mortality database from 2001–2013

(2018) Dominic C. Marshall et al.   EUROPEAN RESPIRATORY JOURNAL

Stability behaviour of antiretroviral drugs and their combinations. 8: Characterization and in-silico toxicity prediction of degradation products of efavirenz

(2018) Moolchand Kurmi et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Application of the UHPLC method for separation and characterization of major photolytic degradation products of trazodone by LC-MS and NMR

(2018) Mohit Thummar et al.   NEW JOURNAL OF CHEMISTRY

Stability behaviour of antiretroviral drugs and their combinations. 5: Characterization of novel degradation products of abacavir sulfate by mass and nuclear magnetic resonance spectrometry

(2017) Moolchand Kurmi et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Characterization of stress degradation products of amodiaquine dihydrochloride by liquid chromatography with high-resolution mass spectrometry and prediction of their properties by using ADMET Predictor™

(2017) Vivek Dhiman et al.   JOURNAL OF SEPARATION SCIENCE

Simultaneous determination of nintedanib and its metabolite by UPLC–MS/MS in rat plasma and its application to a pharmacokinetic study

(2016) Dan Lin et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Stability behaviour of antiretroviral drugs and their combinations. 4: Characterization of degradation products of tenofovir alafenamide fumarate and comparison of its degradation and stability behaviour with tenofovir disoproxil fumarate

(2016) Vijaya Madhyanapu Golla et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Fragmentation reactions using electrospray ionization mass spectrometry: an important tool for the structural elucidation and characterization of synthetic and natural products

(2016) Daniel P. Demarque et al.   NATURAL PRODUCT REPORTS

Characterization of Synthetic and Natural Product Pharmaceuticals by Functional Group Analysis using Electrospray Ionization-Ion Trap Mass Spectrometry: A Mini-Review

(2015) W. Franklin Smyth et al.   ANALYTICAL LETTERS

Structural characterization of alkaline and oxidative stressed degradation products of lurasidone using LC/ESI/QTOF/MS/MS

(2015) M.V.N. Kumar Talluri et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

AIBN-Catalyzed Oxidative Cleavage of gem-Disubstituted Alkenes with O2 as an Oxidant

(2014) Guang-Zu Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Characterization of a new degradation product of nifedipine formed on catalysis by atenolol: A typical case of alteration of degradation pathway of one drug by another

(2013) Tarun Handa et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Critical practical aspects in the application of liquid chromatography–mass spectrometric studies for the characterization of impurities and degradation products

(2013) Mallikarjun Narayanam et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Direct Evidence of 2-Cyano-2-Propoxy Radical Activity During AIBN-Based Oxidative Stress Testing in Acetonitrile–Water Solvent Systems

(2013) Michael A. Watkins et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Forced degradation studies to assess the stability of drugs and products

(2013) Saranjit Singh et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

A critical review on the use of modern sophisticated hyphenated tools in the characterization of impurities and degradation products

(2012) Saranjit Singh et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Influence of Microenvironment pH, Humidity, and Temperature on the Stability of Polymorphic and Amorphous Forms of Clopidogrel Bisulfate

(2010) Dhara K. Raijada et al.   AAPS PHARMSCITECH