Article
Critical Care Medicine
Regan E. Giesinger, Danielle R. Rios, Trassanee Chatmethakul, Adrianne R. Bischoff, Jeremy A. Sandgren, Alison Cunningham, Madeline Beauchene, Amy H. Stanford, Jonathan M. Klein, Patrick Ten Eyck, Patrick J. McNamara
Summary: This study evaluates the role of early hemodynamic screening in the risk of death or severe intraventricular hemorrhage in preterm infants. The findings show that screening significantly reduces the primary composite outcome of death or severe intraventricular hemorrhage, suggesting that early hemodynamic screening and tailored care may improve neonatal outcomes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Oncology
Joanne Delaney, Gabriela De Carvalho Nunes, Jessica Simoneau, Marc Beltempo, Isabelle Malhame, Catherine Goudie, Gabriel Altit
Summary: Premature infants exposed to hypertensive disorders of pregnancy (HDP) have lower platelet counts at different time points, a higher prevalence of platelet counts less than 150 x 10^9/L at one time point, and increased frequency of platelet transfusion. HDP is associated with a lower trend in platelet counts.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Pediatrics
Ira H. Gewolb, Babatunde T. Sobowale, Frank L. Vice, Abhijit Patwardhan, Nino Solomonia, Eric W. Reynolds
Summary: The study found that severe intraventricular hemorrhage (IVH) negatively impacts suck-suck and suck-swallow rhythms, and the independent effect of neurological injury suggests that quantitative analysis of feeding may reflect and predict neurological sequelae.
FRONTIERS IN PEDIATRICS
(2021)
Review
Obstetrics & Gynecology
Deep R. Sharma, Alex Agyemang, Praveen Ballabh
Summary: Intraventricular hemorrhage (IVH) primarily damages the periventricular white matter, but it also causes substantial injury to the cerebral gray matter. The injury mechanism involves oxidative stress, inflammation, and mass effect, leading to cognitive deficits and neurobehavioral disorders. Neuroimaging can predict neurodevelopmental outcomes. Therapies targeting neurogenesis, reducing inflammation and oxidative stress, and removing blood clots from the ventricles may enhance the outcomes of infants with IVH.
SEMINARS IN PERINATOLOGY
(2022)
Article
Pediatrics
Janessa B. Law, Thomas R. Wood, Semsa Gogcu, Bryan A. Comstock, Manjiri Dighe, Krystle Perez, Mihai Puia-Dumitrescu, Dennis E. Mayock, Patrick J. Heagerty, Sandra E. Juul
Summary: The study aimed to determine the incidence, timing, progression, and risk factors of intracranial hemorrhage (ICH) in extremely preterm infants, as well as its association with death or neurodevelopmental impairment (NDI) at 2 years of corrected age. Risk factors for ICH varied by timing of bleed, and bilateral or increasing grade of ICH were associated with adverse outcomes in infants born extremely preterm.
JOURNAL OF PEDIATRICS
(2021)
Article
Clinical Neurology
Koichiro Sumi, Takeshi Suma, Reona Yoshida, Ryuta Kajimoto, Masato Kobayashi, Takamichi Katsuhara, Koki Hirayama, Xiaoyan Tang, Naoki Otani, Atsuo Yoshino
Summary: Meningiomas are common benign intracranial tumors, but those arising from the ventricular system are rare and can result in spontaneous hemorrhage. A case study of a 28-year-old female with acute intracranial hemorrhage due to intraventricular meningioma highlights the importance of recognizing this rare event. Early surgical intervention is suggested for patients with lateral ventricular meningioma, even if the tumor is small or asymptomatic.
Review
Clinical Neurology
Eun-Kyung Park, Ja-Yoon Kim, Dong-Seok Kim, Kyu-Won Shim
Summary: Post-hemorrhagic hydrocephalus (PHH) in preterm infants is common and life-threatening, resulting in bad developmental outcomes. Ventriculoperitoneal (VP) shunt is used as the ultimate treatment for PHH. The most important prognostic factor for VP shunting is age, but low birth weight and low gestational age also contribute to worse prognosis. Early and aggressive intervention can effectively control intraventricular hemorrhage and intracranial pressures, reducing the risk of infection and brain damage. Allowing PHH infants to mature and gain weight before undergoing VP shunt is crucial to reduce shunt-related complications.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2023)
Article
Clinical Neurology
Sruthi Ramagiri, Shelei Pan, Dakota DeFreitas, Peter H. Yang, Dhvanii K. Raval, David F. Wozniak, Prabagaran Esakky, Jennifer M. Strahle
Summary: Posthemorrhagic hydrocephalus is a common complication of intraventricular hemorrhage in infants. This study develops an animal model of intraventricular hemorrhage and demonstrates that administration of the iron chelator deferoxamine at the time of hemorrhage can prevent hydrocephalus and reduce iron levels in the choroid plexus. This treatment strategy may be clinically relevant for preventing neurological sequelae after intraventricular hemorrhage.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Pediatrics
Yi Dai, Li Zhu, Yequn Zhou, Chao Chen, Shulian Zhang
Summary: This study found an increasing trend in the incidence of retinopathy of prematurity among extremely preterm infants in a large neonatal care unit in China over the past 10 years. The increased survival rate and use of high-target oxygen saturation in the later period may partly explain this trend. Further investigations are needed to improve care practices and reduce the incidence of severe retinopathy of prematurity.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, General & Internal
Jae Hyun Park, Jin Gon Bae, Yun Sil Chang
Summary: The study showed that the latent period after preterm premature rupture of membrane did not significantly affect the survival rate of extremely preterm infants, but increased the risk of bronchopulmonary dysplasia occurrence.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Obstetrics & Gynecology
Gustavo Rocha, Sandra Pereira, Joao Antunes-Sarmento, Filipa Flor-de-Lima, Henrique Soares, Hercilia Guimaraes
Summary: This study found an association between anemia at admission and neonatal mortality and morbidity in ELBW infants, indicating the importance of preventive strategies for early anemia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Pediatrics
Emilie Groulx-Boivin, Mariane Paquette, May Khairy, Marc Beltempo, Roy Dudley, Amaryllis Ferrand, Mireille Guillot, Victoria Bizgu, Jarred Garfinkle
Summary: This study investigated the temporal evolution of post-hemorrhagic ventricular dilatation (PHVD) and compared neurodevelopmental impairments in newborns with different outcomes. The results showed that newborns with persistent PHVD without resolution are at higher risk for neurodevelopmental impairments, which may be due to larger ventricular dilatation.
PEDIATRIC RESEARCH
(2023)
Review
Clinical Neurology
Luis A. Robles, Victor Volovici
Summary: Primary intraventricular hemorrhage (PIVH) is a subtype of intraventricular hemorrhage (IVH) without hemorrhagic parenchymal component. A study analyzed characteristics of hypertensive PIVH, finding hypertension as the most common cause, followed by hemorrhage caused by vascular anomalies. Prognosis is poorer in patients with low Glasgow Coma Score, old age, hydrocephalus, or more extensive intraventricular bleeding.
NEUROSURGICAL REVIEW
(2022)
Article
Pediatrics
Amanda R. Liu, Dawn Gano, Yi Li, Mithun Diwakar, Jesse L. Courtier, Matthew A. Zapala
Summary: In premature infants, initial screening head ultrasounds are usually normal, and follow-up screening ultrasounds also tend to be normal. Abnormal findings are typically limited to grade 1 germinal matrix hemorrhage.
PEDIATRIC RADIOLOGY
(2022)
Article
Cell Biology
Pilar Alves-Martinez, Isabel Atienza-Navarro, Maria Vargas-Soria, Maria Jose Carranza-Naval, Carmen Infante-Garcia, Isabel Benavente-Fernandez, Angel Del Marco, Simon Lubian-Lopez, Monica Garcia-Alloza
Summary: Germinal matrix-intraventricular hemorrhage (GM-IVH) is a common intracranial hemorrhage in preterm infants, resulting in neurological disabilities. This study demonstrates the neuroprotective effects of caffeine in GM-IVH, including reduced brain atrophy, improved neuronal wellbeing, preserved neurogenesis, and decreased inflammation. Caffeine treatment also leads to significant improvements in learning and memory abilities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)