Journal
EUROPEAN JOURNAL OF HISTOCHEMISTRY
Volume 60, Issue 4, Pages 263-266Publisher
PAGEPRESS PUBL
DOI: 10.4081/ejh.2016.2724
Keywords
Placenta; HtrA1; fibronectin; fibrinoid; mesenchymal villi
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Funding
- Universita Politecnica delle Marche
- PRIN from Italian Ministry and Research and Instruction (MIUR)
- Polytechnic University of Marche, Italy
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High temperature requirement A1 (HtrA1) is a secreted protease involved in placental development. Fibronectin (FN) is involved in important process such as wound healing, cell adhesion and spreading, growth, migration, and differentiation. The purpose of this study was to analyse the expression patterns of HtrA1 in relationship to FN and to the key growth zones of placenta such as mesenchymal villi as well as cell islands and cell columns. We demonstrated that FN and HtrA1 are localized in the placental key growth zones suggesting a pivotal role in maintaining the balance among the molecules involved in the placental development and differentiation.
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