Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency

The future of cardiovascular clinical research in North America and beyond—addressing challenges and leveraging opportunities through unique academic and grassroots collaborations

(2015) Matthew T. Roe et al.   AMERICAN HEART JOURNAL

The Anatomy of Medical Research

(2015) Hamilton Moses et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pharmacologic Therapy for Pulmonary Arterial Hypertension in Adults

(2014) Darren B. Taichman et al.   CHEST

Informed Choice of Composite End Points in Cardiovascular Trials

(2014) G. Gomez et al.  

The importance of patient-reported outcomes: a call for their comprehensive integration in cardiovascular clinical trials

(2014) Stefan D. Anker et al.   EUROPEAN HEART JOURNAL

Competing risks analyses: objectives and approaches

(2014) Marcel Wolbers et al.   EUROPEAN HEART JOURNAL

Analysing recurrent hospitalizations in heart failure: a review of statistical methodology, with application to CHARM-Preserved

(2014) Jennifer K. Rogers et al.   EUROPEAN JOURNAL OF HEART FAILURE

Modelling recurrent events: a tutorial for analysis in epidemiology

(2014) Leila DAF Amorim et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Strategies to Reduce Heart Failure Readmissions

(2014) Elizabeth H. Bradley et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Implant-based multiparameter telemonitoring of patients with heart failure (IN-TIME): a randomised controlled trial

(2014) Gerhard Hindricks et al.   LANCET

Effect of Rosuvastatin on Repeat Heart Failure Hospitalizations

(2014) Jennifer K. Rogers et al.   JACC-Heart Failure

Clinical outcome endpoints in heart failure trials: a European Society of Cardiology Heart Failure Association consensus document

(2013) Faiez Zannad et al.   EUROPEAN JOURNAL OF HEART FAILURE

Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction

(2013) Margaret M. Redfield et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The disconnect between phase II and phase III trials of drugs for heart failure

(2013) Muthiah Vaduganathan et al.   Nature Reviews Cardiology

A Path Forward on Medicare Readmissions

(2013) Karen E. Joynt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Opportunities and challenges of combined effect measures based on prioritized outcomes

(2013) Geraldine Rauch et al.   STATISTICS IN MEDICINE

Effect of Levosimendan on the Short-Term Clinical Course of Patients With Acutely Decompensated Heart Failure

(2013) Milton Packer et al.   JACC-Heart Failure

Use of alternative methodologies for evaluation of composite end points in trials of therapies for critical limb ischemia

(2012) Sumeet Subherwal et al.   AMERICAN HEART JOURNAL

Eplerenone in Patients With Systolic Heart Failure and Mild Symptoms

(2012) Jennifer K. Rogers et al.   CIRCULATION

Adaptive Licensing: Taking the Next Step in the Evolution of Drug Approval

(2012) H-G Eichler et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Heart rate at baseline influences the effect of ivabradine on cardiovascular outcomes in chronic heart failure: analysis from the SHIFT study

(2012) Michael Böhm et al.   Clinical Research in Cardiology

Time to move on from 'time-to-first': should all events be included in the analysis of clinical trials?

(2012) S. D. Anker et al.   EUROPEAN HEART JOURNAL

Effect of ivabradine on recurrent hospitalization for worsening heart failure in patients with chronic systolic heart failure: the SHIFT Study

(2012) J. S. Borer et al.   EUROPEAN HEART JOURNAL

Designing and Analyzing Clinical Trials with Composite Outcomes: Consideration of Possible Treatment Differences between the Individual Outcomes

(2012) Janice Pogue et al.   PLoS One

Refining clinical trial composite outcomes: An application to the Assessment of the Safety and Efficacy of a New Thrombolytic–3 (ASSENT-3) trial

(2011) Paul W. Armstrong et al.   AMERICAN HEART JOURNAL

The win ratio: a new approach to the analysis of composite endpoints in clinical trials based on clinical priorities

(2011) S. J. Pocock et al.   EUROPEAN HEART JOURNAL

Link between decisions regarding resuscitation and preferences for quality over length of life with heart failure

(2011) Sandesh Dev et al.   EUROPEAN JOURNAL OF HEART FAILURE

Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial

(2011) William T Abraham et al.   LANCET

Testing for heterogeneity among the components of a binary composite outcome in a clinical trial

(2010) Janice Pogue et al.   BMC Medical Research Methodology

Lifetime Costs of Medical Care After Heart Failure Diagnosis

(2010) Shannon M. Dunlay et al.  

Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study

(2010) Karl Swedberg et al.   LANCET

Generalized pairwise comparisons of prioritized outcomes in the two-sample problem

(2010) Marc Buyse   STATISTICS IN MEDICINE

Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal

(2010) David M Kent et al.   Trials

Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)

(2009) et al.   EUROPEAN HEART JOURNAL

Selecting Patients for Cardiac Resynchronization Therapy

(2009) Nathaniel M. Hawkins et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Changing Preferences for Survival After Hospitalization With Advanced Heart Failure

(2008) Lynne W. Stevenson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY