Article
Chemistry, Organic
Mona Jalali, Alex C. Bissember, Brian F. Yates, Sarah E. Wengryniuk, Alireza Ariafard
Summary: The study revealed that Bi(N)-HVIs compounds can achieve oxidative dearomatization of electron-poor phenols, and explored the reaction mechanism using density functional theory, finding that the key step in the reaction is the first redox process, with the choice of ligands at the iodine(V) center significantly affecting the reaction rate.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Astronomy & Astrophysics
Nobuhiro Okabe, Simon Dicker, Dominique Eckert, Tony Mroczkowski, Fabio Gastaldello, Yen-Ting Lin, Mark Devlin, Charles E. Romero, Mark Birkinshaw, Craig Sarazin, Cathy Horellou, Tetsu Kitayama, Keiichi Umetsu, Mauro Sereno, Brian S. Mason, John A. ZuHone, Ayaka Honda, Hiroki Akamatsu, I-Non Chiu, Kotaro Kohno, Kai-Yang Lin, Elinor Medezinski, Satoshi Miyazaki, Ikuyuki Mitsuishi, Atsushi J. Nishizawa, Masamune Oguri, Naomi Ota, Florian Pacaud, Marguerite Pierre, Jonathan Sievers, Vernesa Smolcic, Sara Stanchfield, Keigo Tanaka, Ryoichi Yamamoto, Chong Yang, Atsushi Yoshida
Summary: This study presents simultaneous modeling results of high angular resolution Sunyaev-Zel'dovich effect (SZE) measurements and X-ray imaging of three rich galaxy clusters selected from the HSC-SSP Survey. The analysis reveals different characteristics in the gas properties distribution, such as a sloshing mode in one cluster, a residual cool core in another cluster, and a minor merger in a supercluster, suggesting that the S-X and y distributions are perturbed at some level regardless of optical properties.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2021)
Article
Cell Biology
Lejiao Mao, Chenyi Liao, Jiao Qin, Yanqiu Gong, Yifei Zhou, Shasha Li, Zhe Liu, Huaqing Deng, Wankun Deng, Qingxiang Sun, Xianming Mo, Yu Xue, Daniel D. Billadeau, Lunzhi Dai, Guohui Li, Da Jia
Summary: This study reveals that external stimuli such as starvation, LPS, and inflammatory cytokines can inhibit endocytic recycling of proteins by activating MAPK11/14, leading to a disruption in the balance between recycling and degradation. Stress-induced kinases phosphorylate SNX27 at Ser51, altering its binding with cargo proteins and thereby suppressing endocytic recycling. The findings suggest that cells can modulate endocytic recycling in response to stress signals, providing new insights into how cells cope with stress and conserve energy.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Zhu Han, Weizhi Zhang, Wanshan Ning, Chenwei Wang, Wankun Deng, Zhidan Li, Zehua Shang, Xiaofei Shen, Xiaohui Liu, Otto Baba, Tsuyoshi Morita, Lu Chen, Yu Xue, Da Jia
Summary: This study establishes a pipeline integrating computational and experimental approaches to demonstrate the frequent occurrence of altered autophagy selectivity in cancer cells and to link glycogen autophagy with tumourigenesis.
NATURE COMMUNICATIONS
(2021)
Letter
Cell Biology
Wenjie Huang, Xiaohui Ju, Min Tian, Xiaoyu Li, Yanying Yu, Qingxiang Sun, Qiang Ding, Da Jia
Article
Biochemistry & Molecular Biology
Yuping Tan, Xia Zhou, Yanqiu Gong, Kun Gou, Youfu Luo, Da Jia, Lunzhi Dai, Yinglan Zhao, Qingxiang Sun
Summary: The study identified a new PHGDH inhibitor, oridonin, and revealed the mechanism of its binding to PHGDH structure, providing new insights for the future design of PHGDH inhibitors.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jialin Yao, Yingfeng Tu, Congcong Shen, Qiao Zhou, Hengyi Xiao, Da Jia, Qingxiang Sun
Summary: The majority of long non-coding RNAs and a small fraction of messenger RNAs localize in the cell nucleus to exert their functions. A study found that the nuclear localization of SIRLOIN RNA is mediated by a complex of hnRNPK and Imp alpha 1, with the nuclear import receptors functioning as drivers/regulators and hnRNPK acting as an adaptor.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Chemistry, Medicinal
Song Liu, Wenliang Qiao, Qingxiang Sun, Youfu Luo
Summary: CRM1 functions as a major nuclear export receptor protein and plays a therapeutic role in various tumors. KPT-330, an inhibitor, has received FDA approval for multiple myeloma. This review summarizes the biological functions of CRM1, its role in cancer, the discovery of inhibitors, and aims to guide the future design and optimization of CRM1 inhibitors.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Yuying Li, Xinmin Yang, Linrui Peng, Qing Xia, Yuwei Zhang, Wei Huang, Tingting Liu, Da Jia
Summary: This study comprehensively summarizes the phenotypes, mechanisms, and treatment options of human diseases caused by BSCL2 gene mutations, as well as relevant findings in animal studies. Restoring adipose tissue function and targeting seipin-related pathways are effective strategies for CGL2 treatment and also have potential therapeutic value in other diseases.
Article
Chemistry, Medicinal
Wenxin Huang, Jia-Xi Wang, Xiaofei Shen, Yuqin Lei, Xueqin Chen, Da Jia, Xia Zhang, Qingxiang Sun
Summary: In this study, zafirlukast was identified as a new noncovalent CRM1 inhibitor through virtual screening of a library of marketed drugs. It was found to bind to four subpockets in the NES groove of CRM1. Zafirlukast effectively inhibited the growth of various cancer cells and worked synergistically with doxorubicin. These findings lay a foundation for further design of noncovalent, specific, and potent CRM1 inhibitors for cancer treatment.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Xin Yong, Guowen Jia, Zhe Liu, Chunzhuang Zhou, Jiamin Yi, Li Chen, Lu Chen, Yuan Wang, Qingxiang Sun, Daniel D. Billadeau, Zhaoming Su, Da Jia
Summary: In this study, the structure of the Drosophila Mon1-Ccz1-RMC1 complex was determined using cryogenic-electron microscopy. RMC1 acts as a scaffolding subunit and binds to both Mon1 and Ccz1, explaining the binding specificity of the complex. The assembly of RMC1 with Mon1-Ccz1 is required for cellular RAB7A activation, autophagic functions, and organismal development in zebrafish.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Medicinal
Lunan Jian, Robert Zscherp, Ulrike Beutling, Xiaofei Shen, Shiyang Xu, Xia Zhang, Mark Broenstrup, Philipp Klahn, Qingxiang Sun
Summary: In this study, four aminoratjadone derivatives were synthesized and two of them, KL1 and KL2, were found to be noncovalent CRM1 inhibitors. The compounds underwent spontaneous hydrolysis in aqueous buffers and the resulting products showed higher activity against CRM1. High-resolution crystal structures revealed the binding mode of these compounds to CRM1 and explained the structure-activity relationships. In cells, KL1 and KL2 localized CRM1 in the nuclear periphery and led to depletion of nuclear CRM1, thereby inhibiting the nuclear export and growth of colorectal cancer cells at submicromolar concentrations. This work lays the foundation for further development of aminoratjadone-based noncovalent CRM1 inhibitors.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Wenxin Huang, Jia-Xi Wang, Xiaofei Shen, Yuqin Lei, Xueqin Chen, Da Jia, Xia Zhang, Qingxiang Sun
Summary: Chromosomal region maintenance protein 1 (CRM1) is an established target for anticancer drugs, with the covalent inhibitor KPT-330 already on the market. However, the development of noncovalent CRM1 inhibitors is limited. In this study, zafirlukast, a marketed drug, was identified as a new noncovalent CRM1 inhibitor. It inhibited the growth of cancer cells and showed synergy with doxorubicin. This research provides a foundation for further designing noncovalent CRM1 inhibitors for cancer treatment.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Lin Zhao, Kunhong Zhong, Jia Zhao, Xin Yong, Aiping Tong, Da Jia
Summary: Research has shown that SARS-CoV-2 utilizes the interaction between SNX27 and the S protein to facilitate the expression of viral surface proteins, with the S protein binding to the PDZ domain of SNX27 for this process.
Article
Biochemistry & Molecular Biology
Zhe Liu, Yan Wang, Fan Yang, Qin Yang, Xianming Mo, Ezra Burstein, Da Jia, Xiao-Tang Cai, Yingfeng Tu
Summary: This study reports a case of CDG caused by GMPPB mutations, finding a correlation between GMPPB mutations, decreased glycosylation enzyme activity, and neurological and muscular phenotypes.
MOLECULAR BIOMEDICINE
(2021)
Letter
Biochemistry & Molecular Biology
Yuping Tan, Yuqing Zhang, Qiao Zhou, Da Jia, Qingxiang Sun
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)