Design, synthesis and biological evaluation of novel 5-(4-chlorophenyl)-4-phenyl-4H-1,2,4-triazole-3-thiols as an anticancer agent

p53: An Attractive Therapeutic Target for Cancer

(2019) Krupa R. Patel et al.   CURRENT MEDICINAL CHEMISTRY

Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction

(2017) Ewa Surmiak et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent Developments on 1,2,4-Triazole Nucleus in Anticancer Compounds: A Review

(2016) Ramandeep Kaur et al.   Anti-Cancer Agents in Medicinal Chemistry

TP53Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data

(2016) Liacine Bouaoun et al.   HUMAN MUTATION

How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures

(2015) Natalia Estrada-Ortiz et al.   ChemMedChem

Thioimidazoline based compounds reverse glucocorticoid resistance in human acute lymphoblastic leukemia xenografts

(2015) Cara E. Toscan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction

(2015) Mariell Pettersson et al.   PLoS One

Indications and limitations of chemotherapy and targeted agents in non-small cell lung cancer brain metastases

(2014) Stefan Zimmermann et al.   CANCER TREATMENT REVIEWS

Design, synthesis and biological evaluation of novel 3,4,5-trisubstituted aminothiophenes as inhibitors of p53–MDM2 interaction. Part 1

(2013) Weisi Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Discovery, Synthesis, and Biological Evaluation of Orally Active Pyrrolidone Derivatives as Novel Inhibitors of p53–MDM2 Protein–Protein Interaction

(2012) Chunlin Zhuang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Halogen Atoms in the Modern Medicinal Chemistry: Hints for the Drug Design

(2010) Marcelo Hernandes et al.   CURRENT DRUG TARGETS

Prediction of Absolute Solvation Free Energies using Molecular Dynamics Free Energy Perturbation and the OPLS Force Field

(2010) Devleena Shivakumar et al.   Journal of Chemical Theory and Computation

Identifying and Characterizing Binding Sites and Assessing Druggability

(2009) Thomas A. Halgren   Journal of Chemical Information and Modeling