Article
Immunology
Zhaolai Hua, Le Xu, Jiahui Zhu, Ling Xiao, Bin Lu, Jianping Wu, Zhenfeng Wu, Qihai Zhou, Junfeng Zhang
Summary: Objective of this study was to investigate the effect of Helicobacter pylori (Hp) infection on gastric mucosal microbiota in patients with chronic gastritis. The study found that virulent Hp infection alters gastric microbiota, reduces microbial diversity, and enhances the symbiotic relationship between Helicobacter bacteria and non-Helicobacter bacteria in patients with chronic gastritis. These findings provide new evidence for treating Hp infection by improving gastric microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Ying Chen, Shou-Yue Xia, Fu-Xia Ru, Jun-Jie Feng, Ji Tao, Zhi-Yuan Wei, Xiu Li, Chengjia Qian, Qiong Lin, Jian-Huan Chen
Summary: This study analyzed and compared the microbial communities and microbial interactive networks of gastric juice microbiota (GJM) in pediatric chronic gastritis (PCG) patients who tested positive and negative for Helicobacter pylori (HP). The results showed significant differences in beta diversity and taxonomic structure between HP+ and HP- PCG, with reduced microbial network connectivity in HP+ PCG. Function analysis indicated up-regulated pathways related to nucleotide metabolism, carbohydrate metabolism, and L-Lysine metabolism in HP+ PCG. These findings suggest that the alterations in GJM may be involved in the etiology of PCG.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
M. C. Mommersteeg, I Simovic, B. Yu, S. A. van Nieuwenburg, I. M. J. Bruno, M. Doukas, E. J. Kuipers, M. C. W. Spaander, M. P. Peppelenbosch, N. Castano-Rodriguez, G. M. Fuhler
Summary: The SNP in the ATG16L1 gene is associated with increased intestinal endoplasmic reticulum stress and progression of gastric cancer induced by H. pylori. Individuals with the G-allele are more prone to developing gastric cancer.
Review
Immunology
Yang Guo, Xue-Shan Cao, Meng-Ge Zhou, Bo Yu
Summary: Gastric cancer is a leading cause of cancer-related deaths worldwide. The gastric microbiota, including both Helicobacter pylori and non-H. pylori microbes, plays a critical role in the development of gastric cancer. Dysbiosis of the gastric microbiota, with a decrease in non-H. pylori microbes, occurs following H. pylori infection. As gastric lesions progress, there is a decrease in H. pylori and an increase in non-H. pylori microbes. The roles of H. pylori and non-H. pylori microbes differ at different stages of gastric carcinogenesis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Nutrition & Dietetics
Han-Na Kim, Min-Jeong Kim, Jonathan. P. P. Jacobs, Hyo-Joon Yang
Summary: This study investigated the microbial changes and host inflammatory cytokine responses in H. pylori-negative gastric cancer patients. The results showed that the gastric mucosal microbiota in GC patients had reduced diversity and a different composition compared to controls. Lacticaseibacillus was enriched, while Haemophilus and Campylobacter were depleted in the cancer group. Furthermore, the combined abundance of these taxa correlated significantly with gastric mucosal IL1B expression.
Editorial Material
Microbiology
Agustina Taglialegna
Summary: In this study, Sharafutdinov et al. report the identification of a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is linked to gastric cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Alain P. Gobert, Keith T. Wilson
Summary: Gastric cancer is the fifth most common cancer and the fourth most common cause of cancer-related death worldwide. The key factor in the development of gastric inflammation and disease progression is Helicobacter pylori infection, although only a small percentage of infected individuals develop gastric adenocarcinoma.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Microbiology
Mariagrazia Piscione, Mariangela Mazzone, Maria Carmela Di Marcantonio, Raffaella Muraro, Gabriella Mincione
Summary: Gastric cancer is the fifth most common cancer worldwide and the third leading cause of death in developed countries, mainly caused by Helicobacter pylori which is considered a type I carcinogen. The development of gastric cancer involves a progression from gastritis to intestinal metaplasia and eventual adenocarcinoma, with steps including chronic non-atrophic gastritis triggered by H. pylori infection.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Cheol Min Shin, Nayoung Kim, Ji Hyun Park, Dong Ho Lee
Summary: Helicobacter pylori infection alters gastric microbiota profiles, with changes observed in the relative abundance of different bacterial taxa. Eradication of H. pylori does not always lead to restoration of a healthy gastric microbiota. Aging also plays a role in shaping the gastric microbiota, with differences in microbial diversity and abundance observed in individuals over time.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Alain P. Gobert, Mohammad Asim, Thaddeus M. Smith, Kamery J. Williams, Daniel P. Barry, Margaret M. Allaman, Kara M. McNamara, Caroline V. Hawkins, Alberto G. Delgado, M. Blanca Piazuelo, John A. Rathmacher, Keith T. Wilson
Summary: Stomach cancer is a leading cause of cancer death, primarily caused by Helicobacter pylori infection, which induces inflammation and DNA damage. 2-hydroxybenzylamine (2-HOBA), derived from buckwheat seeds, is effective in reducing gastritis, gastric dysplasia, and carcinogenesis caused by H. pylori infection in mice and gastric epithelial cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Anna K. Miller, Gloria Tavera, Ricardo L. Dominguez, M. Constanza Camargo, Tim Waterboer, Keith T. Wilson, Scott M. Williams, Douglas R. Morgan
Summary: The primary cause of gastric cancer is chronic infection with Helicobacter pylori (H. pylori), particularly the high-risk genotype cagA, and risk modification by human genetic variants. Variants such as rs2302615 in ornithine decarboxylase (ODC1) are associated with gastric cancer risk.
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Review
Infectious Diseases
Marcello Fiorani, Ege Tohumcu, Livio Enrico Del Vecchio, Serena Porcari, Giovanni Cammarota, Antonio Gasbarrini, Gianluca Ianiro
Summary: Helicobacter pylori is a bacterium that colonizes the human stomach and is associated with various gastric and extra-gastric disorders. Colonization of H. pylori affects the gastric microenvironment and gastrointestinal microbiota by regulating factors such as acidity, immune responses, antimicrobial peptides, and virulence factors. Eradication therapies for H. pylori can negatively impact the gut microbiota, but integrating probiotics into the treatment has been shown to mitigate these effects and improve eradication rates and patient compliance. This article provides an overview of the complex interaction between H. pylori and the gastrointestinal microbiota, emphasizing the consequences of eradication therapies and the benefits of probiotic supplementation.
Article
Microbiology
Quanjiang Dong, Yongning Xin, Lili Wang, Xinying Meng, Xinjuan Yu, Linlin Lu, Shiying Xuan
CURRENT MICROBIOLOGY
(2017)
Review
Gastroenterology & Hepatology
Dawei Gong, Xiaojie Gong, Lili Wang, Xinjuan Yu, Quanjiang Dong
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2016)
Article
Oncology
Jianhua Zhou, Shengyun Huang, Lili Wang, Xiao Yuan, Quanjiang Dong, Dongsheng Zhang, Xuxia Wang
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2017)
Article
Medicine, Research & Experimental
Xin-Juan Yu, Xuan Yang, Lei Feng, Li-Li Wang, Quan-Jiang Dong
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2017)
Article
Biotechnology & Applied Microbiology
Jianhua Zhou, Xiaoli Gao, Shengyun Huang, Li Ma, Yanjun Cui, Hengkun Wang, Jianzhong Qiu, Lili Wang, Quanjiang Dong, Zhenggang Chen, Xuxia Wang, Dongsheng Zhang
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Medicine, Research & Experimental
Lili Wang, Shuhui Zhan, Jianhua Zhou, Jingjing Huang, Xinjuan Yu, Kaixin Dong, Quanjiang Dong
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2014)
Article
Oncology
Jianhua Zhou, Lili Wang, Zhenggang Chen, Jianzhong Qiu, Quanjiang Dong
Article
Medicine, Research & Experimental
Xinjuan Yu, Zhengqiang Wang, Lili Wang, Xinying Meng, Changhong Zhou, Yongning Xin, Weili Sun, Quanjiang Dong
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2020)
Article
Microbiology
Lili Wang, Yongning Xin, Jianhua Zhou, Zibin Tian, Chenguang Liu, Xinjuan Yu, Xinying Meng, Weina Jiang, Shoufeng Zhao, Quanjiang Dong
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Oncology
Jianhua Zhou, Lili Wang, Rongtao Yuan, Xinjuan Yu, Zhenggang Chen, Fang Yang, Guirong Sun, Quanjiang Dong
CANCER MANAGEMENT AND RESEARCH
(2020)
Review
Oncology
Zhi-Peng Li, Ju-Xin Liu, Lin-Lin Lu, Li-Li Wang, Lin Xu, Zong-Hao Guo, Quan-Jiang Dong
Summary: Dysbiosis of the gastric microbiome is linked to the development of gastric cancer, with an increase in the abundance of Lactobacillus playing a significant role. Further studies examining the specific role of Lactobacillus in gastric carcinogenesis are needed to fully understand its impact.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Oncology
Xiao-Yu Wang, Li-Li Wang, Shu-Zhen Liang, Chao Yang, Lin Xu, Meng-Chao Yu, Yi-Xuan Wang, Quan-Jiang Dong
Summary: This study evaluated the performance of a polygenic risk score (PRS) based on H. pylori SNPs in predicting the risk of gastric cancer. The PRS model showed good predictive power for gastric cancer risk. It also demonstrated good performance in predicting cancer risk for hpEurope strains.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
L. L. Wang, J-X Liu, X-J Yu, J-L Si, Y-X Zhai, Q-J Dong
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2018)
Review
Medicine, Research & Experimental
Quan-Jiang Dong, Li-Li Wang, Yong-Ning Xin, Chao Yang, Xin-Juan Yu, Lin-Lin Lu, Shi-Ying Xuan
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2016)