Deoxypodophyllotoxin Inhibits Cell Growth and Induces Apoptosis by Blocking EGFR and MET in Gefitinib-Resistant Non-Small Cell Lung Cancer

Plumbagin engenders apoptosis in lung cancer cells via caspase-9 activation and targeting mitochondrial-mediated ROS induction

(2020) Surya Kant Tripathi et al.   ARCHIVES OF PHARMACAL RESEARCH

Isolation, Semisynthesis, and Molecular Modeling of Deoxypodophyllotoxin Analogs for an Anti‐oral Cancer Agent

(2020) Eunae Kim et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Deoxypodophyllotoxin inhibits cell viability and invasion by blocking the PI3K/Akt signaling pathway in human glioblastoma cells

(2019) Wei Wang et al.   ONCOLOGY REPORTS

Gefitinib exposure and occurrence of interstitial lung disease in Japanese patients with non-small-cell lung cancer

(2019) Toshio Kawata et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science

(2019) Yuening Xiang et al.   Cancer Medicine

Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer

(2019) Alessandro Leonetti et al.   BRITISH JOURNAL OF CANCER

Licochalcone B inhibits growth and induces apoptosis of human non-small-cell lung cancer cells by dual targeting of EGFR and MET

(2019) Ha-Na Oh et al.   PHYTOMEDICINE

Diosgenin Suppresses Cholangiocarcinoma Cells Via Inducing Cell Cycle Arrest And Mitochondria-Mediated Apoptosis

(2019) Xiao-Mei Mao et al.   OncoTargets and Therapy

Inhibition of Lung Cancer Proliferation by Wogonin is Associated with the Activation of Apoptosis and Generation of Reactive Oxygen Species

(2019) Chengyang Wang et al.   Balkan Medical Journal

MiR-181a contributes gefitinib resistance in non-small cell lung cancer cells by targeting GAS7

(2018) Wei Ping et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Predicting Antitumor Effect of Deoxypodophyllotoxin in NCI-H460 Tumor-Bearing Mice on the Basis of In Vitro Pharmacodynamics and a Physiologically Based Pharmacokinetic-Pharmacodynamic Model

(2018) Yang Chen et al.   DRUG METABOLISM AND DISPOSITION

Anthricin‑induced caspase‑dependent apoptosis through IGF1R/PI3K/AKT pathway inhibition in A549 human non‑small lung cancer cells

(2018) Bo‑Ram Park et al.   ONCOLOGY REPORTS

Biochanin A Induces S Phase Arrest and Apoptosis in Lung Cancer Cells

(2018) Yan Li et al.   Biomed Research International

Apoptosis Induction via ATM Phosphorylation, Cell Cycle Arrest, and ER Stress by Goniothalamin and Chemodrugs Combined Effects on Breast Cancer-Derived MDA-MB-231 Cells

(2018) Patompong Khaw-on et al.   Biomed Research International

Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer

(2017) Guangbo Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of casein kinase 2 blocks G2/M transition in early embryo mitosis but not in oocyte meiosis in mouse

(2017) Fei LIN et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Combination Osimertinib and Gefitinib in C797S and T790M EGFR- Mutated Non–Small Cell Lung Cancer

(2017) Surein Arulananda et al.   Journal of Thoracic Oncology

Induction of G2/M phase arrest and apoptosis by ZGDHU-1 in A549 and RERF-LC-MA lung cancer cells

(2016) Xinfeng Shen et al.   Oncology Letters

Dual inhibition of EGFR and MET induces synthetic lethality in triple-negative breast cancer cells through downregulation of ribosomal protein S6

(2015) YONG WEON YI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Deoxypodophyllotoxin Induces G2/M Cell Cycle Arrest and Apoptosis in SGC-7901 Cells and Inhibits Tumor Growth in Vivo

(2015) Yu-Rong Wang et al.   MOLECULES

Antineoplastic effects of deoxypodophyllotoxin, a potent cytotoxic agent of plant origin, on glioblastoma U-87 MG and SF126 cells

(2015) Mounia Guerram et al.   Pharmacological Reports

ω-Hydroxyundec-9-enoic acid induces apoptosis through ROS-mediated endoplasmic reticulum stress in non-small cell lung cancer cells

(2014) Kyung Mi Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The endoplasmic reticulum stress markers GRP78 and CHOP predict disease-free survival and responsiveness to chemotherapy in breast cancer

(2014) Yi-Zi Zheng et al.   BREAST CANCER RESEARCH AND TREATMENT

Economic Outcomes of Maintenance Gefitinib for Locally Advanced/Metastatic Non-Small-Cell Lung Cancer with Unknown EGFR Mutations: A Semi-Markov Model Analysis

(2014) Xiaohui Zeng et al.   PLoS One

Deoxypodophyllotoxin triggers necroptosis in human non-small cell lung cancer NCI-H460 cells

(2013) Meijuan Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells

(2013) Yan-Cong Li et al.   CANCER LETTERS

Validated LC–MS/MS assay for quantitative determination of deoxypodophyllotoxin in rat plasma and its application in pharmacokinetic study

(2013) Yang Yang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells

(2009) Soon Young Shin et al.   CANCER LETTERS

The safety and efficacy of gefitinib versus platinum-based doublets chemotherapy as the first-line treatment for advanced non-small-cell lung cancer patients in East Asia: A meta-analysis

(2008) Chia-Hsuin Chang et al.   LUNG CANCER