Article
Ophthalmology
Angelica C. Scanzera, Elmer Y. Tu, Charlotte E. Joslin
Summary: The study aimed to explore whether orthokeratology may increase the frequency of Acanthamoeba keratitis compared with other lens modalities. Findings showed that the proportion of orthokeratology cases among AK minors exceeded the expected proportion based on market penetrance, suggesting a potential increased risk of AK in orthokeratology users.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2021)
Article
Microbiology
Yu-Jen Wang, Sung-Chou Li, Wei-Chen Lin, Fu-Chin Huang
Summary: This study reveals the abundant anaerobic Gram-positive rods present in severe keratitis isolate and characterizes the association between Acanthamoeba and ocular flora in AK progression. Further analysis shows that Blautia producta is positively correlated with the disease course, while Bacteroides ovatus is abundant in early-stage keratitis isolates.
Article
Ophthalmology
Tao Tang, Xuewei Li, Sitong Chen, Qiong Xu, Heng Zhao, Kai Wang, Yan Li, Mingwei Zhao
Summary: The study investigates the ocular biological characteristics of myopic children with axial length (AL) reduction during Ortho-K treatment and provides clinical clues for better myopia control effects. After one year of Ortho-K treatment, children in the AL reduction group had decreased ACD, thickened CLT, thinned VCD, and smaller TZ compared to the AL elongation group.
Article
Microbiology
Allison Campolo, Brian Patterson, Esther Lara, Paul Shannon, Monica Crary
Summary: Acanthamoeba keratitis is a challenging infection of the cornea, and understanding the behavior of Acanthamoebae during contact lens use and disinfection can provide insights into their colonization and the efficacy of contact lens care solutions. In this study, Acanthamoeba behavior during and after disinfection with different contact lens care solutions was examined. The results showed that all contact lens care solutions significantly impacted Acanthamoeba motility, with the solution containing PHMB showing the most effectiveness. Post-disinfection, Acanthamoebae were observed to regain motility and travel considerable distances, posing a potential risk to ocular health.
Article
Microbiology
Rhonda Walters, Allison Campolo, Elise Miller, Cindy McAnally, Manal Gabriel, Paul Shannon, Monica Crary
Summary: The efficacy of preservative-free disinfection systems against bacteria, fungi, and Acanthamoeba was evaluated. Clear Care and Clear Care Plus showed significantly greater disinfection efficacy against Acanthamoeba compared to the povidone-iodine-based Cleadew system. The antimicrobial efficacy was maintained regardless of the presence of contact lenses.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Edyta B. Hendiger, Marcin Padzik, Ines Sifaoui, Maria Reyes-Batlle, Atteneri Lopez-Arencibia, Diana Zyskowska, Marta Grodzik, Anna Pietruczuk-Padzik, Jacek Hendiger, Gabriela Oledzka, Lidia Chomicz, Jose E. Pinero, Jacob Lorenzo-Morales
Summary: Acanthamoeba keratitis is a severe corneal infection that can be effectively reduced by incorporating silver nanoparticles into contact lens solutions without increasing cytotoxicity.
Review
Ophthalmology
Lauren Jeang, Sonal S. Tuli
Summary: This review examines the current literature and practice patterns of antimicrobial therapy for contact lens-related microbial keratitis (CLMK). The use of topical antimicrobials is the mainstay of treatment for corneal ulcers, but bacterial, fungal, and acanthamoeba ulcers present different challenges due to resistance and the lack of effective topical medications. Novel therapies and diagnostic procedures offer hope for improved treatment outcomes. Contact lens-associated microbial keratitis is a significant health issue that can cause vision loss.
CURRENT OPINION IN OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Fiona Stapleton, Chris H. L. Lim, Suhyun Kweon, Donald Tan, Jodhbir S. Mehta
Summary: Cosmetic contact lens related corneal infections in Asia account for a significant proportion of overall cases, predominantly affecting young females who wear hydrogel lenses.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Jianxia Fang, Zhu Huang, Yan Long, Miaomiao Zhu, Qin Wu, Xiaojun Chen, Wei Xv, Chixin Du
Summary: This study compared the effectiveness of multifocal soft contact lenses (MFSCLs), orthokeratology contact lenses (Ortho-kCLs), and single vision spectacles (SVSs) for myopia control. The results showed that wearing MFSCLs and Ortho-kCLs significantly delayed myopia progression compared to SVSs.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2022)
Article
Microbiology
Marcin Padzik, Lidia Chomicz, Julita Bluszcz, Karolina Maleszewska, Jaroslaw Grobelny, David Bruce Conn, Edyta B. Hendiger
Summary: Acanthamoeba spp. can cause Acanthamoeba keratitis, particularly in contact lens wearers. It has been found that silver nanoparticles combined with tannic acid-modified contact lens solutions can enhance their anti-adhesion activity with low cytotoxicity.
Article
Ophthalmology
Jimmy S. H. Tse, Jimmy K. W. Cheung, Gigi T. K. Wong, Thomas C. Lam, Kai Yip Choi, Katherine H. Y. So, Christie D. M. Lam, Andes Y. H. Sze, Angel C. K. Wong, Gigi M. C. Yee, Henry H. L. Chan
Summary: The study showed that Breath-O Correct orthokeratology lenses were safe and effective for refractive power reduction over a three-month period, with minor changes in tear proteome expression.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Ophthalmology
Nicole A. Carnt, Ryan E. K. Man, Eva K. Fenwick, Ecosse L. Lamoureux, Lisa J. Keay
Summary: This study found that AK has a significant and substantial impact on all three domains of VRQOL, regardless of sociodemographic factors. Patients with AK who experienced poor outcomes, British White race (compared to other races) and female, had lower VRQOL scores across all domains. Lower income patients with AK scored worse on Reading and Mobility domains, while those with lower education had poorer Emotional scores.
Article
Medicine, General & Internal
Weiwei Lu, Rui Ning, Kai Diao, Yang Ding, Ruru Chen, Lei Zhou, Yan Lian, Colm McAlinden, Francis W. B. Sanders, Fangfang Xia, Jinhai Huang, Wanqing Jin
Summary: This study compared the efficacy and safety of corneal refractive therapy (CRT) lenses and vision shaping treatment (VST) lenses for myopia control in children. The results showed that compared with VST lenses, CRT lenses had a weaker effect on myopia control but were safer. Different types of VST lenses had similar efficacy and safety in controlling myopia progression.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Nicole Carnt, Darwin C. Minassian, John K. G. Dart
Summary: This study aims to identify the risk factors for Acanthamoeba keratitis (AK) in daily disposable (DD) contact lens users compared to daily wear (DW) reusable lens users and specific risks for DD users. It is important because CL use is the main cause of microbial keratitis in many major economies, with AK accounting for approximately 50% of sight loss cases. Determining these AK risks informs practitioner advice and consumer behavior.
Article
Ophthalmology
Liyuan Sun, Xuewei Li, Heng Zhao, Yan Li, Kai Wang, Jia Qu, Mingwei Zhao
Summary: The purpose of this study was to investigate the relationship between patients' baseline biometric factors or lens parameters and the diameter of the treatment zone in young myopic children undergoing Corneal Refractive Therapy. Retrospective review of data from patients undergoing Corneal Refractive Therapy lens treatment within two years was conducted. Results showed that spherical refraction, flat keratometric reading, Reverse Zone Depth 2, Landing Zone Angle 1, and lens diameter were independent factors of treatment zone diameter. Logistic regression analysis accurately predicted the treatment zone size with a 71.5% accuracy.
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Cell Biology
Yu-Ting Xiao, Hua-Tao Xie, Xin Liu, Chao-Ye Duan, Jing-Yu Qu, Ming-Chang Zhang, Xin-Yue Zhao
Summary: The study demonstrates that subconjunctival injection of T-OMECs can help prevent corneal defects, opacity, and neovascularization, making it a potential novel strategy for treating LSCD.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2021)
Article
Ophthalmology
Yu-Ting Xiao, Xin-Yue Zhao, Xin Liu, Hua-Tao Xie, Ming-Chang Zhang
Summary: This is a 10-year follow-up case report on the use of APCS in a lamellar keratoplasty treatment. Results showed that APCS graft maintained good biocompatibility and physical properties, but some disadvantages were observed as well.
Article
Ophthalmology
Qian Li, Shu-Jie Jiao, Yue-Qi Wang, Hua-Tao Xie, Ming-Chang Zhang
Summary: In this study, we developed a tear lipid test strip coated with hydrophobic nano-silica for the detection of tear lipid. The strip showed good lipophilicity and hydrophobicity and could quantify tear lipid by measuring the length of lipid infiltration. The test strip demonstrated potential application in the diagnosis of dry eye.
Article
Ophthalmology
Wenhan Xu, Bin Kong, Huatao Xie, Jiaqi Zhang, Weijian Liu, Sheng Liu, Yanbin Zhang, Fan Yang, Jiheng Xiao, Shengli Mi, Liming Xiong, Mingchang Zhang, Fagang Jiang
Summary: In this study, a PCL/collagen scaffold was fabricated and found to have good mechanical and biological properties. It reduced keratocyte differentiation and fibrosis reaction, suggesting its potential therapeutic effect on corneal injury.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Materials Science, Biomaterials
Yingying Zhang, Zhixin Hu, Jingyu Qu, Huatao Xie, Jun Zhao, Tingjun Fan, Xin Liu, Mingchang Zhang
Summary: It has been found that seeding rabbit corneal endothelial cells on ultra-thin acellular porcine corneal stroma can enhance cell viability and function, resulting in the formation of a structure similar to Descemet's membrane. This provides a new possibility for endothelial keratoplasty.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Ophthalmology
Wen Geng, Jia-Song Wang, Bing-Jie Shi, Hua-Tao Xie, Ming-Chang Zhang
Summary: This study demonstrates that combined use of IFN alpha 2b and 5-FU as primary treatment for OSSN is safe and effective, with a short duration of administration and low recurrence rate.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Ophthalmology
Haihua Liu, Yiwen Cao, Ruiying Li, Jinfang Wu
Summary: This study developed and validated a nomogram for predicting the risk of second surgery in patients with concomitant esotropia (CE) and concluded that the proposed nomogram can serve as a predictive tool for prognostic evaluation of CE surgery.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Medicine, General & Internal
Hang Wong, Jia-Song Wang, Ya-Li Du, Hua-Tao Xie, Ming-Chang Zhang
Summary: This study evaluated the clinical outcome of Sandwich transplantation for recurrent pterygium with restrictive strabismus. The results showed that the procedure is safe and effective, with all patients achieving orthotropia at the last follow-up.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Malachie Ndikumukiza, Yu-Ting Xiao, You-Fan Ye, Jia-Song Wang, Xi Peng, Hua-Tao Xie, Ming-Chang Zhang
Summary: Blepharospasm patients with dry eye can be effectively managed through the combined treatment of Botulinum neurotoxin type A (BoNT-A) injection and absorbable punctal plug (APP) insertion. This retrospective study evaluated the efficacy of BoNT-A alone and BoNT-A plus APP in reducing functional impairment and improving dry eye symptoms. The results showed that both treatments were effective, but the combined treatment had a greater impact in terms of reducing ocular surface disease and fluorescein staining.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Microbiology
Jia-Song Wang, Ya-Li Du, Nan Deng, Xi Peng, Hang Wong, Hua-Tao Xie, Ming-Chang Zhang
Summary: This study aims to investigate the characteristics of in vitro culture and in vivo confocal microscopy (IVCM) in patients with fungal keratitis (FK) presented in a tertiary referral hospital in central China. The results showed that Fusarium species, Aspergillus species, and Alternaria species were the 3 most common isolated fungal pathogens in this hospital. IVCM was found to be positive for hyphae or spores in 96.8% of culture-positive cases. Different fungal species had different cultural characteristics and IVCM manifestations. In conclusion, identifying the IVCM image and cultural characteristics can contribute to rapid diagnosis and proper treatment of fungal keratitis.
Article
Medicine, General & Internal
Tian-Yu Yao, Jia-Song Wang, Wen Geng, Hua-Tao Xie, Ming-Chang Zhang
Summary: The study demonstrates the efficacy of conjunctival limbal autograft (CLAU) combined with amnion-assisted conjunctival epithelial redirection (ACER) procedure for patients with severe chemical burn induced unilateral total limbal stem cell deficiency (LSCD). The surgery restores visual function and alleviates the burden on patients and their families.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ya-Li Du, Xi Peng, Yang Liu, Jia-Song Wang, You-Fan Ye, Kang-Kang Xu, Jing-Yu Qu, Hua Chen, Hua-Tao Xie, Ming-Chang Zhang
Summary: Meibomian gland dysfunction (MGD) is a disorder of the meibomian glands that leads to changes in meibum secretion and is a major cause of evaporative dry eye (EDE). The obstruction of the gland orifice due to ductal epithelial hyperkeratinization and abnormal self-renewal and differentiation of acinar cells contribute to MGD pathogenesis.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Ophthalmology
Hua Chen, Hui Gao, Hua-Tao Xie, Shu-Ting Liu, Yu-Kan Huang, Ming-Chang Zhang
Summary: The study revealed that treatment with Staphylococcus aureus crude extracts (SACEs) led to overexpression of keratin 1 (Krt1) in the ducts and acini of meibomian gland (MG) explants, along with decreased viability and increased cell death. SACEs treatment also dose-dependently increased levels of pro-inflammatory cytokines in MG explants and activated the NF-kappa B and AIM2/ASC signaling pathways.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)