Review
Pharmacology & Pharmacy
Khaled Benchoula, Ishwar S. Parhar, Wong Eng Hwa
Summary: Obesity is a complex disease resulting from an imbalance between energy expenditure and food intake, with sedentary lifestyles and overeating contributing to a rise in obesity and type 2 diabetes cases. The mechanisms of these diseases and their interactions are still unclear, with ongoing research aiming to clarify these aspects. VGF peptide and its derivatives may play a role in the development of obesity and diabetes, though conflicting studies on the function of VGF have been reported.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Neurosciences
Kaitlin Murray, Kavi M. Rude, Jessica Sladek, Colin Reardon
Summary: Our study reveals that vagus nerve stimulation can inhibit inflammation, with efferent and afferent stimulation having distinct mechanisms. Immune regulation induced by vagus nerve stimulation is beta(2)-adrenergic receptor-dependent, suggesting unique pathways for controlling immune cell activation through efferent and afferent stimulation.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Chemistry, Analytical
Gregory Girardi, Danielle Zumpano, Noah Goshi, Helen Raybould, Erkin Seker
Summary: The gut-brain axis plays a crucial role in the communication between the gastrointestinal tract and the central nervous system. Vagal afferent neurons (VANs) act as sensors for gut-derived signals and are influenced by effector molecules released by the gut microbiota. This study presents a cell-based sensor, VAN culture, to monitor the influence of gastrointestinal effector molecules on neuronal behavior.
Review
Neurosciences
Valerie Y. H. van Weperen, Marmar Vaseghi
Summary: The control of cardiac sympathetic and parasympathetic tone plays a crucial role in regulating cardiac function. This control relies on sensory information transmitted from the heart to the central nervous system. The vagus nerve, which contains vagal cardiac afferent fibers, carries this sensory information to the brainstem. While vagal afferent signaling has been shown to increase parasympathetic response, it appears to change after cardiac injury, with many unknowns remaining. This review aims to summarize the current understanding of cardiac vagal afferent signaling in health and cardiovascular disease, particularly after myocardial infarction, and highlight remaining knowledge gaps.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Physiology
Emily Allen, Pott Pongpaopattanakul, Reshma A. Chauhan, Kieran E. Brack, G. Andre Ng
Summary: This study aimed to investigate the effects of electrical stimulation of the vagus nerve at varying parameters on NO release and cardiac electrophysiology using the isolated innervated rabbit heart preparation.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cell Biology
Stephanie C. Puente-Ruiz, Alexander Jais
Summary: This article discusses the reciprocal signaling mechanisms between the central nervous system and adipose tissue to maintain energy balance in the body. It focuses on the integration of external signals in neuronal populations of the hypothalamus and the regulation of adipose tissue function by the central nervous system.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Marian Kollarik, Fei Ru, Nikoleta Pavelkova, John Mulcahy, John Hunter, Bradley J. Undem
Summary: The study found that selective Na(V)1.7 blockers can effectively inhibit the C-wave of compound action potentials and parasympathetic cholinergic contractions in human isolated bronchi. In addition, Na(V)1.7 mRNA was found to be strongly expressed and transported down the vagus nerve bundles.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Dongxiao Zhang, Satoshi Yamaguchi, Xinhao Zhang, Boxuan Yang, Naoko Kurooka, Ryosuke Sugawara, Haya Hamed H. Albuayjan, Atsuko Nakatsuka, Jun Eguchi, Takeshi Y. Hiyama, Atsunori Kamiya, Jun Wada
Summary: miR-342-3p and its host gene Evl play critical roles in obesity and diabetes, targeting Snap25 to regulate food intake, suggesting the inhibition of miR-342-3p as a potential candidate for miRNA-based therapy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Peter Hanna, Michael J. Dacey, Jaclyn Brennan, Alison Moss, Shaina Robbins, Sirisha Achanta, Natalia P. Biscola, Mohammed A. Swid, Pradeep S. Rajendran, Shumpei Mori, Joseph E. Hadaya, Elizabeth H. Smith, Stanley G. Peirce, Jin Chen, Leif A. Havton, Zixi (Jack) Cheng, Rajanikanth Vadigepalli, James Schwaber, Robert L. Lux, Igor Efimov, John D. Tompkins, Donald B. Hoover, Jeffrey L. Ardell, Kalyanam Shivkumar
Summary: This study provides an in-depth examination of the innervation of the sinoatrial node by the right atrial ganglionated plexus in porcine and human hearts. It demonstrates the significant phenotypic diversity of neurons in the ganglionated plexus and their role in modulating cardiac function. The findings suggest that intrinsic cardiac neurons play a crucial role in controlling specific regions of the heart and could pave the way for targeted therapies in the future.
CIRCULATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Yue Wu, Jun Zhou, Yunfan Yang
Summary: This review explores the role of primary cilia and ciliopathies related to obesity. The article suggests that primary cilia play a significant role in metabolic regulation, particularly in the development of obesity and type 2 diabetes. Additionally, the review discusses the potential involvement of primary cilia in peripheral organs and central regulation of obesity, specifically focusing on the ciliary signaling in the hypothalamic control of feeding behavior. The proposed framework provides a basis for further investigation into the role of cilia in metabolic regulation.
JOURNAL OF GENETICS AND GENOMICS
(2023)
Article
Neurosciences
Jessica A. Fawley, Deborah M. Hegarty, Sue A. Aicher, Eric Beaumont, Michael C. Andresen
Summary: The study examined the synaptic characteristics of PVN-projecting NTS neurons in rat brainstem slices, revealing that these neurons receive direct and indirect information from the vagus nerve and are associated with TRPV1 expression.
Article
Cell Biology
Matthaus Metz, Marianna Beghini, Peter Wolf, Lorenz Pfleger, Martina Hackl, Magdalena Bastian, Angelika Freudenthaler, Jurgen Harreiter, Maximilian Zeyda, Sabina Baumgartner-Parzer, Rodrig Marculescu, Nara Marella, J. Thomas Hannich, Georg Gyori, Gabriela Berlakovich, Michael Roden, Michael Krebs, Robert Risti, Aivar Lookene, Michael Trauner, Alexandra Kautzky-Willer, Martin Krssak, Herbert Stangl, Clemens Furnsinn, Thomas Scherer
Summary: Studies have shown that recombinant human leptin can reduce hepatic lipid content by stimulating hepatic VLDL-TG secretion via the brain-vagus-liver axis, independent of food intake.
Article
Biochemistry & Molecular Biology
Katharina Scherschel, Hanna Braeuninger, Andrea Moelders, Nadine Erlenhardt, Ehsan Amin, Christiane Jungen, Ulrike Pape, Diana Lindner, Dane M. Chetkovich, Nikolaj Kloecker, Christian Meyer
Summary: TRIP8b has been found to play a role in modulating atrial electrophysiology in the intrinsic cardiac nervous system, potentially beyond its role in sino-nodal control of the heart. In vitro electrophysiological studies showed that TRIP8b-deficient mouse hearts exhibit increased refractory periods in certain areas, but no differences were observed in heart rate and ventricular refractory period between genotypes. Additionally, while Trip8b mRNA was detected in the ICNS, TRIP8b protein was not detectable.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Hui Li, Amanda J. Page
Summary: The vagus nerve is crucial in the bidirectional communication between the gut and the brain, and its dysfunction may contribute to functional dyspepsia. Understanding the alteration in vagal signaling and its pathophysiological roles may provide insights for new therapeutic treatments of this disorder.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Oncology
Francois Cherifi, Sophie Lefevre Arbogast, Jonaz Font, Cyril Abdeddaim, Stephanie Becourt, Nicolas Penel, Elodie Coquan, Justine Lequesne, Yori Gidron, Florence Joly
Summary: This study aimed to investigate the prognostic value of heart rate variability (HRV) in ovarian cancer (OC). The retrospective analysis of 202 OC patients showed that low HRV was associated with worse overall survival (OS). In multivariate analysis, low HRV remained an independent prognostic factor, with a two-fold higher risk of death among patients with low SDNN compared to those with high SDNN.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Shoko Suzumura, Kazuyo Tujioka, Takashi Yamada, Hidehiko Yokogoshi, Saori Akiduki, Yukihiro Hishida, Kazumi Tsutsui, Kazutoshi Hayase
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2015)
Article
Nutrition & Dietetics
Kazuyo Tujioka, Takashi Yamada, Hidehiko Yokogoshi, Saori Akiduki, Yukihiro Hishida, Kazumi Tsutsui, Kazutoshi Hayase
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Johko Hamuro, Yukihiro Hishida, Osamu Higuchi, Yuji Yamanashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2011)
Article
Biology
Haruka Matsuo, Ayaka Iwamoto, Tsuyoshi Otsuka, Yukihiro Hishida, Saori Akiduki, Mami Aoki, Mitsuhiro Furuse, Shinobu Yasuo
CHRONOBIOLOGY INTERNATIONAL
(2015)
Review
Immunology
Ryuichi Mashima, Yukihiro Hishida, Tohru Tezuka, Yuji Yamanashi
IMMUNOLOGICAL REVIEWS
(2009)
Article
Pharmacology & Pharmacy
Efi Nakazaki, Yasushi Yabuki, Hisanao Izumi, Yasuharu Shinoda, Fumiko Watanabe, Yukihiro Hishida, Ayako Kamimura, Kohji Fukunaga
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2019)
Article
Veterinary Sciences
Emi Taniguchi, Ayumi Hattori, Kaito Kurogi, Yukihiro Hishida, Fumiko Watanabe, Mitsuhiro Furuse, Shinobu Yasuo
Summary: The study found that L-ornithine can stimulate the release of GH in mice. After oral administration of L-ornithine, the increase in GH release was first observed 150 minutes later and lasted for more than 90 minutes. This increase was delayed compared to the reported levels of L-ornithine in plasma and tissues.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2022)
Article
Chemistry, Analytical
Yukihiro Hishida, Minako Nishi, Yukie Baba, Haruko Ikeuchi
ANALYTICAL SCIENCES
(2006)
