Acetylation of lactate dehydrogenase B drives NAFLD progression by impairing lactate clearance

Enzymatic and nonenzymatic protein acetylations control glycolysis process in liver diseases

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Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2018) Zobair M. Younossi et al.   HEPATOLOGY

Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease

(2018) Cynthia Lebeaupin et al.   JOURNAL OF HEPATOLOGY

Pyruvate dehydrogenase complex and lactate dehydrogenase are targets for therapy of acute liver failure

(2018) Rosa Ferriero et al.   JOURNAL OF HEPATOLOGY

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis

(2018) Yan-Xiao Ji et al.   NATURE MEDICINE

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease

(2017) Chris Estes et al.   HEPATOLOGY

Acid-base disorders in liver disease

(2017) Bernhard Scheiner et al.   JOURNAL OF HEPATOLOGY

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage

(2017) Xuanye Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactate clearance and mortality in septic patients with hepatic dysfunction

(2016) Tae Sun Ha et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease

(2016) Yaron Rotman et al.   GUT

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Aberrant lysine acetylation in tumorigenesis: Implications in the development of therapeutics

(2016) Stephanie Kaypee et al.   PHARMACOLOGY & THERAPEUTICS

Nonalcoholic Fatty Liver Disease

(2015) Mary E. Rinella   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Probing p300/CBP Associated Factor (PCAF)-Dependent Pathways with a Small Molecule Inhibitor

(2013) Rahul Modak et al.   ACS Chemical Biology

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

The metabolomic window into hepatobiliary disease

(2013) Diren Beyoğlu et al.   JOURNAL OF HEPATOLOGY

Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6

(2013) Rongya Tao et al.   JOURNAL OF LIPID RESEARCH

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Lactate metabolism in chronic liver disease

(2013) Johanne B. Jeppesen et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3

(2012) Ian M. Love et al.   CELL CYCLE

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

(2012) Tom Latham et al.   NUCLEIC ACIDS RESEARCH

Lactate kinetics in human tissues at rest and during exercise

(2010) Gerrit van Hall   Acta Physiologica

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

(2010) Hyun-Seok Kim et al.   Cell Metabolism

Plasma metabolomic profile in nonalcoholic fatty liver disease

(2010) Satish C. Kalhan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Animal models of nonalcoholic fatty liver disease

(2010) Lionel Hebbard et al.   Nature Reviews Gastroenterology & Hepatology

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Protein Acetylation Microarray Reveals that NuA4 Controls Key Metabolic Target Regulating Gluconeogenesis

(2009) Yu-yi Lin et al.   CELL

SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation

(2009) Chao Huang et al.   EMBO JOURNAL