Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 407, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jhazmat.2020.124871
Keywords
Emerging contaminants; Chiral; Biological effect; Health risk
Categories
Funding
- National Natural Science Foundation of China [21577075, 21707078]
- Major Science and Technology Program for Water Pollution Control and Treatment in China [2017ZX07202006]
- Natural Science Foundation of Guangdong Province [2020A151501229]
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The study revealed that the co-occurrence of ibuprofen and triclocarban residues in sediment have synergistic adverse effects on the environment and pose a synergistic threat to human health.
Residues of antiseptics and drugs have been ubiquitously detected in aquatic water-sediment systems, and are thus considered emerging contaminants that threaten our global environment. To investigate the potential risk of ibuprofen and triclocarban in sediment, effects of enzyme activity on the enantioselective degradation in sediment were investigated. Enantioselective fate of rac-ibuprofen was observed in sediment with R-enantiomer exhibiting preferential degradation. Enzyme evidence showed that high levels of triclocarban could significantly inhibit activities of catalase and urease activities in sediment, as well as increase the half-life of ibuprofen (from 5.8 d to 10.1 d). Cytotoxicity data suggested that cell growth processes were significantly affected by ibuprofen and triclocarban co-exposure, which was consistent with apoptosis results. Additionally, the expression of several proteins (Cyto-c, Nrf2, p62, Keap1, NQO1, and Pink1) were markedly induced upon exposure to ibuprofen in the presence of triclocarban. In conclusion, these findings illustrated that co-occurrence of ibuprofen and triclocarban residues have synergistic adverse effects to the environment and synergistically threaten human health.
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