Article
Medicine, General & Internal
Annette Haerdtlein, Anna Maria Boehmer, Katharina Karsten Dafonte, Marietta Rottenkolber, Ulrich Jaehde, Tobias Dreischulte
Summary: The study utilized two consensus processes to identify the most important ADEs leading to hospital admission and occurring during hospital stay. The results highlighted acute kidney injury, hypoglycemia, Stevens-Johnson syndrome, and rhabdomyolysis as the events of highest importance.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Amy W. Johnson, Lilian Golzarri Arroyo, Neetu Mahendraker, Jack Hosty, Kurt Kroenke
Summary: This study aimed to compare outcomes in patients with end-stage liver disease (ESLD) who received opioid analgesia to those who did not and to determine risk factors for adverse events (AEs). The results showed that patients who received opioids had more liver-related complications and higher rates of anxiety, along with worse pain scores. The opioid group had higher rates of respiratory and gastrointestinal AEs, but no increase in CNS adverse events. Anxiety and disease severity were risk factors for the number of AEs, while opioid administration was not an independent risk factor. Therefore, opioids have an appropriate and reasonably safe role in alleviating pain in patients with ESLD.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Geriatrics & Gerontology
Lorene Zerah, Severine Henrard, Ingeborg Wilting, Denis O'Mahony, Nicolas Rodondi, Olivia Dalleur, Kieran Dalton, Wilma Knol, Manuel Haschke, Anne Spinewine
Summary: DDIs are highly prevalent in older patients, with their prevalence increasing during hospitalization and then remaining stable over time; hyperpolypharmacy is the main factor predictive of changes in DDIs.
Article
Multidisciplinary Sciences
Eshetu Shiferaw Legesse, Oumer Sada Muhammed, Leja Hamza, Beshir Bedru Nasir, Teshome Nedi
Summary: This study aimed to assess medication-related problems (MRPs) and its associated factors among patients with chronic kidney disease (CKD). The study found that the most common MRP among CKD patients was the need for additional drug therapy.
Article
Health Care Sciences & Services
Whitney A. Kiker, Si Cheng, Lauren R. Pollack, Claire J. Creutzfeldt, Erin K. Kross, J. Randall Curtis, Katherine A. Belden, Roman Melamed, Donna Lee Armaignac, Smith F. Heavner, Amy B. Christie, Valerie M. Banner-Goodspeed, Ashish K. Khanna, Uluhan Sili, Harry L. Anderson, Vishakha Kumar, Allan Walkey, Rahul Kashyap, Ognjen Gajic, Juan Pablo Domecq, Nita Khandelwal
Summary: This study aimed to examine the intensity of care and related factors among hospitalized COVID-19 patients. The results showed that Full Code was the initial code status in the majority of patients, and it was more common among Black or Asian race, Hispanic ethnicity, and male patients. Additionally, minority patients were less likely to receive comfort measures only and more likely to receive CPR.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Article
Medicine, General & Internal
Diego San Jose-Saras, Jorge Vicente-Guijarro, Paulo Sousa, Paloma Moreno-Nunez, Jesus Maria Aranaz-Andres
Summary: This study aimed to analyze the association between inappropriate hospital admission and subsequent adverse events (AEs), and compare the clinical and economic implications of AEs after inappropriate admissions with appropriate admissions. The results showed that inappropriate admissions increased the risk of subsequent AEs and doubled the number of AEs per patient. AEs after inappropriate admissions were associated with scheduled admissions, prolonged ICU stays, and incurred significant cost overruns.
Article
Geriatrics & Gerontology
Shoshana J. Herzig, Timothy S. Anderson, Yoojin Jung, Long H. Ngo, Ellen P. McCarthy
Summary: Among Medicare beneficiaries aged 65 years and older hospitalized for a medical reason, there were 22,879 medical hospitalizations with at least one claim for an opioid within 2 days of discharge, and potential opioid-related ADEs occurred in 7.0%. Risk factors included older age, specific clinical conditions, red flags for opioid misuse, prior opioid use, and prescription of long-acting opioids.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Medicine, Research & Experimental
Lorena Martinez-Montesinos, Jose Miguel Rivera-Caravaca, Stefan Agewall, Eva Soler, Gregory Y. H. Lip, Francisco Marin, Vanessa Roldan
Summary: This study investigated the prevalence of polypharmacy, risk factors for polypharmacy, and the impact of polypharmacy on clinical outcomes in AF patients starting VKAs. It found that polypharmacy was associated with worse prognosis due to its association with bleeding and thromboembolic events.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Susan McCarroll, Pinar Avsar, Zena Moore, Tom O'Connor, Linda Nugent, Declan Patton
Summary: This systematic review aimed to determine the impact of specialist community palliative care teams (SCPCT) on the acute hospital admission rates in adult palliative care (PC) patients requiring End of Life Care (EOLC). The results showed that SCPCT had a positive impact in reducing hospital admissions, emergency department usage, and hospital death rates. However, further research is needed to ensure the accuracy of these findings.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2022)
Article
Public, Environmental & Occupational Health
Marian Krawczyk
Summary: This paper explores how hospital palliative clinicians anticipate and organize a patient's dying trajectory, framing their work as affective labour. The affective labour of clinicians plays a crucial role in organizing end-of-life care, including co-authoring disease trajectories and ensuring the naturalization of care direction and outcomes.
SOCIAL SCIENCE & MEDICINE
(2021)
Article
Health Care Sciences & Services
Nobutaka Ayani, Nozomu Oya, Riki Kitaoka, Akiko Kuwahara, Takeshi Morimoto, Mio Sakuma, Jin Narumoto
Summary: A study in four nursing homes for older people in Japan found that ADEs and MEs were common among elderly residents, with around one-third of ADEs being preventable. MEs were most frequently observed during the monitoring stage, with inadequate observation following physician's prescriptions being a common cause. Assessment and appropriate adjustment of medication preadmission and postadmission to nursing homes are needed to improve medication safety.
BMJ QUALITY & SAFETY
(2022)
Article
Anesthesiology
Scott Greenwald, George F. Chamoun, Nassib G. Chamoun, David Clain, Zhenyu Hong, Richard Jordan, Paul J. Manberg, Kamal Maheshwari, Daniel I. Sessler
Summary: This study developed and validated predictive tools based on diagnostic and procedural codes to predict adverse events and care utilization outcomes for hospitalized patients. The results showed that the predictive models had high accuracy and calibration strength, providing individualized risk profiles for patient management.
Article
Pharmacology & Pharmacy
Nobutaka Ayani, Takeshi Morimoto, Mio Sakuma, Toshiaki Kikuchi, Koichiro Watanabe, Jin Narumoto
Summary: The study revealed that antipsychotic polypharmacy (APP) may lead to adverse drug events (ADEs) in psychiatric inpatients, with the median number of ADEs significantly higher in patients with APP compared to those without.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Kuai In Tam, Sok Leng Che, Mingxia Zhu, Sok Man Leong
Summary: This study explored the preferred place of care and death for Chinese residents in Macao. The majority of respondents preferred to be cared for at home in the last 6 months, but only a small proportion preferred to die at home. A significant number of respondents chose hospices or hospitals as their preferred place of death. The study suggests the need for palliative home care services in Macao and emphasizes the importance of education for healthcare professionals.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Oncology
Nicole Heerde, Wolf-Karsten Hofmann, Ralf-Dieter Hofheinz, Sylvia Buettner, Deniz Gencer
Summary: In providing end-of-life care, physicians often have uncertainties, use sedatives more frequently, and administer fewer infusions for dying patients. Medical specialization is identified as an independent factor for good palliative practice, with doctors working with cancer patients more likely to provide quality end-of-life care. Guideline-based palliative care is implemented more consistently in oncology departments compared to non-oncological departments, highlighting potential training gaps.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
N. Molist-Brunet, D. Sevilla-Sanchez, J. Gonzalez-Bueno, V Garcia-Sanchez, L. A. Segura-Martin, C. Codina-Jane, J. Espaulella-Panicot
Summary: The study revealed that residents in nursing homes commonly face issues of polypharmacy and inappropriate prescriptions. Establishing individualized therapeutic goals can help detect 92.2% of inappropriate prescriptions. Frailer, functionally dependent, and end-of-life residents are more likely to receive inappropriate medication.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2021)
Article
Medicine, General & Internal
Jordi Amblas-Novellas, Scott A. Murray, Ramon Oller, Anna Torne, Joan Carles Martori, Sebastien Moine, Nadina Latorre-Vallbona, Joan Espaulella, Sebastia J. Santaeugenia, Xavier Gomez-Batiste
Summary: This study evaluated the frailty degree in older people towards the end of life with different advanced diseases, finding that the majority of end-of-life older people exhibited some degree of frailty, mostly advanced frailty. The degree of frailty was related to survival across different illness trajectories, despite varying survival patterns among trajectories. Frailty indexes may be useful in assessing end-of-life older people, regardless of their specific trajectory.
Article
Pharmacology & Pharmacy
J. Gonzalez-Bueno, D. Sevilla-Sanchez, E. Puigoriol-Juvanteny, N. Molist-Brunet, C. Codina-Jane, J. Espaulella-Panicot
Summary: The patient-centered prescription model improved medication adherence and effective prescribing in older patients with multimorbidity and polypharmacy. The intervention led to increased proportion of adherent patients, improved mean PDC, reduced number of long-term medications, decreased proportion of patients exposed to hyperpolypharmacy, simplified medication regimen complexity, and decreased potential inappropriate prescribing.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Environmental Sciences
Javier Gonzalez-Bueno, Daniel Sevilla-Sanchez, Emma Puigoriol-Juvanteny, Nuria Molist-Brunet, Carles Codina-Jane, Joan Espaulella-Panicot
Summary: This study focused on patients with multimorbidity and polypharmacy, finding that self-reported adherence and medication appropriateness are major determinants of medication non-adherence. Implementing targeted strategies based on these factors can improve effective prescribing in patients with multiple chronic conditions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Geriatrics & Gerontology
Marisa Bare, Marina Lleal, Sara Ortonobes, Maria Queralt Gorgas, Daniel Sevilla-Sanchez, Nuria Carballo, Elisabet De Jaime, Susana Herranz
Summary: The objectives of this study were to estimate the frequency of potentially inappropriate prescribing (PIP) at admission according to STOPP/START criteria in older patients hospitalized due to chronic disease exacerbation, and to identify risk factors associated with the most frequent inappropriate medications (PIMs). The study found that PIPs were highly prevalent in these patients, especially those involving proton pump inhibitors (PPIs) and benzodiazepines (BZDs).
Article
Pharmacology & Pharmacy
Ramon Fernandez Fernandez, Queralt Moreno Gil, Cecile Bessat, Pablo Roman, Daniel Sevilla-Sanchez
Summary: This study analyzed the suitability of the Model List of Essential Medicines for elderly patients and identified potential issues with drug prescription and possible additions to the list. The findings suggest that certain medications should be added to the next edition of the Model List to address therapeutic gaps.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2023)
Review
Environmental Sciences
Nuria Molist-Brunet, Daniel Sevilla-Sanchez, Emma Puigoriol-Juvanteny, Lorena Bajo-Penas, Immaculada Cantizano-Baldo, Laia Cabanas-Collell, Joan Espaulella-Panicot
Summary: This study compared the impact of place of residence (own home versus nursing home) on the characteristics of the baseline therapeutic plan and post-medication review (MR) therapeutic plan in older patients. The results showed that nursing home patients had a greater improvement in pharmacological parameters related to adverse events after an individualized MR.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Geriatrics & Gerontology
Nuria Molist-Brunet, Daniel Sevilla-Sanchez, Emma Puigoriol-Juvanteny, Matilde Barneto-Soto, Javier Gonzalez-Bueno, Joan Espaulella-Panicot
Summary: This study aimed to characterize a cohort of older adults with multimorbidity and carry out a medication review. The research found that an individualized medication review can significantly reduce polypharmacy, therapeutic complexity, and drug burden in older patients.
Article
Geriatrics & Gerontology
Jordi Amblas-Novellas, Anna Torne, Ramon Oller, Joan Carles Martori, Joan Espaulella, Roman Romero-Ortuno
Summary: This study aimed to characterize transitions in frailty before, during, and after admission to an intermediate care facility and assess their impact on health outcomes. The results showed that frailty status varied before and during admission, with frailty on admission being the strongest predictor of mortality. Routine frailty measurement on admission could aid clinical management decisions.
Article
Medicine, General & Internal
Manel Mata-Cases, Didac Mauricio, Jordi Real, Bogdan Vlacho, Laura Romera-Liebana, Nuria Molist-Brunet, Marta Cedenilla, Josep Franch-Nadal
Summary: This study assessed the potential risk of overtreatment in patients aged 75 years or older with type 2 diabetes in primary care. The results showed that one in four older adults treated with antidiabetic drugs associated with a high risk of hypoglycemia might be at risk of overtreatment. This risk is higher in those treated with sulfonylureas or glinides than with insulin.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Environmental Sciences
Marina Lleal, Marisa Bare, Sara Ortonobes, Daniel Sevilla-Sanchez, Rosa Jordana, Susana Herranz, Maria Queralt Gorgas, Mariona Espaulella-Ferrer, Marta Arellano, Marta de Antonio, Gloria Julia Nazco, Ruben Hernandez-Luis
Summary: This study analyzed the association between multimorbidity patterns and quality indicators of medication, finding a higher prevalence of potentially inappropriate prescribing and adverse drug reactions among multimorbid patients, which can guide specific medication review actions according to individual patient profiles.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Anna Ruiz-Comellas, Gloria Sauch Valmana, Queralt Miro Catalina, Isabel Gomez Baena, Jacobo Mendioroz Pena, Pere Roura Poch, Anna Sabata Carrera, Irene Cornet Pujol, Angels Casaldaliga Sola, Montserrat Fuste Gamisans, Carme Saldana Vila, Lorena Vazquez Abanades, Josep Vidal-Alaball
Summary: The percentage of older people worldwide is increasing, leading to a rise in loneliness and anxious-depressive states. This study found that participating in a 4-month moderate physical activity program in a group can improve the emotional state, levels of social support, and quality of life in individuals aged over 64.