Article
Agronomy
Tianyi Wang, Yunfei Li, Yumin Huang, Xiaoming Zhao, Zhaobin Dong, Weiwei Jin, Wei Huang
Summary: This study identified the positive regulatory role of ZmAAP6, a maize gene, in grain protein content (GPC) regulation. Mutant and overexpression analysis revealed its involvement in protein body formation and amino acid transportation.
Article
Multidisciplinary Sciences
Kimberlee P. Giffen, Yi Li, Huizhan Liu, Xiao-Chang Zhao, Chang-Jun Zhang, Ren-Juan Shen, Tianying Wang, Amanda Janesick, Bo-Bei Chen, Shu-Sheng Gong, Bechara Kachar, Zi-Bing Jin, David Z. He
Summary: This study reveals the role of autophagy-lysosomal dysfunction in syndromic hearing and vision loss in mice and humans caused by the mutation of SLC7A14 protein.
Article
Biochemistry & Molecular Biology
Yunjian Xu, Hui Bao, Hanting Fei, Wenqing Zhou, Xiaoyu Li, Fang Liu
Summary: Phosphate transporters like ZmPt9 play a significant role in phosphate uptake in plants, but this study suggests that ZmPt9 also influences plant growth and flowering in addition to its transport activity. Overexpressing ZmPt9 in Arabidopsis resulted in small leaves and early flowering, as well as complementing the late flowering phenotype of a mutant. Additionally, changes in expression levels of flowering-related genes and the influence of hormones like GA and auxin were observed, indicating the potential for ZmPt9 in improving crop growth.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Miku Sato, Narumi Harada-Shoji, Takafumi Toyohara, Tomoyoshi Soga, Masatoshi Itoh, Minoru Miyashita, Hiroshi Tada, Masakazu Amari, Naohiko Anzai, Shozo Furumoto, Takaaki Abe, Takashi Suzuki, Takanori Ishida, Hironobu Sasano
Summary: The study found that L-type amino acid transporter-1 (LAT1) plays an important role in therapeutic resistance and clinical outcomes of breast cancer. Glucose and amino acid metabolism were closely related, and in vitro experiments showed that LAT1 promoted amino acid uptake for energy production. Oncometabolites and branched-chain amino acids were also key players in energy production and drug resistance in chemotherapeutic-treated MCF-7 cells.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Gopal Kalwan, Parichita Priyadarshini, Kuldeep Kumar, Yashwant Kumar Yadava, Sheel Yadav, Deshika Kohli, Sarvajeet Singh Gill, Kishor Gaikwad, Venkatraman Hegde, Pradeep Kumar Jain
Summary: This study comprehensively analyzes the AAT gene family in chickpea and identifies 109 AAT genes, which play important roles in plant growth, stress resilience, and nutritional quality enhancement.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Ines Boehme-Schaefer, Sandra Loerentz, Anja Katrin Bosserhoff
Summary: This study reveals that the amino acid transporter SNAT1 is overexpressed in malignant melanoma and plays a crucial role in the proliferation, migration, invasion, and senescence of melanoma cells. Therefore, SNAT1 may be a potential target for melanoma therapy.
Article
Food Science & Technology
Li Tian, Zhaodi Ma, Hao Qiu, Xiaotian Liu, Tao Wu, Feng Ge, Rui Liu, Jing Zhu, Liang Shi, Ailiang Jiang, Hanshou Yu, Ang Ren
Summary: In this study, chitosan was used to improve the lysine content of Flammulina filiformis. Both AAT3 and AAT4 were found to play significant roles in the regulation of lysine biosynthesis induced by chitosan treatment.
Article
Multidisciplinary Sciences
Santosh K. Panda, Do-Hyun Kim, Pritesh Desai, Patrick F. Rodrigues, Raki Sudan, Susan Gilfillan, Marina Cella, Steven J. Van Dyken, Marco Colonna
Summary: ILC2 cells selectively express the Slc7a8 gene, which plays a crucial role in maintaining cellular fitness and activation. Lack of Slc7a8 leads to reduced amino acid availability, affecting energy metabolism and signaling pathway activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Agronomy
Songchong Lu, Xuan Ji, Xinshuang Zhang, Hao Wu, Yan Sun, Ying Zhu, Shanshan Su, Shumin Wei, Xin Liu
Summary: The cationic amino acid transporter NtCAT1 plays an important role in leaf senescence in tobacco. Overexpression of NtCAT1 accelerates leaf senescence, while the mutant ntcAT1-36 shows delayed senescence phenotype. NtCAT1 is involved in leaf senescence through regulating ABA biosynthesis and TOR kinase gene expression. Moreover, NtCAT1 transgenic plants exhibit significant changes in amino acid concentrations during leaf senescence.
Article
Genetics & Heredity
Md. Golam Rabby, Md. Munnaf Hossen, Md. Mostafa Kamal, Md. Numan Islam
Summary: This study identified and analyzed the lysine histidine transporter (LHT) gene family in maize, providing insights into their structure, evolutionary relationships, conserved motifs, and protein structure. The study also revealed distinct expression patterns of LHT genes in different tissues. These findings lay the foundation for further research on the function of LHT genes in maize and other crops.
Article
Biochemistry & Molecular Biology
Xuyao Zhao, Gaojie Li, Zuoliang Sun, Yan Chen, Wenjun Guo, Yixian Li, Yimeng Chen, Jingjing Yang, Hongwei Hou
Summary: The study identified that the PHT family members are highly conserved in duckweeds, and SpPHTs are involved in the phosphate signaling pathway and interact with components of the dopamine signal pathway. Overexpression experiments and bioinformatics analysis revealed that PHT genes respond to external stimuli and are significantly induced under phosphate starvation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Agriculture, Dairy & Animal Science
Teng Teng, Xin Song, Guodong Sun, Hongwei Ding, Haoyang Sun, Guangdong Bai, Baoming Shi
Summary: This study investigated the response of intestinal amino acid transport and the amino acid pool in muscle to chronic cold exposure in pig models. It was found that chronic cold exposure inhibited amino acid absorption and depleted branched amino acids in muscle. However, glucose supplementation improved amino acid transport and the amino acid pool in muscle.
Article
Food Science & Technology
Yungang Cao, Zhaorui Li, Baoling Li, Xin Fan, Miaomiao Liu, Jing Zhao
Summary: This study investigated the effects of sodium pyrophosphate (PP), Lysine (Lys), and their combination on the structure and gelling properties of oxidized myofibrillar protein (Ox-MP). The results showed that these additives modified protein structures, restored gel behavior, and significantly improved water holding capacity and breaking strength of heat-induced protein gels. The combination of PP and Lys had the most optimal effect.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dan Wang, Xuebin Wan, Xiaoli Du, Zhuxia Zhong, Jian Peng, Qi Xiong, Jin Chai, Siwen Jiang
Summary: The study reveals that leucine can increase the expressions of SLC38A9 and SLC36A1, leading to mTORC1 activation, and SLC38A9 interacts with SLC36A1 to enhance each other's expression levels and locations on the lysosomal surface. Interacting proteins of SLC38A9 in C2C12 cells are involved in amino acid sensing mechanism, mTORC1 signaling pathway, and protein synthesis, providing a resource for future investigations of skeletal muscle mass.
Article
Microbiology
Rabia Ramzan, Muhammad Safiullah Virk, Fusheng Chen
Summary: The transportation system of phenylacetic acid (PAA), a side chain of penicillin G (PG), in Monascus ruber M7 is not well understood. This study identified abct31 as a transporter potentially involved in PAA transportation. Furthermore, experiments demonstrated that L-cysteine (L-Cys), L-valine (L-Val), and PAA significantly impacted the morphologies and secondary metabolite production of M. ruber M7.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Plant Sciences
Xiaoyang Chen, Hua Zhang, Huayue Sun, Hongbing Luo, Li Zhao, Zhaobin Dong, Shuangshuang Yan, Cheng Zhao, Renyi Liu, Chunyan Xu, Song Li, Huabang Chen, Weiwei Jin
Article
Multidisciplinary Sciences
Qingzhu Zhang, Dong Wang, Zhaobo Lang, Li He, Lan Yang, Liang Zeng, Yanqiang Li, Cheng Zhao, Huan Huang, Heng Zhang, Huiming Zhang, Jian-Kang Zhu
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Cell Biology
Qingzhu Zhang, Yanqiang Li, Tao Xu, Ashish Kumar Srivastava, Dong Wang, Liang Zeng, Lan Yang, Li He, Heng Zhang, Zhimin Zheng, Dong-Lei Yang, Cheng Zhao, Juan Dong, Zhizhong Gong, Renyi Liu, Jian-Kang Zhu
Article
Plant Sciences
Dexuan Meng, Jianyu Zhao, Cheng Zhao, Haishan Luo, Mujiao Xie, Renyi Liu, Jinsheng Lai, Xiaolan Zhang, Weiwei Jin
Article
Multidisciplinary Sciences
Li He, Huan Huang, Mariem Bradai, Cheng Zhao, Yin You, Jun Ma, Lun Zhao, Rosa Lozano-Duran, Jian-Kang Zhu
Summary: DNA methylation plays a crucial role in plant development and gene regulation, and is essential for multiple biological processes.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Yves Mugabo, Cheng Zhao, Ju Jing Tan, Anindya Ghosh, Scott A. Campbell, Evgenia Fadzeyeva, Frederic Pare, Siew Siew Pan, Maria Galipeau, Julia Ast, Johannes Broichhagen, David J. Hodson, Erin E. Mulvihill, Sophie Petropoulos, Gareth E. Lim
Summary: While 14-3-3 proteins are crucial for neurotransmitter synthesis, specific isoform 14-3-3i; plays a critical role in regulating beta cell function by enhancing glucose-stimulated insulin secretion, mitochondrial function, and ATP synthesis. Deletion or inhibition of 14-3-3i; leads to alterations in beta cell transcriptome, particularly upregulating genes associated with mitochondrial respiration and oxidative phosphorylation, suggesting its importance in insulin secretion control.
Article
Multidisciplinary Sciences
Li He, Cheng Zhao, Qingzhu Zhang, Gaurav Zinta, Dong Wang, Rosa Lozano-Duran, Jian-Kang Zhu
Summary: The dysfunction of chromatin remodeler DDM1 was found to cause a switch in DNA methylation dependency from CMT2 to RdDM, impacting the stability of long transposable elements. The combined function of DDM1 and RdDM pathways is crucial for maintaining genomic stability.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)