Article
Multidisciplinary Sciences
Xuting Liu, Wei Wei, Zixuan Liu, Erqun Song, Jianlin Lou, Lingfang Feng, Rongchong Huang, Chunying Chen, Pu Chun Ke, Yang Song
Summary: This study found that upon respiratory exposure to silica nanoparticles (SiNPs), mice exhibited on-site cardiovascular damage. SiNPs adsorbed apolipoprotein A-I (Apo A-I) to mitigate toxic effects, but eventually depleted Apo A-I leading to unexpected toxic effects. The findings suggest a potential mechanism for the cardiovascular effects of nanoparticles.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Pharmacology & Pharmacy
Girish Kumar, Tarun Virmani, Ashwani Sharma, Kamla Pathak
Summary: Monotherapy with anticancer drugs is inefficient for treating cancer due to its heterogeneous nature, drug resistance, and adverse effects. Plant-based phytochemicals offer a better alternative to traditional chemotherapy due to their lower adverse effects, diverse action pathways, and lower costs. Combining phytochemicals with conventional anticancer drugs has shown greater efficacy in preclinical studies. However, poor solubility and bioavailability of phytochemicals need to be addressed. Therefore, nanotechnology-based carriers, such as nanoemulsion, nanosuspension, and polymeric nanoparticles, are employed for co-delivery of phytochemicals and anticancer drugs to improve the treatment of cancer.
Review
Pharmacology & Pharmacy
Nolwenn Tessier, Fatma Moawad, Nada Amri, Davide Brambilla, Catherine Martel
Summary: The focus is shifting towards other administration options with reduced dosing frequency and more efficacy in cardiovascular disease therapy, with increasing attention on drug delivery through the lymphatic route to avoid hepatic first-pass effect.
Article
Multidisciplinary Sciences
Qianqian Bai, Yu Xiao, Huiling Hong, Xiaoyun Cao, Lei Zhang, Ruifang Han, Leo Kit Cheung Lee, Evelyn Y. Xue, Xiao Yu Tian, Chung Hang Jonathan Choi
Summary: This study demonstrates the use of a three-dimensional nanostructure for delivering therapeutic oligonucleotides to atherosclerotic plaques. The nanoparticles target specific cells in the plaques and modulate genes related to plaque formation and inflammation, resulting in reduced and stabilized plaques without severe toxicity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cardiac & Cardiovascular Systems
Anthony Matta, Jean Pierre Rabes, Dorota Taraszkiewicz, Didier Carrie, Jerome Roncalli, Jean Ferrieres
Summary: This study evaluated the predictive effect of a causative genetic variant on cardiovascular events in HFH patients undergoing treatment and found that the presence of the variant did not independently predict the occurrence of cardiovascular diseases in HFH patients, while low-density lipoprotein cholesterol level played a decisive role.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Helen Williams, Corinne D. Mack, Stephen C. H. Li, John P. Fletcher, Heather J. Medbury
Summary: Monocytes play a crucial role in cardiovascular disease by infiltrating vessel walls to form atherosclerotic plaques. Different subsets of monocytes, including intermediate and nonclassical, have been associated with CVD and changes in inflammatory markers. Dyslipidemia can impact monocyte proportion and function, with lipid lowering medication showing some effect in reversing these changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Rodrigo dos A. Miguel, Amanda S. Hirata, Paula C. Jimenez, Luciana B. Lopes, Leticia V. Costa-Lotufo
Summary: Nature is a rich source of medicinal compounds like doxorubicin (DOX) and paclitaxel (PTX). Nanoformulations of these drugs are cost-effective and offer improved pharmacokinetic properties and targeted delivery, resulting in reduced side effects. They can also overcome drug resistance and allow for multi-drug encapsulation for combined chemotherapy.
Review
Pharmacology & Pharmacy
Fariba Mollarasouli, Ulya Badilli, Nurgul K. Bakirhan, Sibel A. Ozkan, Yalcin Ozkan
Summary: DNA nanotechnology combines DNA with nanomaterials to fabricate nanoscale devices and structures with potential drug delivery and biosensing applications. The development of DNA nanotechnologies, such as DNA nanomachines, has attracted increasing attention due to their small sizes and high biocompatibility, allowing the creation of hybrid delivery structures.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Nutrition & Dietetics
A. Munoz-Cabrejas, M. Laclaustra, P. Guallar-Castillon, J. A. Casasnovas, E. Jarauta, H. Sandoval-Insausti, C. Donat-Vargas, B. Moreno-Franco
Summary: The study found that among middle-aged males, a high intake of high-quality carbohydrates is negatively associated with the prevalence of femoral artery subclinical atherosclerosis, but not with carotid artery subclinical atherosclerosis. Additionally, a lower intake of high-quality carbohydrates is associated with a greater extension of atherosclerosis.
CLINICAL NUTRITION
(2021)
Article
Peripheral Vascular Disease
William B. Earle, Jordan K. Kondo, Karla N. Kendrick, Ruth-Alma Turkson-Ocran, Long Ngo, Jennifer L. Cluett, Kenneth J. Mukamal, Natalie Daya Malek, Elizabeth Selvin, Pamela L. Lutsey, Josef Coresh, Stephen P. Juraschek
Summary: This study compares the long-term clinical consequences of supine hypertension and standing hypotension among middle-aged adults.
Review
Chemistry, Medicinal
Wasim Akram, Mohd Rihan, Sakeel Ahmed, Swamita Arora, Sameer Ahmad, Rahul Vashishth
Summary: Cardiovascular diseases (CVDs) have a significant global impact, and available therapeutic options have side effects. Bioactive compounds from natural sources, particularly the marine ones, have shown promising results in treating CVDs. This review focuses on the cardioprotective potential of marine-derived compounds for hypertension, ischemic heart disease, myocardial infarction, and atherosclerosis. It also discusses the current use, future trajectory, and limitations of marine-derived components.
Review
Cell Biology
Shivan Barungi, Pablo Hernandez-Camarero, Gerardo Moreno-Terribas, Rafael Villalba-Montoro, Juan Antonio Marchal, Elena Lopez-Ruiz, Macarena Peran
Summary: Cardiovascular diseases (CVD) are the leading causes of death and disability in the world, with coronary artery disease (CAD) being the most common form. The complications of atherosclerosis, characterized by the buildup of plaques that restrict and block blood flow, contribute to the development of CAD. Advanced technologies like nanotechnology and vascular tissue engineering show promise in providing efficient and long-lasting therapeutic options for CVD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Utkarsh Bhutani, Tithi Basu, Saptarshi Majumdar
Summary: Oral delivery is a popular method of drug administration, but still has limitations in delivering certain drugs such as anti-cancer drugs and vaccines. To overcome physiological barriers, modern designs including 3D printing devices and formulations are used to achieve sustained delivery. Pharmaceutical organizations are also making significant progress towards commercializing long-acting vehicles in this field.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Ghulam Mustafa, Dilawar Hassan, Mahira Zeeshan, Gustavo Ruiz-Pulido, Narges Ebrahimi, Aisha Mobashar, Mehrab Pourmadadi, Abbas Rahdar, Saman Sargazi, Sonia Fathi-karkan, Dora I. Medina, Ana M. Diez-Pascual
Summary: Huntington's disease is a neurological disorder characterized by a reduction in specific neurons in the brain. Stem cell therapy and nanotechnology have shown great potential in treating this disease, with stem cells being able to differentiate into various cells and nanotechnology providing targeted drug delivery. This review discusses the different types of nanoparticles and their application in the treatment of Huntington's disease.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Zhaoyue Lv, Yi Zhu, Feng Li
Summary: DNA nanomaterials, with unique properties such as biocompatibility and precise control, have shown significant advantages as delivery vectors for nucleic acid-based drugs. This study summarizes the recent progress in the design of DNA-based nanomaterials for cancer therapy, showcasing their applications in controlled nucleic acid delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Engineering, Biomedical
Luise Tomasetti, Miriam Breunig
ADVANCED HEALTHCARE MATERIALS
(2018)
Article
Chemistry, Multidisciplinary
Andrea E. Dillinger, Michaela Guter, Franziska Froemel, Gregor R. Weber, Kristin Perkumas, W. Daniel Stamer, Andreas Ohlmann, Rudolf Fuchshofer, Miriam Breunig
Review
Pharmacology & Pharmacy
Raphael Mietzner, Miriam Breunig
DRUG DISCOVERY TODAY
(2019)
Article
Chemistry, Medicinal
Stefanie Thalhauser, David Peterhoff, Ralf Wagner, Miriam Breunig
JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Meeting Abstract
Ophthalmology
Tobias Sonntag, Franziska Froemel, Michaela Guter, Andrea Dillinger, Rudolph Fuchshofer, Miriam Breunig
ACTA OPHTHALMOLOGICA
(2019)
Meeting Abstract
Ophthalmology
Raphael Mietzner, Christian Kade, Franziska Froemel, Rudolf Fuchshofer, Joachim Wegener, Miriam Breunig
ACTA OPHTHALMOLOGICA
(2019)
Review
Chemistry, Multidisciplinary
Stefanie Thalhauser, David Peterhoff, Ralf Wagner, Miriam Breunig
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Pharmacology & Pharmacy
Raphael Mietzner, Christian Kade, Franziska Froemel, Diana Pauly, W. Daniel Stamer, Andreas Ohlmann, Joachim Wegener, Rudolf Fuchshofer, Miriam Breunig
Article
Pharmacology & Pharmacy
Stefanie Thalhauser, Miriam Breunig
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Tobias Sonntag, Franziska Froemel, W. Daniel Stamer, Andreas Ohlmann, Rudolf Fuchshofer, Miriam Breunig
Summary: Nanoparticles (NPs) offer a favorable tool for delivering drugs to the outflow tissues in glaucoma therapy, with differences observed in distribution and stability between bare gold NPs and HA-coated AuNPs. NPs with a diameter of 120 nm showed the highest accumulation in the trabecular meshwork, with exceptionally low gold content in off-target tissues in the anterior chamber.
Article
Immunology
David Peterhoff, Stefanie Thalhauser, Jan M. Sobczak, Mona O. Mohsen, Christoph Voigt, Nicole Seifert, Patrick Neckermann, Alexandra Hauser, Song Ding, Quentin Sattentau, Martin F. Bachmann, Miriam Breunig, Ralf Wagner
Summary: Delivery of HIV-1 envelope (Env) trimer-based immunogens on nanoparticles can enhance immunogenicity and induce a potent, durable and broad neutralizing antibody response. Covalent conjugation of Env to silica nanoparticles (SiNPs) of different sizes shows high stability and improved uptake by dendritic cells. Multivalent Env displayed efficient activation of B cells even at low concentrations, and antibody responses to Env coupled with nanoparticles were stronger in mice compared to free protein.
Article
Chemistry, Medicinal
Raphael Mietzner, Ramona Pawlak, Ernst R. Tamm, Achim Goepferich, Rudolf Fuchshofer, Miriam Breunig
Summary: The loss of Schlemm's canal cell function may be the main cause of primary open-angle glaucoma, and Angpt-1 mimetic nanoparticles could potentially serve as a therapeutic option for restoring this function.
Article
Pharmacology & Pharmacy
Stefanie Thalhauser, David Peterhoff, Ralf Wagner, Miriam Breunig
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2020)
Meeting Abstract
Ophthalmology
Rudolf Fuchshofer, Andrea E. Dillinger, Michaela Anna Guter, Franziska Scherl, Kristin Marie Perkumas, W. Daniel Stamer, Miriam Breunig
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2018)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)