CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication

Rapid viral rebound after analytical treatment interruption in patients with very small HIV reservoir and minimal on‐going viral transcription

(2020) Pieter Pannus et al.   Journal of the International AIDS Society

Improved Prediction of MHC II Antigen Presentation through Integration and Motif Deconvolution of Mass Spectrometry MHC Eluted Ligand Data

(2020) Birkir Reynisson et al.   JOURNAL OF PROTEOME RESEARCH

HIV-Resistant and HIV-Specific CAR-Modified CD4+ T Cells Mitigate HIV Disease Progression and Confer CD4+ T Cell Help In Vivo

(2020) Colby R. Maldini et al.   MOLECULAR THERAPY

Challenges and Opportunities of Using Adoptive T-Cell Therapy as Part of an HIV Cure Strategy

(2020) Yuqi Zhou et al.   JOURNAL OF INFECTIOUS DISEASES

Diversifying the structure of zinc finger nucleases for high-precision genome editing

(2019) David E. Paschon et al.   Nature Communications

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

(2019) Ravindra K. Gupta et al.   NATURE

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

(2019) Katherine M. Bruner et al.   NATURE

Non-viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient In Vivo Genome Editing of Multiple Therapeutic Gene Targets

(2019) Anthony Conway et al.   MOLECULAR THERAPY

Predictions of time to HIV viral rebound following ART suspension that incorporate personal biomarkers

(2019) Jessica M. Conway et al.   PLoS Computational Biology

CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia

(2019) Lei Xu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neoantigen Dissimilarity to the Self-Proteome Predicts Immunogenicity and Response to Immune Checkpoint Blockade

(2019) Lee P. Richman et al.   Cell Systems

HIV-1 latent reservoir size and diversity are stable following brief treatment interruption

(2018) D. Brenda Salantes et al.   JOURNAL OF CLINICAL INVESTIGATION

MHCflurry: Open-Source Class I MHC Binding Affinity Prediction

(2018) Timothy J. O'Donnell et al.   Cell Systems

The Control of HIV after Antiretroviral Medication Pause (CHAMP) study: post-treatment controllers identified from 14 clinical studies

(2018) Golnaz Namazi et al.   JOURNAL OF INFECTIOUS DISEASES

Differential Pathogen-Specific Immune Reconstitution in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Children

(2018) Maximilian Muenchhoff et al.   JOURNAL OF INFECTIOUS DISEASES

Cell-Mediated Immunity to Target the Persistent Human Immunodeficiency Virus Reservoir

(2017) James L. Riley et al.   JOURNAL OF INFECTIOUS DISEASES

Genome editing of the HIV co-receptors CCR5 and CXCR4 by CRISPR-Cas9 protects CD4+ T cells from HIV-1 infection

(2017) Zhepeng Liu et al.   Cell and Bioscience

Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor

(2017) Rachel S. Leibman et al.   PLoS Pathogens

The clinical applications of genome editing in HIV

(2016) Cathy X. Wang et al.   BLOOD

Which therapeutic strategy will achieve a cure for HIV-1?

(2016) Anthony R Cillo et al.   Current Opinion in Virology

Preclinical development and qualification of ZFN-mediated CCR5 disruption in human hematopoietic stem/progenitor cells

(2016) David L DiGiusto et al.   Molecular Therapy-Methods & Clinical Development

Gapped sequence alignment using artificial neural networks: application to the MHC class I system

(2015) Massimo Andreatta et al.   BIOINFORMATICS

Restoration of CD4+Responses to Copathogens in HIV-Infected Individuals on Antiretroviral Therapy Is Dependent on T Cell Memory Phenotype

(2015) Catherine Riou et al.   JOURNAL OF IMMUNOLOGY

CCR5-Δ32 Heterozygosity, HIV-1 Reservoir Size, and Lymphocyte Activation in Individuals Receiving Long-term Suppressive Antiretroviral Therapy

(2015) Timothy J. Henrich et al.   JOURNAL OF INFECTIOUS DISEASES

Therapeutic Vaccination With Dendritic Cells Loaded With Autologous HIV Type 1–Infected Apoptotic Cells

(2015) Bernard J. C. Macatangay et al.   JOURNAL OF INFECTIOUS DISEASES

Engineering T Cells to Functionally Cure HIV-1 Infection

(2015) Rachel S Leibman et al.   MOLECULAR THERAPY

HIV reservoirs as obstacles and opportunities for an HIV cure

(2015) Tae-Wook Chun et al.   NATURE IMMUNOLOGY

CCR5 Δ32 homozygous cord blood allogeneic transplantation in a patient with HIV: a case report

(2015) Rafael F Duarte et al.   Lancet HIV

Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

(2014) Pablo Tebas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Incomplete Recovery of Pneumococcal CD4 T Cell Immunity after Initiation of Antiretroviral Therapy in HIV-Infected Malawian Adults

(2014) Enoch Sepako et al.   PLoS One

Efficient Clinical Scale Gene Modification via Zinc Finger Nuclease–Targeted Disruption of the HIV Co-receptor CCR5

(2013) Dawn A. Maier et al.   HUMAN GENE THERAPY

CD4+T-cell depletion in HIV infection: mechanisms of immunological failure

(2013) Afam A. Okoye et al.   IMMUNOLOGICAL REVIEWS

Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV

(2012) P. Tebas et al.   BLOOD

HIV and HLA Class I: An Evolving Relationship

(2012) Philip J.R. Goulder et al.   IMMUNITY

Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

(2012) J. Scholler et al.   Science Translational Medicine

The Toll-Like Receptor Gene Family Is Integrated into Human DNA Damage and p53 Networks

(2011) Daniel Menendez et al.   PLoS Genetics

AIDS Clinical Trials Group 5197: A Placebo‐Controlled Trial of Immunization of HIV‐1–Infected Persons with a Replication‐Deficient Adenovirus Type 5 Vaccine Expressing the HIV‐1 Core Protein

(2010) Robert T. Schooley et al.   JOURNAL OF INFECTIOUS DISEASES

Transient cold shock enhances zinc-finger nuclease–mediated gene disruption

(2010) Yannick Doyon et al.   NATURE METHODS

Antiretroviral therapy in acute and recent HIV infection: a prospective multicenter stratified trial of intentionally interrupted treatment

(2009) Paul Volberding et al.   AIDS

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Emerging Concepts in the Immunopathogenesis of AIDS

(2008) Daniel C. Douek et al.   Annual Review of Medicine

Activation of a dendritic cell–T cell axis by Ad5 immune complexes creates an improved environment for replication of HIV in T cells

(2008) Matthieu Perreau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

(2008) Elena E Perez et al.   NATURE BIOTECHNOLOGY