Article
Endocrinology & Metabolism
Yi Zhong, Ting-Ting Lu, Xiao-Mei Liu, Bing-Li Liu, Yun Hu, Shu Liu, Jie Wang, Guo-Qing Li, Xiao-Ming Mao
Summary: The dysfunction of Tregs in GD patients might be caused by the downregulation of PD-1 expression in Tregs induced by high levels of serum T3.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Sohini Banerjee, Uma Nahar, Divya Dahiya, Soham Mukherjee, Pranab Dey, Rijuneeta Gupta, Bishan Radotra, Naresh Sachdeva, Ashwani Sood, Sanjay Kumar Bhadada, Anil Bhansali
Summary: This study aimed to define the tumor microenvironment (TME) of papillary thyroid carcinomas (PTCs) by characterizing the tumor-infiltrating lymphocytes (TILs). The results showed a high presence of CD8(+) cytotoxic T lymphocytes (CTLs) and FoxP3(+) T regulatory cells (Tregs) in PTC cases with lymphocytic thyroiditis (LT). Flow cytometry and immunohistochemistry analysis revealed an association between PD-1/PD-L1 expression and lymph node metastasis and the presence of Treg cells.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Shubai Zhong, Yuanqin Yin
Summary: Sepsis is a severe syndrome with high incidence and mortality that occurs when the immune system overreacts to an infection, leading to multiple organ dysfunction. Immunosuppression plays a crucial role in the clinical treatment and prognosis of sepsis. Recent studies have highlighted the involvement of the programmed cell death 1 signaling pathway in the development of immunosuppression in sepsis. This review systematically presents the mechanisms of immune dysregulation in sepsis, discusses the expression and regulatory effects of the programmed cell death 1 signaling pathway on immune cells associated with sepsis, and explores the current research developments and prospects for using this pathway in immunomodulatory therapy for sepsis. The review also identifies remaining questions and future research directions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Soumi Sadhu, Sanjay Kumar, Dipendra Kumar Mitra, Beenu Joshi
Summary: Pathogen detection is the most important stage in activating an appropriate immune response during an infection. In leprosy patients, the expression patterns of TLR2 and TLR4 are associated with the immunosuppressive markers PD-1 and PD-L1, and blocking the interaction of PD-1 and PD-L1 can improve immune activation status.
Article
Medicine, General & Internal
Chunyi Shen, Zhen Zhang, Yonggui Tian, Feng Li, Lingxiao Zhou, Wenyi Jiang, Li Yang, Bin Zhang, Liping Wang, Yi Zhang
Summary: The study demonstrated that combining SFN with CAR-T cells enhanced cytotoxicity and antitumor functions by modulating the PD-1/PD-L1 pathway, suggesting a promising strategy for cancer immunotherapy.
Article
Immunology
Xinxiu Lin, Zhijing Li, Guangshun Gong, Huan Wang, Xuhui Fang, Gil Mor, Aihua Liao
Summary: This review discusses the role of PD-1 in memory T cell differentiation and function, as well as its potential mechanisms in tumor immunotherapy and immune diseases.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Natasa Kustrimovic, Daniela Gallo, Eliana Piantanida, Luigi Bartalena, Adriana Lai, Nicola Zerbinati, Maria Laura Tanda, Lorenzo Mortara
Summary: Maintaining the delicate balance between immune response and tolerance is crucial for health. T regulatory cells play a pivotal role in preserving self-tolerance and suppressing inflammation. In Graves' disease, these cells are likely impaired or reduced in frequency. Understanding the role of Tregs in Graves' disease is important for developing new treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Na Gao, Taoao Li, Wei Cui, Limin Zhao, Jianghui Zhang, Lili Pan
Summary: The study investigates abnormal expressions of PD-1 in patients with TAK. PD-1 expression was analyzed by flow cytometry and serum cytokines IL-10, IL-7, IL-2, IL-15, CCL2, CCL3, and CXCL10 were detected. The results show that the mean fluorescence intensity of PD-1 in CD4(+)PD-1(+) cells as well as the frequency of CD4(+)Foxp3(-)PD-1(+) cells were decreased in TAK patients compared to healthy controls.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2023)
Review
Endocrinology & Metabolism
Yuta Tanizaki, Yuki Shibata, Wonho Na, Yun-Bo Shi
Summary: Amphibian metamorphosis, especially in anurans like Xenopus laevis and Xenopus tropicalis, is a valuable model to study how T3 regulates adult organ development due to its similarity to mammalian postembryonic development and its independence from maternal influence. Studies on intestinal remodeling have provided important insights into the molecular mechanisms of T3 regulation of cell fate during development, suggesting that T3-induced activation of the cell cycle program is crucial for larval epithelial cell death and the formation of adult intestinal stem cells.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eduardo Valli, Tomas Dalotto-Moreno, Helena A. Sterle, Santiago P. Mendez-Huergo, Maria A. Paulazo, Silvia I. Garcia, Carlos J. Pirola, Alicia J. Klecha, Gabriel A. Rabinovich, Graciela A. Cremaschi
Summary: Hypothyroidism affects immunity and the role of the HPT axis in immunoregulation is not well understood. This study investigated the regulatory role of HPT axis components in hypothyroid-related immunosuppression. Tg-Trh mice showed increased T-cell proliferation and Th1 cytokine release. Hypothyroid mice had increased frequency of regulatory T cells (Tregs), while Tg-Trh mice did not. Galectin-1 (Gal-1), expressed by Tregs, was found to be involved in immunosuppression in hypothyroid conditions.
Article
Oncology
Julie Niogret, Helene Berger, Cedric Rebe, Romain Mary, Elise Ballot, Caroline Truntzer, Marion Thibaudin, Valentin Derangere, Christophe Hibos, Lea Hampe, David Rageot, Theo Accogli, Philippe Joubert, Bertrand Routy, James Harker, Frederique Vegran, Francois Ghiringhelli, Fanny Chalmin
Summary: Tfh cells play an important role in antitumor immune response, especially in a CD8(+)-dependent manner, by producing interleukin-21 to support the function of exhausted T cells. Their accumulation in tumor sites and draining lymph nodes is closely associated with treatment efficacy and patient survival.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Mizuki Sekino, Manabu Iwadate, Yukie Yamaya, Yoshiko Matsumoto, Satoshi Suzuki, Hiroshi Mizunuma, Keiichi Nakano, Izumi Nakamura, Shinichi Suzuki
Summary: PD-L1 expression is associated with clinicopathological factors and prognosis in thyroid cancer, suggesting the potential efficacy of immune checkpoint inhibitors. This study aims to characterize PD-L1 expression, BRAF(V600E) mutation, and cellular and humoral immunity in thyroid cancer, and investigate predictors of anti-PD-L1 antibody therapy effectiveness. The findings suggest that PD-L1 expression is significantly correlated with BRAF(V600E) mutation and CD8+ expression, and can serve as a prognostic indicator for survival in patients with thyroid cancer.
Article
Oncology
Federica Liotti, Narender Kumar, Nella Prevete, Maria Marotta, Daniela Sorriento, Caterina Ierano, Andrea Ronchi, Federica Zito Marino, Sonia Moretti, Renato Colella, Efiso Puxeddu, Simona Paladino, Yoshihito Kano, Michael Ohh, Stefania Scala, Rosa Marina Melillo
Summary: In thyroid cancer, PD-1 expression in epithelial cells is associated with tumor stage and lymph-node metastasis. Overexpressing/stimulating PD-1 promotes TC cell proliferation and migration, while inhibiting PD-1 has the opposite effect. PD-1 blockade not only restores anti-cancer immunity but also directly impairs TC cell growth by inhibiting the SHP2/Ras/MAPK signaling pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Neurosciences
HaiXia Li, Chao Zheng, Jinming Han, Jie Zhu, Shan Liu, Tao Jin
Summary: The PD-1/PD-L1 axis plays a crucial role in multiple sclerosis (MS), and understanding the complex relationship between them may expand our knowledge of therapeutic approaches.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Xuewei Luo, Guicheng Du, Yufei Long, Mengchao Zheng, Bingye Chen, Weiting Li, Guoliang Yan, Zhongquan Qi, Tianshu Lan
Summary: This study aims to investigate whether DC-derived exosomes (DEX) containing donor antigens (H2b) and high levels of PD-L1 expression can suppress graft rejection. It is demonstrated that DEXPDL1+ can present donor antigens and PD-L1 co-inhibitory signals to H2b-reactive T cells, prolonging the survival of heart grafts from B6 (H2b) mice. Furthermore, DEXPDL1+ treatment provides a new vehicle for presenting co-inhibitory signals to donor-specific T cells.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
F. Y. Han, Q. Shi, C. Zheng, M. Z. Li, H. Feng, C. J. Zhang, S. Z. Zhang, X. Y. Fan, X. F. Niu, J. C. Han, T. Wang
Summary: In this study, a Mg-Zn-Al-Ca alloy was processed using forward extrusion and post ECAP method. The evolution of microstructure and mechanical properties of the alloy was systematically investigated. The results showed that the decreased-temperature ECAP processing led to significant grain refinement and the production of substructures in the alloy. The alloy achieved a minimum average grain size of 1.04 μm after specific passes of ECAP at certain temperatures. Furthermore, the texture type of the alloy changed after ECAP deformation. The Mg-5Zn-2Al-1Ca alloy exhibited excellent mechanical properties after the last passes of ECAP, with strength increase contributed by grain boundary strengthening, texture strengthening, and Orowan strengthening effect.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2023)
Article
Automation & Control Systems
Song Zhang, Jianeng Lin, Yugen You, Ningbo Yu, Jianda Han
Summary: This study proposes a strategy called CorrCA-RFG which uses correlated components analysis and random forest regressor to achieve accurate motion estimation from surface electromyogram (sEMG) signals. The proposed method outperforms three other methods in terms of estimation performance, demonstrating the effectiveness of extracting user-independent sEMG features for robust motion estimation.
MEASUREMENT & CONTROL
(2023)
Article
Materials Science, Multidisciplinary
Yuyang Cao, Shiqiang Wei, Quan Zhou, Pengjun Zhang, Changda Wang, Kefu Zhu, Wenjie Xu, Xin Guo, Xiya Yang, Yixiu Wang, Xiaojun Wu, Shuangming Chen, Li Song
Summary: Transition metal carbides or nitrides, known as MXenes, are promising two-dimensional materials for energy conversion and storage. The surface chemistry of MXenes can be tuned to influence their physicochemical properties. In this study, Ti2NT (x) MXene with -Cl and -O terminations was obtained through copper chloride molten salt etching at a low temperature. The surface terminations were found to affect the lithium-ion storage performance.
Article
Clinical Neurology
Xin Qiu, Yalun Dai, Si Cheng, Hong-Qiu Gu, Yong Jiang, Xia Meng, Yilong Wang, Xingquan Zhao, Yingyu Jiang, Zhe Xu, Xinying Huang, Meng Wang, Tian Jie Lyu, Yubo Wang, Jiaxu Weng, Lingyun Cui, Yi Shangguan, Hao Li, Yongjun Wang, Zixiao Li
Summary: The presence of somatic mutations contributing to clonal haematopoiesis of indeterminate potential (CHIP) is associated with a higher risk of recurrent stroke, recurrent ischaemic stroke, and combined vascular events in patients who had their first-ever acute ischaemic stroke. Hyperinflammation may play an important role in the relationship between CHIP and recurrent stroke.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jingjing Liu, Yuduo Wu, Hairui Sun, Xiaowei Liu, Xiaoyan Gu, Ye Zhang, Ying Zhao, Jiancheng Han, Yihua He
Summary: This study investigated the association between prenatal placental DNA methylation and congenital heart disease (CHD). Through differential methylation analysis, several genes and pathways related to heart development and disease were identified. These findings suggest that placental tissue's DNA methylation level is closely associated with fetal CHD.
MOLECULAR GENETICS AND GENOMICS
(2023)
Article
Robotics
Xiangdong Meng, Haoyang Xi, Jinghe Wei, Yuqing He, Jianda Han, Aiguo Song
Summary: This paper proposes a novel concept of contact-based landing on a mobile platform and designs an adaptive backstepping controller. Flight experiments and simulated scenarios are conducted to evaluate the feasibility of the proposed landing scheme and control strategy. Furthermore, vision-based recognition and localization methods are studied to enhance system autonomy.
Article
Obstetrics & Gynecology
Jian Zhuo, Yanchun Zhao, Jianjun Han, He Li, Ruiying Hao, Yan Yang, Luxian Dai, Ankang Sheng, Xiaohong Yang, Weiguang Liu
Summary: The expression of Rab10 in breast cancer is closely related to prognosis, indicating that it can be used as an effective clinical prognostic biomarker.
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
(2023)
Article
Chemistry, Physical
Shouzhen Cao, Zongze Li, Jiafei Pu, Jianchao Han, Qi Dong, Mingdong Zhu
Summary: TiAl alloys are high-temperature structural materials. The Ti-46Al-8Nb-2.5V alloy exhibited phase transformations and texture evolution during hot compression and subsequent annealing at 900 degrees C. The volume fraction of the alpha(2) phase decreased, and the gamma -> alpha(2) phase transformation occurred during annealing.
Article
Multidisciplinary Sciences
Jian Zhuo, Jianjun Han, Yanchun Zhao, Ruiying Hao, Chong Shen, He Li, Luxian Dai, Ankang Sheng, Hanyu Yao, Xiaohong Yang, Weiguang Liu
Summary: The study provides insights into the role of RAB10 in breast cancer, showing its association with prognosis and its impact on cell proliferation, invasion, and immune cell infiltration. RAB10 may serve as a potential biomarker or molecular target for breast cancer.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Zhengyan Zhang, Erli Lyu, Zhe Min, Ang Zhang, Yue Yu, Max Q. -H. Meng
Summary: This paper proposes a semi-supervised point cloud registration method, which extracts features using a modified autoencoder, treats point clouds as probability distributions, and estimates correspondences using an augmented regression network. Extensive experiments validate the superior performance of the proposed method compared to other methods.
Article
Chemistry, Multidisciplinary
Boshi Tian, Ruixue Tian, Shaohua Liu, Yan Wang, Shili Gai, Ying Xie, Dan Yang, Fei He, Piaoping Yang, Jun Lin
Summary: This study constructed a biodegradable, porous Mn-doped ZnO nanocluster with enhanced piezoelectric effect through doping engineering, which has the potential application in inhibiting cancer cell growth and inducing ferroptosis. The results showed that lattice distortion and oxygen vacancy generation induced by Mn-doping play important roles in improving the catalytic efficiency.
ADVANCED MATERIALS
(2023)
Article
Physics, Nuclear
Xiang Chen, Li Li, Ying Cui, Junping Yang, Zhuxia Li, Yingxun Zhang
Summary: This study extends a method for reconstructing the impact parameter distributions in heavy ion collisions by using the Bayesian method and K-means clustering method. The reconstructed distributions provide insights into the correlation between multiplicity and transverse momentum at different centralities.
Article
Cardiac & Cardiovascular Systems
Xiaoxue Zhou, Tingyang Yang, Ye Zhang, Yanping Ruan, Jiancheng Han, Xiaowei Liu, Ying Zhao, Xiaoyan Gu, Tingting Liu, Hairui Wang, Yihua He
Summary: This study analyzed the quantitative data obtained from fetal echocardiography to achieve prenatal diagnosis of atrioventricular septal defects (AVSDs). Six variables obtained on the four-chamber view were found to have high diagnostic value, with atrial to ventricular length ratio in end-diastole (AVLR-ED) and its Q score being the most convenient and accurate.
CONGENITAL HEART DISEASE
(2023)
Article
Materials Science, Multidisciplinary
Wang Hao, Gao Tianbao, Wei Junxin, Zhang Mengfei, Deng Ruijun, Jia Yi, Han Jianchao
Summary: Ti-6Al-4V/Ti-43Al-3V-2Cr composite clad plate without interfacial defects was successfully prepared by a high-reduction hot-rolling method, and the microstructure and mechanical properties were studied. The experimental results show that the composite plate has good interfacial quality and mechanical properties.
RARE METAL MATERIALS AND ENGINEERING
(2023)
Article
Orthopedics
Qian Fang, Jianguo Han, Wenzheng Liu, Dong Wang, Zilu Ge, Guanglin Wang
Summary: A reliable predictive nomogram was developed for failed correction of intertrochanteric fractures due to cut-out of the proximal femur nail anti-rotation (PFNA) device. The nomogram was based on independent predictors including body mass index (BMI), quality of reduction, blade position, and tip-apex distance (TAD).
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
