Article
Medicine, General & Internal
Jian Yang, Xiaoyan He, Li Qian, Binbin Zhao, Yajuan Fan, Fengjie Gao, Bin Yan, Feng Zhu, Xiancang Ma
Summary: This study investigated the causal effects of plasma proteome on ASD, ADHD, and TS using the two-sample Mendelian Randomization approach. The findings indicate that increased levels of MAPKAPK3 and MRPL33 are associated with a higher risk of ASD, while increased MANBA levels are associated with a lower risk of ADHD. These causal associations were robust in sensitivity analysis, suggesting the involvement of the MAPK/ERK signaling pathway and mitochondrial dysfunction in the pathogenesis of ASD, and a role of beta-mannosidase deficiency in the development of ADHD.
Article
Psychology, Biological
Agnieszka Gidziela, Yasmin I. I. Ahmadzadeh, Giorgia Michelini, Andrea G. G. Allegrini, Jessica Agnew-Blais, Lok Yan Lau, Megan Duret, Francesca Procopio, Emily Daly, Angelica Ronald, Kaili Rimfeld, Margherita Malanchini
Summary: This meta-analysis examines the association between genetic variation and neurodevelopmental disorders (NDDs), as well as their overlap and co-occurrence with disruptive, impulse control, and conduct disorders (DICCs). The results show that NDDs are substantially heritable and have moderate genetic correlations between each other. Additionally, there is a strong genetic overlap between NDDs and DICCs. The findings have implications for clinical and educational diagnostic procedures and highlight the need for more balanced research in developmental genetics.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Psychiatry
Ebba Du Rietz, Erik Pettersson, Isabell Brikell, Laura Ghirardi, Qi Chen, Catharina Hartman, Paul Lichtenstein, Henrik Larsson, Ralf Kuja-Halkola
Summary: ADHD shows strong genetic associations with neurodevelopmental disorders, and its comorbidity is largely explained by genetically influenced general psychopathology. The link between ADHD and externalising or internalising disorders is weaker and influenced by non-shared environmental effects.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Psychology, Multidisciplinary
Yiwei Yang, Shi Zhao, Meihui Zhang, Mi Xiang, Jian Zhao, Shucheng Chen, Hui Wang, Lefei Han, Jinjun Ran
Summary: Based on the data from the National Health Interview Survey, we estimated the prevalence of attention-deficit/hyperactivity disorder, autism spectrum disorder, intellectual disorder, and learning disability among US children and adolescents aged 3-17 years in 2019 and 2020. The study found that the prevalence of these neurodevelopmental disorders varied by demographics, comorbidity/mental problems, household/parental characteristics, and stressful life events.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Clinical Neurology
Eliza Honybun, Rebecca Thwaites, Charles B. Malpas, Genevieve Rayner, Alison Anderson, Janet Graham, Alison Hitchcock, Terence J. O'Brien, Frank J. E. Vajda, Piero Perucca
Summary: In this study, prenatal exposure to VPA was found to offset the usual male sex-related predominance in the incidence of ASD. Males exposed to other AEDs had higher ASD symptoms, while this typical sex dynamic was not evident in VPA-exposed children. No dose-response relationship was found between VPA exposure and ASD symptoms.
Article
Psychiatry
Camille Hours, Christophe Recasens, Jean-Marc Baleyte
Summary: According to scientific literature, a high percentage of individuals with autism spectrum disorder (ASD) also have comorbid attention deficit hyperactivity disorder (ADHD). The significance of this dual diagnosis and its relationship to attentional impairment in ASD patients are subjects of debate in the neurobiological field.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Grace Mengqin Ge, Edmund C. L. Cheung, Kenneth K. C. Man, Patrick Ip, Wing Cheong Leung, Gloria H. Y. Li, Annie W. C. Kung, Ching-Lung Cheung, Ian C. K. Wong
Summary: The study found that maternal levothyroxine treatment during pregnancy is associated with an increased risk of preterm birth in offspring, but not significantly associated with low birth weight, ADHD, or ASD.
Article
Psychology, Clinical
Chittaranjan Andrade
Summary: Two large cohort studies indicate that gestational exposure to antipsychotic drugs is more likely a marker than a cause of neurodevelopmental disorders in offspring. The risks associated with exposure to these drugs during pregnancy become statistically non-significant after adjusting for confounding factors.
JOURNAL OF CLINICAL PSYCHIATRY
(2022)
Article
Neurosciences
Aaron Barron, Cathal M. McCarthy, Gerard W. O'Keeffe
Summary: Preeclampsia is a common and serious hypertensive disorder of pregnancy, with in utero exposure potentially acting as an environmental risk factor for various neurodevelopmental disorders. The mechanisms are uncertain, but inflammation and oxidative stress likely play a major role in mediating this association.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ignazio Stefano Piras, Stefano Gabriele, Laura Altieri, Federica Lombardi, Roberto Sacco, Carla Lintas, Barbara Manzi, Paolo Curatolo, Maria Nobile, Catia Rigoletto, Massimo Molteni, Antonio M. Persico
Summary: The research indicates that serum arylesterase activity is reduced in children and adolescents with ADHD, which may be related to increased oxidative stress rather than specific genetic factors.
Article
Multidisciplinary Sciences
Xuemei Jin, Huilin Zhu, Wei Cao, Xiaobing Zou, Jiajia Chen
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting 2% of children. A computer vision-based motion trajectory detection approach was proposed in this study to objectively extract movement features (MFs) from videos and evaluate children's activity levels in ASD assessment. The most relevant MFs were found to be the pixel distance (PD)-based MFs of all three body key points and the instantaneous pixel velocity (IPV)-based MFs of the right wrist key point in Table-play activity, which can be used as an auxiliary means for automating the evaluation of activity levels in ASD assessment.
SCIENTIFIC REPORTS
(2023)
Review
Nutrition & Dietetics
Emma Derbyshire, Michael Maes
Summary: Neurodevelopmental disorders are increasing in prevalence, possibly due to deficits in choline intake during critical periods of neurodevelopment. Choline is a crucial micronutrient for optimal brain functioning and neurodevelopment. Research has shown low choline intakes and altered choline status in various population subgroups, including pregnant women, children with autism spectrum disorders, individuals with attention deficit hyperactivity disorder, and those with dyslexia. Optimal choline provision may offer neuronal protection in early life and mitigate cognitive effects associated with neurodevelopmental conditions.
Article
Medicine, General & Internal
Shuyun Chen, Mengyu Fan, Brian K. Lee, Christina Dalman, Hakan Karlsson, Renee M. Gardner
Summary: This study investigated the associations between gestational weight gain (GWG) and risks of neurodevelopmental disorders (NDDs) in offspring, specifically autism spectrum disorder (ASD), intellectual disability (ID), and attention deficit/hyperactivity disorder (ADHD). The findings suggest that the timing and rate of weight gain during pregnancy have different effects on the risk of NDDs in children.
Article
Psychology, Developmental
Kate Stephens, Timothy J. Silk, Vicki Anderson, Philip Hazell, Peter G. Enticott, Emma Sciberras
Summary: Children with ADHD combined with ASD symptoms show poorer social and emotional functioning compared to those with ADHD alone. A study found significant associations between white matter microstructure, specifically the left cingulum, and emotional problems in the ADHD + ASD group. These results provide insights into the specific biological basis of emotional problems in children with ADHD and ASD symptoms.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Christoph Buehrer, Stefanie Endesfelder, Till Scheuer, Thomas Schmitz
Summary: Paracetamol, commonly used during pregnancy for fever and pain, is suspected to increase the risk of attention deficit hyperactivity disorder and autism spectrum disorder in offspring by about 25% according to epidemiological studies. However, there are still unknown factors and mechanisms that require further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychology, Developmental
Pedro Fonseca Zuccolo, Caio Borba Casella, Daniel Fatori, Elizabeth Shephard, Luisa Sugaya, Wagner Gurgel, Luis Carlos Farhat, Adriana Argeu, Monike Teixeira, Luara Otoch, Guilherme Polanczyk
Summary: This study examined emotional problems in children and adolescents in Brazil during the COVID-19 pandemic. The results showed fluctuations in anxiety and depressive symptoms during one year follow-up, associated with periods of social mobility and mortality. Older age, feeling lonely, previous diagnosis of mental or neurodevelopmental disorder, previous exposure to traumatic events or psychological aggression, parental psychopathology, and sleeping less than 8 hours a day were all associated with increased rates of anxiety and depressive symptoms.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Review
Psychiatry
Rebeca Pelosof, Leonardo A. dos Santos, Luis C. Farhat, Wagner F. Gattaz, Leda Talib, Andre R. Brunoni
Summary: This updated review found an increase in BDNF levels after ECT treatment for depression. However, there was significant heterogeneity and limited sample sizes in the studies, indicating the need for further research to investigate factors driving the variability of effects.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychology, Developmental
Luiza K. Axelrud, Mauricio S. Hoffmann, Daniel E. Vosberg, Marcos Santoro, Pedro M. Pan, Ary Gadelha, Sintia Belangero, Euripedes C. Miguel, Jean Shin, Anita Thapar, Jordan W. Smoller, Zdenka Pausova, Luis A. Rohde, Matthew C. Keller, Tomas Paus, Giovanni A. Salum
Summary: This study aimed to investigate the influence of parental genetics on offspring cognition, educational attainment, and psychopathology. The findings suggest that parental genetics influence offspring outcomes through genetic and phenotypic pathways, and multiple mediations may be an effective approach for understanding intergenerational transmission of behavioral traits.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Psychology, Developmental
Alice Stephens, Judith Allardyce, Bryony Weavers, Jessica Lennon, Rhys Bevan Jones, Victoria Powell, Olga Eyre, Robert Potter, Valentina Escott Price, David Osborn, Anita Thapar, Stephan Collishaw, Ajay Thapar, Jon Heron, Frances Rice
Summary: A risk prediction model was developed to successfully discriminate adolescents who developed major depressive disorder (MDD) from those who did not. The model could be further developed into a tool to target individuals for low-intensity, selective preventive intervention.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Developmental Biology
Kyle S. Wiley, Caroline Camilo, Gisele Gouveia, Veronica Euclydes, Catherine Panter-Brick, Alicia Matijasevich, Alexandre Archanjo Ferraro, Lislaine Aparecida Fracolli, Anna Maria Chiesa, Euripedes Constantino Miguel, Guilherme V. Polanczyk, Helena Brentani
Summary: Maternal prenatal psychosocial stress is associated with altered hypothalamic-pituitary-adrenal axis (HPAA) function among infants. This study found that altered DNA methylation, specifically in the oxytocin receptor gene, may contribute to the regulation of HPAA during infancy. Maternal distress and anxiety symptoms were negatively associated with DNA methylation and cortisol levels in infants.
DEVELOPMENTAL PSYCHOBIOLOGY
(2023)
Article
Psychiatry
Amy Shakeshaft, Rachel Blakey, Alex S. F. Kwong, Lucy Riglin, George Davey Smith, Evie Stergiakouli, Kate Tilling, Anita Thapar
Summary: The COVID-19 pandemic had a negative impact on the mental health of individuals with neurodevelopmental disorders, including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). A study using data from the Avon Longitudinal Study of Parents and Children examined the effects of the pandemic on anxiety, depression, and mental wellbeing in adults with NDDs. The study found that individuals with ADHD and ASD had higher rates of depression, anxiety, and poor mental wellbeing compared to those without these disorders. The pandemic had a greater impact on anxiety levels in individuals with ADHD and ASD, while depressive symptoms decreased, particularly in females with ASD. Overall, mental wellbeing decreased for all participants, but to a lesser extent in those with ADHD and females with ASD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Genetics & Heredity
Ditte Demontis, G. Bragi Walters, Georgios Athanasiadis, Raymond Walters, Karen Therrien, Trine Tollerup Nielsen, Leila Farajzadeh, Georgios Voloudakis, Jaroslav Bendl, Biau Zeng, Wen Zhang, Jakob Grove, Thomas D. Als, Jinjie Duan, F. Kyle Satterstrom, Jonas Bybjerg-Grauholm, Marie Baekved-Hansen, Olafur O. Gudmundsson, Sigurdur H. Magnusson, Gisli Baldursson, Katrin Davidsdottir, Gyda S. Haraldsdottir, Esben Agerbo, Gabriel E. Hoffman, Soren Dalsgaard, Joanna Martin, Marta Ribases, Dorret Boomsma, Maria Soler Artigas, Nina Roth Mota, Daniel Howrigan, Sarah E. Medland, Tetyana Zayats, Veera M. Rajagopal, Merete Nordentoft, Ole Mors, David M. Hougaard, Preben Bo Mortensen, Mark J. Daly, Stephen Faraone, Hreinn Stefansson, Panos Roussos, Barbara Franke, Thomas Werge, Benjamin M. Neale, Kari Stefansson, Anders D. Borglum
Summary: This study conducted a meta-analysis of genome-wide association studies on ADHD and identified 27 significant genetic loci associated with ADHD. They also found that these loci were enriched with genes involved in early brain development. Moreover, they discovered an increased load of rare protein-truncating variants in ADHD, implicating SORCS3 as a potential gene involved in ADHD.
Article
Pediatrics
Moises de Freitas Laurentino, Livia Lindoso, Camilla Astley, Sofia Simao Martins Lavorato, Bianca Pires Ihara, Dandara Carvalho Casado de Lima, Bruno Gualano, Ligia Bruni Queiroz, Rosa Maria Rodrigues Pereira, Guilherme Vanoni Polanczyk, Olavo Pires de Camargo, Clovis Artur Silva, Patricia Moreno Grangeiro
Summary: This study aimed to assess physical and mental health, and health-related quality of life parameters in adolescents with physical disabilities compared to adolescents without disabilities during the COVID-19 pandemic. The results showed that adolescents with disabilities had lower emotional and prosocial problems, lower global function, higher happiness scores, more physical activity, and less screen time compared to controls. This suggests that attending a sports NGO has a positive impact on reducing adverse health indicators for adolescents with disabilities.
REVISTA PAULISTA DE PEDIATRIA
(2023)
Article
Biochemistry & Molecular Biology
Banny Silva Barbosa Correia, Joao Guilherme de Moraes Pontes, Joao Victor Silva Nani, Fabian Villalta, Natalia Cristina Mor, Daniela Bordini, Decio Brunoni, Helena Brentani, Jair Jesus Mari, Mirian A. F. Hayashi, Ljubica Tasic
Summary: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by impaired social communication, interactions, and restricted repetitive behavior. Video modeling for parental training has been proven to be a successful low-cost intervention for children with ASD. Metabolomics and lipidomics analysis using proton NMR spectroscopy showed significant changes in serum metabolites and lipids in ASD children who received parental training, indicating the potential of using these approaches as biomarkers for clinical interventions in ASD.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Psychology, Developmental
P. Santosh, S. Cortese, C. Hollis, S. Bolte, D. Daley, D. Coghill, M. Holtmann, E. J. S. Sonuga-Barke, J. Buitelaar, T. Banaschewski, A. Stringaris, M. Doepfner, S. Van der Oord, S. Carucci, D. Brandeis, P. Nagy, M. Ferrin, D. Baeyens, B. J. van den Hoofdakker, D. Purper-Ouakil, A. Ramos-Quiroga, M. Romanos, C. A. Soutullo, A. Thapar, I. C. K. Wong, A. Zuddas, C. Galera, E. Simonoff
Summary: The COVID-19 pandemic has led to changes in ADHD services, with remote assessments being widely adopted. However, there is a lack of clear guidance on how to conduct these assessments effectively. Therefore, the European ADHD Guidelines Group discusses the strengths and weaknesses of remote assessments and provides recommendations for future studies and clinical practice.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Review
Psychiatry
Luis C. Farhat, Madison Reid, Michael H. Bloch, Emily Olfson
Summary: This study conducted a systematic review and meta-analysis to investigate the epidemiology of excoriation disorder. The pooled prevalence was estimated to be 3.45%, with a higher impact on women compared to men.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Genetics & Heredity
Bethany Vibert, Patricia Segura, Louise Gallagher, Stelios Georgiades, Panagiota Pervanidou, Audrey Thurm, Lindsay Alexander, Evdokia Anagnostou, Yuta Aoki, Catherine S. Birken, Somer L. Bishop, Jessica Boi, Carmela Bravaccio, Helena Brentani, Paola Canevini, Alessandra Carta, Alice Charach, Antonella Costantino, Katherine T. Cost, Elaine A. Cravo, Jennifer Crosbie, Chiara Davico, Federica Donno, Junya Fujino, Alessandra Gabellone, Cristiane T. Geyer, Tomoya Hirota, Stephen Kanne, Makiko Kawashima, Elizabeth Kelley, Hosanna Kim, Young Shin Kim, So Hyun Kim, Daphne J. Korczak, Meng-Chuan Lai, Lucia Margari, Lucia Marzulli, Gabriele Masi, Luigi Mazzone, Jane McGrath, Suneeta Monga, Paola Morosini, Shinichiro Nakajima, Antonio Narzisi, Rob Nicolson, Aki Nikolaidis, Yoshihiro Noda, Kerri Nowell, Miriam Polizzi, Joana Portolese, Maria Pia Riccio, Manabu Saito, Ida Schwartz, Anish K. Simhal, Martina Siracusano, Stefano Sotgiu, Jacob Stroud, Fernando Sumiya, Yoshiyuki Tachibana, Nicole Takahashi, Riina Takahashi, Hiroki Tamon, Raffaella Tancredi, Benedetto Vitiello, Alessandro Zuddas, Bennett Leventhal, Kathleen Merikangas, Michael P. Milham, Adriana Di Martino
Summary: The study examined the impact of the COVID-19 pandemic on youth with autism spectrum disorder and related neurodevelopmental disorders, revealing heterogeneity in symptoms and access to services. The findings can inform recovery efforts and emphasize the importance of international data-sharing and collaborations in addressing the needs of vulnerable populations during crises.
Article
Psychiatry
Amy J. Lynham, Sarah Knott, Jack F. G. Underwood, Leon Hubbard, Sharifah S. Agha, Jonathan I. Bisson, Marianne B. M. van den Bree, Samuel J. R. A. Chawner, Nicholas Craddock, Michael O'Donovan, Ian R. Jones, George Kirov, Kate Langley, Joanna Martin, Frances Rice, Neil P. Roberts, Anita Thapar, Richard Anney, Michael J. Owen, Jeremy Hall, Antonio F. F. Pardinas, James T. R. Walters
Summary: The aim of this study is to develop procedures for curating and aggregating genotypic and phenotypic data in psychiatric research to investigate the relationship between shared symptoms and shared genetic liability. DRAGON-Data is a resource that combines genetic and non-genetic information and can be used for research across traditional psychiatric diagnostic categories.
Review
Multidisciplinary Sciences
Fabio Rosindo Daher de Barros, Caio Novais F. da Silva, Gabriel de Castro Michelassi, Helena Brentani, Fatima L. S. Nunes, Ariane Machado-Lima
Summary: Facial image analysis using image processing and machine learning techniques can help diagnose genetic syndromes and neurodevelopmental disorders. These systems offer faster and cost-effective alternatives for genotyping tests, especially for large-scale applications. However, ensuring the accuracy and reliability of computer-aided diagnosis systems remains a challenge.
