Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide
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Title
Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide
Authors
Keywords
beta cell, diabetes, hyperinsulinemia, insulin resistance, insulin secretion, metabolism, NAFLD, NASH
Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume -, Issue -, Pages 100807
Publisher
Elsevier BV
Online
2021-05-20
DOI
10.1016/j.jbc.2021.100807
References
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Note: Only part of the references are listed.- The GLP-1R agonist liraglutide limits hepatic lipotoxicity and inflammatory response in mice fed a methionine-choline deficient diet
- (2020) Emmanuel Somm et al. Translational Research
- Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells
- (2020) Isabelle Chareyron et al. DIABETOLOGIA
- Liraglutide improves hepatic steatosis and metabolic dysfunctions in a 3-week dietary mouse model of nonalcoholic steatohepatitis
- (2019) Thibaut Duparc et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study
- (2019) Stephen A. Harrison et al. JOURNAL OF HEPATOLOGY
- Pioglitazone improves hepatic mitochondrial function in a mouse model of nonalcoholic steatohepatitis
- (2018) Srilaxmi Kalavalapalli et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Pioglitazone Improved Insulin Sensitivity and First Phase Insulin Secretion Among Obese and Lean People with Diabetes: A Multicenter Clamp Study
- (2018) Xin Qian et al. Diabetes Therapy
- Pioglitazone Improved Insulin Sensitivity and First Phase Insulin Secretion Among Obese and Lean People with Diabetes: A Multicenter Clamp Study
- (2018) Xin Qian et al. Diabetes Therapy
- Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis
- (2017) Kyle S. McCommis et al. HEPATOLOGY
- The effects of liraglutide in mice with diet-induced obesity studied by metabolomics
- (2017) Martina Bugáňová et al. JOURNAL OF ENDOCRINOLOGY
- Thiazolidinediones and Advanced Liver Fibrosis in Nonalcoholic Steatohepatitis
- (2017) Giovanni Musso et al. JAMA Internal Medicine
- Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus
- (2016) Kenneth Cusi et al. ANNALS OF INTERNAL MEDICINE
- Liraglutide Compromises Pancreatic β Cell Function in a Humanized Mouse Model
- (2016) Midhat H. Abdulreda et al. Cell Metabolism
- An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion
- (2016) Kyle S. McCommis et al. Molecular Metabolism
- Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling
- (2015) Kyle S. McCommis et al. Cell Metabolism
- An Insulin-Sensitizing Thiazolidinedione, Which Minimally Activates PPARγ, Does Not Cause Bone Loss
- (2015) Tomohiro Fukunaga et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Protective effects of pioglitazone and/or liraglutide on pancreatic β-cells in db/db mice: Comparison of their effects between in an early and advanced stage of diabetes
- (2015) Tomohiko Kimura et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Pioglitazone Increases Whole Body Insulin Sensitivity in Obese, Insulin-Resistant Rhesus Monkeys
- (2015) Effie Tozzo et al. PLoS One
- Pilot study of liraglutide effects in non-alcoholic steatohepatitis and non-alcoholic fatty liver disease with glucose intolerance in Japanese patients (LEAN-J)
- (2014) Yuichiro Eguchi et al. HEPATOLOGY RESEARCH
- Mitochondrial Metabolism of Pyruvate Is Essential for Regulating Glucose-stimulated Insulin Secretion
- (2014) Jessica N. Patterson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss
- (2014) Anna Secher et al. JOURNAL OF CLINICAL INVESTIGATION
- Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion
- (2014) Patrick A. Vigueira et al. Cell Reports
- Clinical Proof-of-Concept Study With MSDC-0160, a Prototype mTOT-Modulating Insulin Sensitizer
- (2013) J R Colca et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Pioglitazone Acutely Reduces Energy Metabolism and Insulin Secretion in Rats
- (2013) J. Lamontagne et al. DIABETES
- Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains β-Cell Phenotype in Human Islets
- (2013) Nidhi Rohatgi et al. PLoS One
- Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins
- (2013) Jerry R. Colca et al. PLoS One
- Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier
- (2013) A. S. Divakaruni et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
- (2012) Chutima Talchai et al. CELL
- Insulin Resistance and Metabolic Derangements in Obese Mice Are Ameliorated by a Novel Peroxisome Proliferator-activated Receptor γ-sparing Thiazolidinedione
- (2012) Zhouji Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
- (2010) Arun J. Sanyal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pioglitazone Acutely Reduces Insulin Secretion and Causes Metabolic Deceleration of the Pancreatic β-Cell at Submaximal Glucose Concentrations
- (2009) Julien Lamontagne et al. ENDOCRINOLOGY
- Combination of the insulin sensitizer, pioglitazone, and the long-acting GLP-1 human analog, liraglutide, exerts potent synergistic glucose-lowering efficacy in severely diabetic ZDF rats
- (2008) P. J. Larsen et al. DIABETES OBESITY & METABOLISM
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