Short-chain fatty acid butyrate induces IL-10-producing B cells by regulating circadian-clock-related genes to ameliorate Sjögren's syndrome

Gut dysbiosis is prevailing in Sjögren’s syndrome and is related to dry eye severity

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B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids

(2020) Helia N. Sanchez et al.   Nature Communications

Metabolic abnormalities exacerbate Sjögren’s syndrome by and is associated with increased the population of interleukin–17–producing cells in NOD/ShiLtJ mice

(2020) Sun-Hee Hwang et al.   Journal of Translational Medicine

Lactobacillus sakei suppresses collagen-induced arthritis and modulates the differentiation of T helper 17 cells and regulatory B cells

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The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

(2019) Maik Luu et al.   Nature Communications

Butyrate inhibit collagen-induced arthritis via Treg/IL-10/Th17 axis

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Gut Microbiota-Derived Short Chain Fatty Acids Induce Circadian Clock Entrainment in Mouse Peripheral Tissue

(2018) Yu Tahara et al.   Scientific Reports

Circadian Disruption Changes Gut Microbiome Taxa and Functional Gene Composition

(2018) Jessica A. Deaver et al.   Frontiers in Microbiology

IL-10 Producing B Cells Ability to Induce Regulatory T Cells Is Maintained in Rheumatoid Arthritis

(2018) Julie Mielle et al.   Frontiers in Immunology

Attenuation of Rheumatoid Inflammation by Sodium Butyrate Through Reciprocal Targeting of HDAC2 in Osteoclasts and HDAC8 in T Cells

(2018) Da Som Kim et al.   Frontiers in Immunology

Current Insights in Microbiome Shifts in Sjogren’s Syndrome and Possible Therapeutic Interventions

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The Response of IL-17-Producing B Cells to ArtinM Is Independent of Its Interaction with TLR2 and CD14

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Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses

(2017) David Druzd et al.   IMMUNITY

Circadian clock cryptochrome proteins regulate autoimmunity

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Microbial Metabolic Networks at the Mucus Layer Lead to Diet-Independent Butyrate and Vitamin B 12 Production by Intestinal Symbionts

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Lactobacillus reuteri I5007 Modulates Intestinal Host Defense Peptide Expression in the Model of IPEC-J2 Cells and Neonatal Piglets

(2017) Hongbin Liu et al.   Nutrients

The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models

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Gut Microbial Metabolites Fuel Host Antibody Responses

(2016) Myunghoo Kim et al.   Cell Host & Microbe

Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

(2016) Nathan D Mathewson et al.   NATURE IMMUNOLOGY

Clostridium butyricum in combination with specific immunotherapy converts antigen-specific B cells to regulatory B cells in asthmatic patients

(2016) Hong-Ying Liao et al.   Scientific Reports

The Mouse Intestinal Bacterial Collection (miBC) provides host-specific insight into cultured diversity and functional potential of the gut microbiota

(2016) Ilias Lagkouvardos et al.   Nature Microbiology

Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren Syndrome

(2016) Cintia S. de Paiva et al.   Scientific Reports

Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses

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Effects of Diurnal Variation of Gut Microbes and High-Fat Feeding on Host Circadian Clock Function and Metabolism

(2015) Vanessa Leone et al.   Cell Host & Microbe

Specific immunotherapy in combination with Clostridium butyricum inhibits allergic inflammation in the mouse intestine

(2015) Yanhong Shi et al.   Scientific Reports

Lactobacillus rhamnosus GG Protects against Non-Alcoholic Fatty Liver Disease in Mice

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The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Circadian Clock in Oral Health and Diseases

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Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells

(2013) Daniela A Bermejo et al.   NATURE IMMUNOLOGY

B Cells Contribute to Heterogeneity of IL-17 Producing Cells in Rheumatoid Arthritis and Healthy Controls

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TH17 Cell Differentiation Is Regulated by the Circadian Clock

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IL-17A and IL-17F Expression in B Lymphocytes

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NFIL3 Is a Regulator of IL-12 p40 in Macrophages and Mucosal Immunity

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Pathogenic effect of interleukin-17A in induction of Sjögren's syndrome-like disease using adenovirus-mediated gene transfer

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HSG cells, a model in the submandibular clock

(2010) Yoshiaki Onishi   BIOSCIENCE REPORTS

Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex

(2010) Jean-Marc Blouin et al.   INTERNATIONAL JOURNAL OF CANCER

Pathogenetic mechanisms in the initiation and perpetuation of Sjögren's syndrome

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The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals

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