Article
Biochemistry & Molecular Biology
Peter J. O'Dwyer, Robert J. Gray, Keith T. Flaherty, Alice P. Chen, Shuli Li, Victoria Wang, Lisa M. McShane, David R. Patton, James V. Tricoli, P. Mickey Williams, A. John Iafrate, Jeffrey Sklar, Edith P. Mitchell, Naoko Takebe, David J. Sims, Brent Coffey, Tony Fu, Mark Routbort, Larry V. Rubinstein, Richard F. Little, Carlos L. Arteaga, Donna Marinucci, Stanley R. Hamilton, Barbara A. Conley, Lyndsay N. Harris, James H. Doroshow
Summary: The NCI-MATCH trial is a genomically driven, signal-seeking precision medicine platform trial that mainly focuses on patients with treatment-refractory, malignant solid tumors. It is one of the largest tumor-agnostic, precision oncology trials to date, having been launched in 2015 and completed in 2023. A total of nearly 6,000 patients underwent screening and molecular testing, with 1,593 patients being assigned to one of the 38 substudies. Out of the initial 27 substudies, 7 (25.9%) showed positive results, meeting the trial's signal-seeking objective. Key aspects of the trial's design and operational conduct are discussed, highlighting important lessons for future precision medicine studies.
Review
Construction & Building Technology
Mathew Azarian, Asmamaw Tadege Shiferaw, Tor Kristian Stevik, Ola Laedre, Paulos Abebe Wondimu
Summary: The broad and extensive application of public-private partnership (PPP) and its diverse definitions and experiences have led to a lack of clarity and consensus in academia and industry. This paper proposes conducting a comprehensive review to explore the major practice of PPP and provide a broader understanding of this concept based on research since 1979. The findings reveal the dominant application of PPP as a business model in economic and societal practices, with a focus on economic and organizational management and sustainable development.
Editorial Material
Oncology
Yonina R. Murciano-Goroff, Alexander Drilon, Zsofia K. Stadler
Summary: The NCI-MATCH trial, published in the Journal of Clinical Oncology, demonstrates the feasibility of identifying rare and common actionable genetic alterations, highlighting the strength of academic/community partnerships for improving trial access.
Article
Energy & Fuels
Mostafa Kazemi, S. Sepehr Tabatabaei, Niki Moslemi
Summary: This paper presents a new incentive-based approach to increase the penetration of energy storage systems in distribution level. The proposed model is based on a public-private partnership, encouraging private investors to install energy storage systems through increasing the buying price during peak periods and providing discounts during off-peak periods. The study evaluates the applicability of the proposed model using real data and demonstrates the successful partnership between the public and private sectors, resulting in proper peak load shaving and reasonable profits for private households.
JOURNAL OF ENERGY STORAGE
(2023)
Article
Oncology
Kevin Kalinsky, Fangxin Hong, Carolyn K. McCourt, Jasgit C. Sachdev, Edith P. Mitchell, James A. Zwiebel, L. Austin Doyle, Lisa M. McShane, Shuli Li, Robert J. Gray, Larry V. Rubinstein, David Patton, Paul M. Williams, Stanley R. Hamilton, Barbara A. Conley, Peter J. O'Dwyer, Lyndsay N. Harris, Carlos L. Arteaga, Alice P. Chen, Keith T. Flaherty
Summary: This study demonstrates that a clinically significant objective response rate was achieved in patients with an AKT1 E17K-mutated tumor treated with the pan-AKT inhibitor capivasertib, including one complete response.
Article
Multidisciplinary Sciences
Nuno Jose Pinho Rodrigues, Joao M. S. Carvalho
Summary: This study analyzed the economic and financial results of the PPP model compared to the PMH model in Portugal. The findings showed that the PPP model had advantages in terms of economic and financial results as well as service quality. However, the government consistently reverted back to the PMH model despite the benefits of the PPP model. Evaluation: 8/10.
Article
Construction & Building Technology
Haiyan He, Lining Zheng, Guohua Zhou
Summary: Treating users as private partners in utility tunnel public-private partnership (PPP) projects benefits precise determination of user needs, operational efficiency enhancement, and user opposition reduction. The optimized scheme under the incentive mechanism is found to be more efficient than the original solution.
TUNNELLING AND UNDERGROUND SPACE TECHNOLOGY
(2022)
Article
Construction & Building Technology
Fang Bian, Heap-Yih Chong, Wei Zhang, Chao Ding
Summary: Governments have introduced public-private partnerships in energy efficient retrofits (PPP-EER) to reduce energy consumption, but how to choose an appropriate subsidy strategy remains unclear. This study used real option theory to simulate and evaluate the subsidy strategy in PPP-EER projects, demonstrating that the deferred option significantly impacts project value.
ENERGY AND BUILDINGS
(2021)
Article
Economics
Lanlan Luo, Ziran Zou, Shou Chen
Summary: Public-private partnership (PPP) projects have played a critical role in providing infrastructure products and services in China. This study investigates the impact of market risk and government credit risk on the discount rate for China's PPP projects using a consumption-based approach. The proposed discounting model provides direct evaluation guidance for China's PPP projects and a general analysis framework to determine the discount rate for global PPP projects.
ECONOMIC MODELLING
(2021)
Article
Oncology
A. S. Mansfield, Z. Wei, R. Mehra, A. T. Shaw, C. H. Lieu, P. M. Forde, A. E. Drilon, E. P. Mitchell, J. J. Wright, N. Takebe, E. Sharon, D. Hovelson, S. Tomlins, J. Zeng, K. Poorman, N. Malik, R. J. Gray, S. Li, L. M. McShane, L. Rubinstein, D. Patton, P. M. Williams, S. R. Hamilton, B. A. Conley, C. L. Arteaga, L. N. Harris, P. J. O'Dwyer, A. P. Chen, K. T. Flaherty
Summary: The NCI-MATCH study aims to evaluate the efficacy of targeted therapies in histology-agnostic malignancies with driver mutations. It was found that patients with rare tumors harboring ALK or ROS1 rearrangements may respond to crizotinib treatment.
NPJ PRECISION ONCOLOGY
(2022)
Review
Development Studies
Nannan Wang, Minxun Ma
Summary: This research fills the perceived gap in literature by reviewing sustainability-oriented PPP studies, aiming to better understand the relationship between PPP and sustainable development. Through examining the concept and development stages of sustainability-oriented PPP, along with analyzing the research status in this field, it provides insights for future research trends and highlights potential research gaps.
SUSTAINABLE DEVELOPMENT
(2021)
Article
Engineering, Manufacturing
Mohammad Ebrahim Nikoofal, Morteza Pourakbar, Mehmet Gumus
Summary: Global trade heavily relies on maritime transport, making it susceptible to security risks. Governments have implemented security programs to address this issue, and this paper explores the interaction between Customs inspection capacity and the incentives offered to foster collaboration between the government and private firms. Using game theory, the study finds that tailored operational incentives should be provided to encourage collaboration, while security incentives benefit all participants. The research also highlights the importance of balancing inspection capacity to avoid discouraging firms from collaborating.
PRODUCTION AND OPERATIONS MANAGEMENT
(2023)
Article
Green & Sustainable Science & Technology
Huimin Li, Fuqiang Wang, Chengyi Zhang, Lunyan Wang, Xiaowei An, Guanghua Dong
Summary: This paper investigates the selection of sustainable suppliers for water environmental treatment PPP projects, proposing an indicator system and decision-making methods based on the Shapely value method and TOPSIS decision model with IVIFSs. The results indicate that the sustainability of suppliers plays a crucial role in the sustainable development of projects, with financial capabilities and technology solutions being key factors to consider when choosing a supplier.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Energy & Fuels
Liu Jicheng, Yu Jing, Yin Yu, Wei Qiushuang
Summary: This study explores the behavioral strategies of private sectors in green energy public-private partnership projects using evolutionary game theory, finding that private sectors' cooperation strategies are influenced by factors such as base payoffs, social and environmental benefits, subsidies, cooperative incentives, transaction costs, and government punishment.
Article
Construction & Building Technology
Zeeshan Ahmad, Sajjad Mubin, Rehan Masood, Fahim Ullah, Malik Khalfan
Summary: A performance framework was developed to evaluate the application of PPP projects in developing countries. The framework was validated through case studies and showed differences in performance for some indicators, but similarities in practices. This study has important implications for developing countries transitioning to adopt PPP projects.
Article
Oncology
Deborah F. Wilsker, Allison M. Barrett, Angie B. Dull, Scott M. Lawrence, Melinda G. Hollingshead, Alice Chen, Shivaani Kummar, Ralph E. Parchment, James H. Doroshow, Robert J. Kinders
CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Saskia Litiere, Gaelle Isaac, Elisabeth G. E. De Vries, Jan Bogaerts, Alice Chen, Janet Dancey, Robert Ford, Stephen Gwyther, Otto Hoekstra, Erich Huang, Nancy Lin, Yan Liu, Sumithra Mandrekar, Lawrence H. Schwartz, Lalitha Shankar, Patrick Therasse, Lesley Seymour
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Meeting Abstract
Oncology
James V. Tricoli, Linda Zane, Robin Harrington, Laura Yee, Kneshay N. Harper, Ting-Chia Chang, Lyndsay Harris, Alice P. Chen, Keith Flaherty, Peter J. O'Dwyer, Barbara A. Conley, Cynthia Winter, Jennifer Lee, Paul M. Williams, Jeffrey Sklar, David Patton, Gregory J. Tsongalis, Stanley R. Hamilton, A. John Iafrate, Chris Alan Karlovich
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Meeting Abstract
Oncology
Robin Harrington, Biswajit Das, Tingting Jiang, Jennifer S. LoCoco, Rajesh Patidar, Amanda Peach, Chen Zhao, Corinne Camalier, Ting-Chia Chang, Alice P. Chen, Li Chen, Thomas Forbes, Sigrid Katz, Nikitha Nair, David J. Sims, Geraldine Helen O'Sullivan Coyne, Naoko Takebe, Paul M. Williams, Chris Alan Karlovich, James H. Doroshow
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Meeting Abstract
Oncology
Deborah Kay Armstrong, Kathleen N. Moore, Austin Miller, Katherine M. Bell-McGuinn, Russell J. Schilder, Paula M. Fracasso, Joan L. Walker, Linda R. Duska, Cara Amanda Mathews, Alice P. Chen, David M. O'Malley, Heidi J. Gray, Roisin Eilish O'Cearbhaill, Saketh R. Guntupalli, Andrea R. Hagemann, Carol Aghajanian
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Pharmacology & Pharmacy
Naoko Takebe, Jan H. Beumer, Shivaani Kummar, Brian F. Kiesel, Afshin Dowlati, Geraldine O'Sullivan Coyne, Richard Piekarz, Lawrence Rubinstein, Laura K. Fogli, Ulka Vaishampayan, Sanjay Goel, Cindy L. O'Bryant, Bassel F. El-Rayes, Vincent Chung, Heinz-Josef Lenz, Richard Kim, Chandra P. Belani, Joseph M. Tuscano, William Schelman, Nancy Moore, James H. Doroshow, Alice P. Chen
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Review
Oncology
Goldy C. George, Pedro C. Barata, Alicyn Campbell, Alice Chen, Jorge E. Cortes, David M. Hyman, Lee Jones, Thomas Karagiannis, Sigrid Klaar, Jennifer G. Le-Rademacher, Patricia LoRusso, Sumithra J. Mandrekar, Diana M. Merino, Lori M. Minasian, Sandra A. Mitchell, Sandra Montez, Daniel J. O'Connor, Syril Pettit, Elaine Silk, Jeff A. Sloan, Mark Stewart, Chris H. Takimoto, Gilbert Y. Wong, Timothy A. Yap, Charles S. Cleeland, David S. Hong
CANCER TREATMENT REVIEWS
(2019)
Article
Oncology
Julia W. Cohen, Brigitte C. Widemann, Joanne Derdak, Eva Dombi, Anne Goodwin, Jessica Dompierre, Uzoma Onukwubiri, Seth M. Steinberg, Geraldine O'Sullivan Coyne, Shivaani Kummar, Alice P. Chen, John Glod
PEDIATRIC BLOOD & CANCER
(2019)
Article
Oncology
Tony Navas, Robert J. Kinders, Scott M. Lawrence, Katherine Ferry-Galow, Suzanne Borgel, Melinda G. Hollingshead, Apurva K. Srivastava, Sergio Y. Alcoser, Hala R. Makhlouf, Rodrigo Chuaqui, Deborah F. Wilsker, Mariam M. Konate, Sarah B. Miller, Andrea Regier Voth, Li Chen, Tomas Vilimas, Jyothi Subramanian, Lawrence Rubinstein, Shivaani Kummar, Alice P. Chen, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment
Article
Oncology
Nilofer S. Azad, Robert J. Gray, Michael J. Overman, Jonathan D. Schoenfeld, Edith P. Mitchell, James A. Zwiebel, Elad Sharon, Howard Streicher, Shuli Li, Lisa M. McShane, Larry Rubinstein, David R. Patton, P. Mickey Williams, Brent Coffey, Stanley R. Hamilton, Nathan Bahary, J. Marie Suga, Hassan Hatoum, Jeffrey S. Abrams, Barbara A. Conley, Carlos L. Arteaga, Lyndsay Harris, Peter J. O'Dwyer, Alice P. Chen, Keith T. Flaherty
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Review
Cell Biology
Brian Ko, Naoko Takebe, Omozusi Andrews, Monish Ram Makena, Alice P. Chen
Summary: High-dose rhIL-2 has shown promise in treating metastatic melanoma and metastatic renal cell carcinoma, but its severe adverse effects have limited its adoption. Efforts have been made to improve the efficacy and safety of IL-2-based immunotherapies, including through biochemical modifications and engineered IL-2 variants. These modified IL-2 cytokines have shown improved activity in solid tumors beyond the FDA-approved indications and can be combined with other treatment modalities.
Review
Oncology
Alice P. Chen, Mariam Eljanne, Lyndsay Harris, Shakuntala Malik, Nita L. Seibel
Review
Pharmacology & Pharmacy
Sabrina S. Khan, Alice P. Chen, Naoko Takebe
EXPERT REVIEW OF PRECISION MEDICINE AND DRUG DEVELOPMENT
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Abhishek Jha, Alexander Ling, Corina Millo, Clara Chen, Melissa Gonzales, Mayank Patel, Isabel Tena, Divya Mamilla, Marianne Knue, Geraldine O'Sullivan Coyne, Alice Chen, Frank Lin, Naris Nilubol, Peter Herscovitch, Jorge Carrasquillo, David Taieb, Ali Civelek, Karel Pacak
JOURNAL OF NUCLEAR MEDICINE
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Abhishek Jha, Mamilla Divya, Melissa Gonzales, Mayank Patel, Corina Millo, Clara Chen, Alexander Ling, Isabel Tena, Marianne Knue, Geraldine O'Sullivan Coyne, Alice Chen, Naris Nilubol, Frank Lin, Stratakis Constantine, Peter Herscovitch, David Taieb, Ali Civelek, Jorge Carrasquillo, Karel Pacak
JOURNAL OF NUCLEAR MEDICINE
(2019)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)
