Is hyaluronic acid the perfect excipient for the pharmaceutical need?

Hyaluronic acid has become an interesting and important polymer as an excipient for pharmaceutical products due to its beneficial properties, like solubility, biocompatibility and biodegradation. To improve the properties of hyaluronic acid, different possibilities for chemical modifications are presented, and the opportunities as novel systems for drug delivery are discussed. This review gives an overview over the production of hyaluronic acid, the possibilities of its chemical modification and the current state of in vitro and in vivo research. Furthermore, market approved and commercially available products are reviewed and derivatives undergoing clinical trials and applying for market approval are shown. In particular, hyaluronic acid has been studied for different administrations in rheumatology, ophthalmology, local anesthetics, cancer treatment and bioengineering of tissues. The present work concludes with perspectives for future administration of pharmaceuticals based on hyaluronic acid.

Automated summary

Hyaluronic acid, as an important excipient for pharmaceutical products, has beneficial properties such as solubility, biocompatibility, and biodegradation. Chemical modifications can improve its properties and offer opportunities for novel drug delivery systems. It is widely researched for various administrations in fields like rheumatology, ophthalmology, and cancer treatment, showing promising prospects for future pharmaceutical administration.