Journal
BRAIN RESEARCH
Volume 1628, Issue -, Pages 17-28Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2015.06.037
Keywords
Homer; mGluR5; PIN1; Dopamine; NMDA receptor; Immediate early gene; Addiction; Reward learning; Reinforcement learning; Synaptic plasticity; Synaptic tag; Eligibility trace; Protoweight; Provisional weight; Neuronal selection
Categories
Funding
- NIDA [010309]
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Drug addiction and reward learning both involve mechanisms in which reinforcing neuromodulators participate in changing synaptic strength. For example, dopamine receptor activation modulates corticostriatal plasticity through a mechanism involving the induction of the immediate early gene Homer 1a, the phosphorylation of rnetabotropic glutamate receptor 5 (mGluR5)'s Homer ligand, and the enhancement of an NMDA receptor-dependent current. Inspired by hypotheses that Homer la functions selectively in recently-active synapses, we propose that Homer la is recruited by a synaptic tag to functionally discriminate between synapses that predict reward and those that do not. The involvement of Homer la in this mechanism further suggests that decaminutes-old firing patterns can define which synapses encode new information. This article is part of a Special Issue entitled SI:Addiction circuits. (C) 2015 Published by Elsevier B.V.
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