Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/ijms22094479
Keywords
iron; biomarkers; ferroptosis; neurodegeneration; Alzheimer’ s disease
Funding
- University of Torino
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Proper functioning of all organs, including the brain, requires iron, which is present in different forms in biological fluids. Clinical parameters for monitoring iron concentration in biological fluids may not detect circulating iron accurately, while indirect measurements like magnetic resonance imaging need further validation.
Proper functioning of all organs, including the brain, requires iron. It is present in different forms in biological fluids, and alterations in its distribution can induce oxidative stress and neurodegeneration. However, the clinical parameters normally used for monitoring iron concentration in biological fluids (i.e., serum and cerebrospinal fluid) can hardly detect the quantity of circulating iron, while indirect measurements, e.g., magnetic resonance imaging, require further validation. This review summarizes the mechanisms involved in brain iron metabolism, homeostasis, and iron imbalance caused by alterations detectable by standard and non-standard indicators of iron status. These indicators for iron transport, storage, and metabolism can help to understand which biomarkers can better detect iron imbalances responsible for neurodegenerative diseases.
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