Article
Cell Biology
Hao Liang, Mingxing Xu, Zhiyong Xiong, Kunpeng Hu, Jiarui Yang, Mingbo Cao, Zhaozhong Zhong, Zhicheng Yao, Meihai Deng, Bo Liu
Summary: Analyzing micro-ribonucleic acid (miRNA) profiling datasets from Gene Expression Omnibus (GEO) DataSet, this study identified three differential miRNAs as valuable markers in hepatocellular carcinoma (HCC), with hsa-let-7e showing potential as a novel diagnostic and prognostic biomarker. Experimental data revealed that upregulated let-7e promoted tumor cell growth and potentially controlled cancer cell proliferation through regulating mitochondrial apoptosis and autophagy.
Article
Oncology
Jianing Wu, Abdulrahman Al-Zahrani, Ozal Beylerli, Rinat Sufianov, Rustam Talybov, Svetlana Meshcheryakova, Galina Sufianova, Ilgiz Gareev, Albert Sufianov
Summary: This study found that circulating miR-181a/b, miR-410, and miR-155 could be useful diagnostic and prognostic biomarkers for high-grade gliomas.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chrysoula Mytareli, Danae A. Delivanis, Fani Athanassouli, Vassiliki Kalotychou, Marina Mantzourani, Eva Kassi, Anna Angelousi
Summary: Adrenocortical carcinoma is a rare endocrine malignancy with poor prognosis and limited therapeutic options. Multiple studies have validated more than 10 miRNAs as potential diagnostic and prognostic markers for ACC patients, but data on the therapeutic role of miRNAs are still limited. Further research is needed to fully understand the role of miRNA regulation in ACC.
Review
Pathology
Wen Bi, Jingjing Li, Mengqiu Xiong, Bei Pan, Zhongqiu Zhang, Lubanga Nasifu, Bangshun He, Ping Wang
Summary: MicroRNA-27a (miR-27a) is abnormally expressed in cancer patients and can serve as a potential diagnostic and prognostic biomarker. It is a valuable diagnostic biomarker in serum/plasma and can predict poor prognosis in cancer patients. However, its diagnostic value is slightly reduced in tumor tissue samples.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Virology
Brandon Bautista-Becerril, Guillermo Perez-Dimas, Paola C. Sommerhalder-Nava, Alejandro Hanono, Julio A. Martinez-Cisneros, Barbara Zarate-Maldonado, Evangelina Munoz-Soria, Arnoldo Aquino-Galvez, Manuel Castillejos-Lopez, Armida Juarez-Cisneros, Jose S. Lopez-Gonzalez, Angel Camarena
Summary: The COVID-19 pandemic has highlighted the importance of prognostic predictors and therapeutic targets in the disease. miRNA biomolecules have been shown to play a vital role in regulating genes associated with the pathophysiology of COVID-19 and can be used as predictors of complications and potential targets for treatment. However, further studies are needed to confirm these findings.
Article
Biochemistry & Molecular Biology
Zhendong Liu, Wang Zhang, Xingbo Cheng, Hongbo Wang, Lu Bian, Jialin Wang, Zhibin Han, Yanbiao Wang, Xiaoyu Lian, Binfeng Liu, Zhishuai Ren, Bo Zhang, Zhenfeng Jiang, Zhiguo Lin, Yanzheng Gao
Summary: This study revealed the overexpression of XRCC2 in glioma and its association with poor prognosis in patients. XRCC2 was found to be an independent risk factor for glioma prognosis. GSEA results suggested that overexpressed XRCC2 may promote malignant progression through cell cycle signaling pathways. Additionally, small molecule drugs targeting XRCC2 were identified to exert anti-glioma effects.
MOLECULAR MEDICINE
(2021)
Article
Biology
Ewelina Blazejowska, Tomasz Urbanowicz, Aleksandra Gasecka, Anna Olasinska-Wisniewska, Milosz J. Jaguszewski, Radoslaw Targonski, Lukasz Szarpak, Krzysztof J. Filipiak, Bartlomiej Perek, Marek Jemielity
Summary: Coronary artery bypass graft (CABG) surgery is a treatment for complex coronary artery stenosis by bypassing atherosclerotic lesions. Postoperative complications remain a challenge, with miRNAs showing potential as biomarkers for predicting outcomes. MiRNAs, noncoding RNA particles, change expression during CABG and could improve diagnosis and prognosis.
Review
Cell Biology
Qinlu Zhao, Xin Yuan, Lian Zheng, Miaomiao Xue
Summary: Cancer is a major challenge in global public health, and miRNA plays an important role in cancer. Abnormal levels of miR-30d-5p have been associated with various human tumor types, and miR-30d-5p plays a crucial role in tumor prognosis and cancer progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Jingxian Sun, Zhenying Sun, Ilgiz Gareev, Tao Yan, Xin Chen, Aamir Ahmad, Daming Zhang, Boxian Zhao, Ozal Beylerli, Guang Yang, Shiguang Zhao
Summary: The study revealed a significant decrease in exosomal miR-2276-5p expression in glioma patients compared to non-glioma patients. The expression level of miR-2276-5p was closely associated with the survival rates of patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Guoshun Zhang, Hua Shang, Bin Liu, Guikai Wu, Diyang Wu, Liuqing Wang, Shengnan Li, Zhiyuan Wang, Suying Wang, Juxiang Yuan
Summary: ATP2A1 is a potential prognostic biomarker in colorectal cancer, with high expression associated with significantly lower overall survival rates. Inhibiting the autophagy process by ATP2A1 can significantly suppress the proliferation of colorectal cancer cells.
FRONTIERS IN GENETICS
(2022)
Article
Biology
Faisal Aziz, Abhijit Chakraborty, Imran Khan, Josh Monts
Summary: This article discusses the role of miRNA-223 in cancer development and its potential as a diagnostic biomarker.
Article
Biotechnology & Applied Microbiology
Akshay Pramod Ware, Shama Prasada Kabekkodu, Arun Chawla, Bobby Paul, Kapaettu Satyamoorthy
Summary: In this study, the abnormal expression of miRNA clusters residing within copy number variations (CNVs) in bladder cancer was investigated. The study identified upregulated miRNA clusters on CNV gain regions and correlated certain miRNA clusters with patient survival. These miRNA clusters targeted downregulated genes in bladder cancer and identified potential hub genes for diagnosis and prognosis. Notably, the expression of certain miRNA clusters showed significant differences during cancer progression. Additionally, the upregulation of NOTCH1 by specific miRNA clusters may sensitize bladder cancer to methotrexate. An automated pipeline for integrated data analysis of multiple cancer types was also developed.
Article
Immunology
Jianwan Xie, Yanchu Li, Man Wang, Wenping He, Xinxin Zhao
Summary: The study revealed that miR-10a-3p was upregulated in patients with severe pneumonia, showing potential as a diagnostic and prognostic marker for the disease in combination with CRP.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Oncology
Safaa Turkistani, Bruna M. Sugita, Paolo Fadda, Rafael Marchi, Ali Afsari, Tammey Naab, Victor Apprey, Robert L. Copeland, Michael C. Campbell, Luciane R. Cavalli, Yasmine Kanaan
Summary: This study identified specific miRNAs associated with tumor size, LN, and REC status in AA TNBC patients with high discriminatory power. These miRNAs are involved in proteglycans, glycan, and cancer-associated pathways, and are significantly associated with lower survival rates.
Review
Oncology
Bin Wu, Kaikai Zhen, Lixia Guo, Chao Sun
Summary: The dysregulated microRNAs (miRNAs) have potential diagnostic and prognostic value in hepatoblastoma (HB). The meta-analysis results suggest that miRNAs have moderate diagnostic value in HB and potential as prognostic indicators.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Cell Biology
Irene Paterniti, Alessia Filippone, Irina Naletova, Valentina Greco, Sebastiano Sciuto, Emanuela Esposito, Salvatore Cuzzocrea, Enrico Rizzarelli
Summary: Spinal cord injury (SCI) can cause severe motor dysfunction and nervous system abnormalities. The conjugation of trehalose with l-carnosine (Tre-car) has been found to reduce inflammation in vitro and in vivo models of SCI. Tre-car decreased early inflammatory effects, oxidative stress, and apoptosis, and stimulated the release of neurotrophic factors and influenced Zn2+ homeostasis. Tre-car may be a promising therapeutic agent for treating SCI.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Oncology
Alessia Filippone, Giovanna Casili, Sarah Adriana Scuderi, Deborah Mannino, Marika Lanza, Michela Campolo, Irene Paterniti, Anna Paola Capra, Cristina Colarossi, Annalisa Bonasera, Sofia Paola Lombardo, Salvatore Cuzzocrea, Emanuela Esposito
Summary: This study investigates the interaction between propionate and PPAR-gamma in glioblastoma and suggests that targeting the PPAR-gamma/SCFAs axis may be a potential therapeutic approach for the management of glioblastoma.
Article
Biochemistry & Molecular Biology
Tiziana Genovese, Andrea Duranti, Francesco Monaco, Rosalba Siracusa, Roberta Fusco, Daniela Impellizzeri, Ramona D'Amico, Marika Cordaro, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: Idiopathic pulmonary fibrosis (IPF), a deadly lung condition, worsens over time and has no known cause. Traditional treatments for IPF, such as corticosteroids and immunomodulatory drugs, often have noticeable side effects and are not very effective. By inhibiting the fatty acid amide hydrolase (FAAH) enzyme, which breaks down endocannabinoids, it is possible to increase the levels of these natural pain-relieving compounds and reduce inflammation. In our study, we used a bleomycin-induced IPF model and found that administering URB878, an FAAH inhibitor, reduced histological changes, cell infiltration, pro-inflammatory cytokine production, inflammation, and nitrosative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alessia Filippone, Giovanna Casili, Marika Lanza, Sarah Adriana Scuderi, Alessio Ardizzone, Anna Paola Capra, Irene Paterniti, Michela Campolo, Salvatore Cuzzocrea, Emanuela Esposito
Summary: Film-forming substances such as xyloglucan, pea protein, and Opuntia ficus-indica extract (XPO) have shown potential in restoring skin barrier integrity and may serve as alternative treatments for psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Alessia Filippone, Laura Cucinotta, Valentina Bova, Marika Lanza, Giovanna Casili, Irene Paterniti, Michela Campolo, Salvatore Cuzzocrea, Emanuela Esposito
Summary: Moderate traumatic brain injury (mTBI) is associated with emotional dysregulation. This study investigates the role of LRRK2 in reducing depression-related symptoms after mTBI and tests the antidepressant effects of LRRK2 inhibition by PF-06447475. The results show that mTBI promotes the development of depression-like behavior, but LRRK2 inhibition reduces histological damage and behavioral disturbances, suggesting an antidepressant effect.
Review
Biochemistry & Molecular Biology
Federica Rey, Clarissa Berardo, Erika Maghraby, Alessia Mauri, Letizia Messa, Letizia Esposito, Giovanna Casili, Sara Ottolenghi, Eleonora Bonaventura, Salvatore Cuzzocrea, Gianvincenzo Zuccotti, Davide Tonduti, Emanuela Esposito, Irene Paterniti, Cristina Cereda, Stephana Carelli
Summary: Oxygen imbalance can have detrimental effects on the brain, leading to various neurological disorders. The dysfunctions caused by oxygen imbalance in neurodegenerative and pediatric neurological disorders result from redox imbalance. This review focuses on the underlying dysfunction in redox and potential therapeutic strategies for these conditions.
Article
Biochemistry & Molecular Biology
Ylenia Marino, Alessia Arangia, Marika Cordaro, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Rosalia Cupi, Alessio Filippo Peritore, Enrico Gugliandolo, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: The study found that IL-6 plays a crucial role in fibromyalgia by activating the Jak/STAT3 pathway, increasing chemokine levels, and activating neuroinflammatory cells. Additionally, anti-IL-6 receptor antibody can provide analgesic effects and inhibit inflammatory responses. These findings may provide new insights for the treatment of fibromyalgia.
Article
Biochemistry & Molecular Biology
Marika Lanza, Laura Cucinotta, Giovanna Casili, Alessia Filippone, Rossella Basilotta, Anna Paola Capra, Michela Campolo, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
Summary: This study aimed to evaluate the inhibitory effect of Antrodia camphorata (AC) administration on neuroinflammation and oxidative stress in a murine model of Parkinson's disease (PD). The results showed that AC treatment significantly reduced PD-related pathological changes, increased tyrosine hydroxylase expression, reduced alpha-synuclein-positive neurons, restored the myelination process of neurons associated with PD, and attenuated neuroinflammation. Furthermore, AC was able to reduce oxidative stress induced by MPTP injection. This study highlights AC as a potential therapeutic agent for neurodegenerative disorders such as PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Livia Interdonato, Ylenia Marino, Ramona D'Amico, Marika Cordaro, Rosalba Siracusa, Daniela Impellizzeri, Francesco Macri, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: This study investigates the molecular mechanisms underlying endometriosis and how they can be modulated by Actaea racemosa (AR). The findings show that AR can reduce the size and histological morphology of the lesions and suppress the disease development through regulating multiple pathways, including cell proliferation, apoptosis, antioxidant, and anti-inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alessia Arangia, Agnese Ragno, Marika Cordaro, Ramona D'Amico, Rosalba Siracusa, Roberta Fusco, Francesca Marino Merlo, Antonella Smeriglio, Daniela Impellizzeri, Salvatore Cuzzocrea, Giuseppina Mandalari, Rosanna Di Paola
Summary: The study evaluated the antioxidant and anti-inflammatory effects of almond skin extract (ASE) and found that it inhibited the formation of ROS and apoptosis in vitro, and restored tissue changes and decreased inflammation in an in vivo model. The mechanisms of action could be related to the inhibition of the pro-inflammatory nuclear factor NF-κB and activation of the Nrf2 antioxidant pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Alberto Repici, Alessio Ardizzone, Alessia Filippone, Cristina Colarossi, Marzia Mare, Gabriele Raciti, Deborah Mannino, Salvatore Cuzzocrea, Irene Paterniti, Emanuela Esposito
Summary: Brain tumors are a heterogeneous group of neoplasms affecting populations of all ages. Glioblastoma (GB), the most common primary brain tumor, often leads to death within a few months after diagnosis. Immunotherapy, particularly targeting interleukin 21 (IL-21), appears to be a promising approach to improve the survival rate of GB patients. The review evaluates the potential use of IL-21 and its mechanisms in the progression of GB.
Article
Pharmacology & Pharmacy
Fabrizio Calapai, Ilaria Ammendolia, Luigi Cardia, Mariaconcetta Curro, Gioacchino Calapai, Emanuela Esposito, Carmen Mannucci
Summary: Risankizumab is a safe and effective treatment for moderate-to-severe plaque psoriasis and psoriatic arthritis, according to post-marketing analysis of real-world data. The most frequently reported serious adverse reactions to risankizumab include infections, cancer, nervous system and cardiac disorders. Despite the limitations of the study, the safety profile of risankizumab is consistent with previous clinical trials and further research is needed to explore the occurrence of malignancies and their sex distribution as adverse reactions.
Editorial Material
Biochemistry & Molecular Biology
Salvatore Cuzzocrea, Rosalia Crupi
