Citric Acid Cycle Metabolites Predict Infarct Size in Pigs Submitted to Transient Coronary Artery Occlusion and Treated with Succinate Dehydrogenase Inhibitors or Remote Ischemic Perconditioning

Effect of COMBinAtion therapy with remote ischemic conditioning and exenatide on the Myocardial Infarct size: a two-by-two factorial randomized trial (COMBAT-MI)

(2021) Bruno García del Blanco et al.   BASIC RESEARCH IN CARDIOLOGY

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo

(2020) Hiran A. Prag et al.   CARDIOVASCULAR DRUGS AND THERAPY

Mechanism of succinate efflux upon reperfusion of the ischemic heart

(2020) Hiran A Prag et al.   CARDIOVASCULAR RESEARCH

Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus

(2020) Nichlas Riise Jespersen et al.   Scientific Reports

Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury

(2019) Sean M. Davidson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive

(2019) M. Kohlhauer et al.   BASIC RESEARCH IN CARDIOLOGY

Co‐morbidities and co‐medications as confounders of cardioprotection ‐ does it matter in the clinical setting?

(2019) Petra Kleinbongard et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial

(2019) Derek J Hausenloy et al.   LANCET

Serum metabolite profiling of ST‐segment elevation myocardial infarction using liquid chromatography quadrupole time‐of‐flight mass spectrometry

(2019) Gulsah Gundogdu et al.   BIOMEDICAL CHROMATOGRAPHY

Succinate in ischemia: Where does it come from?

(2019) Christos Chinopoulos   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Metabolomic characterization of myocardial ischemia-reperfusion injury in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention

(2019) Arun Surendran et al.   Scientific Reports

Influence of long-term treatment with glyceryl trinitrate on remote ischemic conditioning

(2018) Marie Hauerslev et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Control of mitochondrial superoxide production by reverse electron transport at complex I

(2018) Ellen L. Robb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Inhibition of Succinate Dehydrogenase in Reperfused Myocardium with Intracoronary Malonate Reduces Infarct Size

(2018) Laura Valls-Lacalle et al.   Scientific Reports

Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity

(2018) Jimmy Zhang et al.   Cell Reports

Metabolomic Profiling in Acute ST‐Segment–Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia–Reperfusion Injury

(2018) Matthias Kohlhauer et al.   Journal of the American Heart Association

The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection

(2018) Derek J Hausenloy et al.   CARDIOVASCULAR RESEARCH

The role of succinate and ROS in reperfusion injury – A critical appraisal

(2017) Tatyana N. Andrienko et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Succinate metabolism: a new therapeutic target for myocardial reperfusion injury

(2016) Victoria R. Pell et al.   CARDIOVASCULAR RESEARCH

Ischaemic conditioning and reperfusion injury

(2016) Derek J. Hausenloy et al.   Nature Reviews Cardiology

Citric Acid Cycle Metabolites Predict the Severity of Myocardial Stunning and Mortality in Newborn Pigs

(2016) Janus Adler Hyldebrandt et al.   Pediatric Critical Care Medicine

Efectos aditivos de la exenatida, la glucosa-insulina-potasio y el condicionamiento isquémico a distancia frente a las arritmias ventriculares de la reperfusión en cerdos

(2016) Juan J. Alburquerque-Béjar et al.   REVISTA ESPANOLA DE CARDIOLOGIA

Combination therapy with remote ischaemic conditioning and insulin or exenatide enhances infarct size limitation in pigs

(2015) Juan José Alburquerque-Béjar et al.   CARDIOVASCULAR RESEARCH

Succinate dehydrogenase inhibition with malonate during reperfusion reduces infarct size by preventing mitochondrial permeability transition

(2015) Laura Valls-Lacalle et al.   CARDIOVASCULAR RESEARCH

Cardioprotection by combined intrahospital remote ischaemic perconditioning and postconditioning in ST-elevation myocardial infarction: the randomized LIPSIA CONDITIONING trial

(2015) Ingo Eitel et al.   EUROPEAN HEART JOURNAL

Cardiovascular risk in post-myocardial infarction patients: nationwide real world data demonstrate the importance of a long-term perspective

(2015) Tomas Jernberg et al.   EUROPEAN HEART JOURNAL

Remote Ischemic Conditioning

(2015) Gerd Heusch et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Remote conditioning the heart overview: translatability and mechanism

(2014) Michael Rahbek Schmidt et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Triple Therapy Greatly Increases Myocardial Salvage During Ischemia/Reperfusion in the in situ Rat Heart

(2013) Xi-Ming Yang et al.   CARDIOVASCULAR DRUGS AND THERAPY

Remote Ischemic Post-Conditioning of the Lower Limb During Primary Percutaneous Coronary Intervention Safely Reduces Enzymatic Infarct Size in Anterior Myocardial Infarction

(2013) Gabriele Crimi et al.   JACC-Cardiovascular Interventions

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

(2013) Derek J. Hausenloy et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions

(2012) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet P2Y12 Blockers Confer Direct Postconditioning-Like Protection in Reperfused Rabbit Hearts

(2012) Xi-Ming Yang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Controversies in Cardiovascular MR Imaging: T2-weighted Imaging Should Not Be Used to Delineate the Area at Risk in Ischemic Myocardial Injury

(2012) Pierre Croisille et al.   RADIOLOGY

Combined local ischemic postconditioning and remote perconditioning recapitulate cardioprotective effects of local ischemic preconditioning

(2010) Ping Xin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Remote postconditioning by humoral factors in effluent from ischemic preconditioned rat hearts is mediated via PI3K/Akt-dependent cell-survival signaling at reperfusion

(2010) L. Breivik et al.   BASIC RESEARCH IN CARDIOLOGY

Inhibition of the malate–aspartate shuttle by pre-ischaemic aminooxyacetate loading of the heart induces cardioprotection

(2010) Nicolaj Brejnholt Støttrup et al.   CARDIOVASCULAR RESEARCH

Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial

(2010) Hans Erik Bøtker et al.   LANCET

Lethal reperfusion injury in acute myocardial infarction: facts and unresolved issues

(2009) D. Garcia-Dorado et al.   CARDIOVASCULAR RESEARCH