Article
Public, Environmental & Occupational Health
Andrea't Mannetje, Jonathan Coakley, Jeroen Douwes
Summary: This study conducted the first national biomonitoring survey of urinary phthalate metabolites in the New Zealand population. The results showed that phthalate exposure is widespread in both children and adults in New Zealand, with children having higher levels of exposure for most metabolites compared to adults. Some individuals exceeded the health-based exposure guidance values for DBP and DEHP, indicating potential health effects from exposure to these phthalates.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Catherine Pirard, Corinne Charlier
Summary: A human biomonitoring study was conducted in Liege, Belgium in 2015. Levels of certain chemicals were measured in the urine of 252 participants and information about their lifestyles, food habits, and home environment were collected. A follow-up study was conducted in 2018, which showed a decrease in levels of some chemicals but an increase in levels of others.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Susanna Edith Medellin-Garibay, Luz Eugenia Alcantara-Quintana, Ana Socorro Rodriguez-Baez, Julia Sagahon-Azua, Maribel Rodriguez-Aguilar, Maria de los Angeles Hernandez Cueto, Jose Esteban Munoz Medina, Rosa del Carmen Milan-Segovia, Rogelio Flores-Ramirez
Summary: This study reveals high levels of phthalates, particularly MEHP, in urine samples of women with CC associated with human papillomavirus (HPV) infection. Further studies are needed to evaluate the possible role of phthalates in synergy with HPV in progression to CC.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Kai-Wei Liao, Wei-Hsiang Chang, Wei-Chun Chou, Han-Bin Huang, Alexander Waits, Pau-Chung Chen, Po-Chin Huang
Summary: The study investigated the phthalate exposure levels in the Taiwanese population and found variations in exposure levels among different age groups and regions. Reference values (RVs) for phthalate metabolites in Taiwan were established in the current study, aiding in further monitoring and investigation of food safety and environmental protection in the region.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Engineering, Environmental
Miao Liu, Lei Zhao, Linlin Liu, Wenting Guo, Huihua Yang, Shuang Chen, Jie Yu, Meng Li, Qin Fang, Xuefeng Lai, Liangle Yang, Rui Zhu, Xiaomin Zhang
Summary: This panel study found a significant association between certain phthalate metabolites and reduced eGFR in children, with age and weight status possibly modifying these relationships. Additionally, multiple cytokines related to eGFR were increased in the presence of phthalate metabolites, with CCL27 and CXCL1 potentially mediating the association between MEP and eGFR.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Christoph Schmidtkunz, Katja Kuepper, Till Weber, Gabriele Leng, Marike Kolossa-Gehring
Summary: A study in Germany analyzed the levels of two oxidized metabolites of 4-MBC in urine samples from young adults from 1995 to 2019. The results showed a decreasing trend in 4-MBC exposure in Germany in recent years, possibly due to reduced use of 4-MBC in the cosmetic industry.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Xiaoyong Tian, Kaiqin Huang, Yangyang Liu, Kaixin Jiang, Ranran Liu, Juntao Cui, Fei Wang, Yingxin Yu, Huanhuan Zhang, Meiqing Lin, Shengtao Ma
Summary: This study investigated the distribution of nineteen ingredients of personal care products in paired human hair, nail, and urine samples. The concentrations of mPAEs, BPs, and AAs varied across different matrices and showed significant differences between male and female. These results suggest the need to use multiple matrices to comprehensively assess the risk of ingredients of personal care products to human health.
ENVIRONMENTAL POLLUTION
(2023)
Article
Toxicology
T. Schettgen, J. Bertram, J. Krabbe, R. Christoforou, M. Schweiker, A. Esser, M. Moeller, P. Ziegler, T. Kraus
Summary: The absorption and urinary kinetics of 1,3-dichlorobenzene and its metabolites were investigated in 10 human volunteers after controlled inhalative exposure. Dose-response relationships were observed for all investigated parameters, and the use of filter masks significantly decreased the internal exposure.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Environmental Sciences
Di Gao, Zhiyong Zou, Yanhui Li, Manman Chen, Ying Ma, Li Chen, Xijie Wang, Zhaogeng Yang, Yanhui Dong, Jun Ma
Summary: Research suggests that phthalate exposure during childhood may significantly increase the risk of dyslipidemia and higher levels of lipid profiles, particularly in boys. This study found that Chinese children are widely exposed to phthalates.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Pilar Requena, Celia Perez-Diaz, Vicente Mustieles, Francisco M. Peinado, Josefa Leon, Francisco M. Perez-Carrascosa, Hanne Frederiksen, Inmaculada Salcedo-Bellido, Rocio Barrios-Rodriguez, Juan Pedro Arrebola
Summary: This study investigates the associations between human phthalate exposure and the onset of chronic diseases with an immunological component. The results suggest that certain phthalates are correlated with cytokines and acute phase proteins, indicating potential subclinical immuno-inflammatory actions of these pollutants.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Jingyu Qu, Wei Xia, Xi Qian, Yongning Wu, Jingguang Li, Sheng Wen, Shunqing Xu
Summary: Despite being restricted by many authorities, di (2-ethylhexyl) phthalate (DEHP) is still widely detected in the environment and biospecimens. Exposure levels varied significantly between countries with children having the highest levels. While most hazard quotients were less than 1, the risk behind cannot be ignored. In the general population, DEHP exposure levels showed a downtrend over time, with efforts to reduce exposure still lacking on a global scale.
Article
Environmental Sciences
Diana C. Pacyga, Joseph C. Gardiner, Jodi A. Flaws, Zhong Li, Antonia M. Calafat, Susan A. Korrick, Susan L. Schantz, Rita S. Strakovsky
Summary: This study found that exposure to phthalates may impact gestational hormones in pregnant women, with potential for associations that vary by gestational age and fetal sex. Specifically, certain phthalate metabolites were positively associated with total estrogen and testosterone levels, while negatively associated with the estrogen/androgen ratio.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Yanxia Zhang, Biao Huang, Huan He, Xinkai Wang, Clive E. Sabel, Marianne Thomsen, Zhikun Chen, Weixi Wang
Summary: Agricultural plastic greenhouse (PG) production can prolong the growing season of crops to meet domestic demand in countries like China. A pilot study in Shaanxi Province found that summer workers had significantly higher levels of phthalate metabolites compared to winter, with 62.3% of workers showing exposure risks and the largest pathways being consuming produce and inhaling in PGs. Efforts to protect workers from phthalate exposure risks and eliminate phthalate-containing plastic materials in PGs are essential to ensure food safety.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Hao Wang, Yixin Cui, Fan Zhang, Ruihan Song, Longzhu Zhao, Miaomiao Han, Xiaoli Shen
Summary: Phthalate metabolites have been detected in urine of most US population and pose a public health problem. However, the association between phthalate metabolites and hyperuricemia has been under-studied. This study aimed to evaluate the association between phthalate metabolites and hyperuricemia in US adults. The results indicate that several urinary phthalate metabolites are positively associated with the odds of hyperuricemia.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Maha M. Al-Bazi, Taha A. Kumosani, Abdulrahman L. Al-Malki, Kurunthachalam Kannan, Said S. Moselhy
Summary: This study investigated the incidence of type 2 diabetes mellitus in Saudi subjects and found significant concentrations of urinary phthalate metabolites in diabetic patients. Additionally, the study suggests that phthalate toxicity may contribute to insulin resistance and the development of type 2 diabetes mellitus.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Manuel Lozano, Paul Yousefi, Karin Broberg, Raquel Soler-Blasco, Chihiro Miyashita, Giancarlo Pesce, Woo Jin Kim, Mohammad Rahman, Kelly M. Bakulski, Line S. Haug, Atsuko Ikeda-Araki, Guy Huel, Jaehyun Park, Caroline Relton, Martine Vrijheid, Sheryl Rifas-Shiman, Emily Oken, John F. Dou, Reiko Kishi, Kristine B. Gutzkow, Isabella Annesi-Maesano, Sungho Won, Marie-France Hivert, M. Daniele Fallin, Marina Vafeiadi, Ferran Ballester, Mariona Bustamante, Sabrina Llop
Summary: This study found associations between prenatal MeHg exposure and cord blood DNA methylation levels, but limited evidence of these relationships in blood from 7 to 8 year-old children.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Sachiko Itoh, Keiko Yamazaki, Satoshi Suyama, Atsuko Ikeda-Araki, Chihiro Miyashita, Yu Ait Bamai, Sumitaka Kobayashi, Hideyuki Masuda, Takeshi Yamaguchi, Houman Goudarzi, Emiko Okada, Ikuko Kashino, Takuya Saito, Reiko Kishi
Summary: This study investigated the impact of maternal PFAS exposure on children's ADHD symptoms, finding significant inverse associations between some PFAS in maternal serum and ADHD symptoms among first-born children. Only one significant association was found, with maternal FT4 mediating 17.6% of the estimated effect of perfluoroundecanoic acid exposure on hyperactivity-impulsivity among firstborn children.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Public, Environmental & Occupational Health
Yukihiro Sato, Eiji Yoshioka, Yasuaki Saijo, Toshinobu Miyamoto, Hiroshi Azuma, Yusuke Tanahashi, Yoshiya Ito, Sumitaka Kobayashi, Machiko Minatoya, Yu Ait Bamai, Keiko Yamazaki, Sachiko Itoh, Chihiro Miyashita, Atsuko Ikeda-Araki, Reiko Kishi
Summary: This study examined the association between orofacial clefts in infants and lower respiratory tract infections (LRTIs). The results showed that infants with cleft lip and palate (CLP) and cleft lip (CL) had a higher risk of LRTIs compared to the control group. The duration of breastfeeding appeared to mediate the association between CLP and LRTIs.
JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yukihiro Sato, Eiji Yoshioka, Yasuaki Saijo, Yasuhito Kato, Ken Nagaya, Satoru Takahashi, Yoshiya Ito, Sumitaka Kobayashi, Yu Ait Bamai, Keiko Yamazaki, Sachiko Itoh, Chihiro Miyashita, Atsuko Ikeda-Araki, Reiko Kishi
Summary: This study found no associations between isolated orofacial clefts and sleep duration in children at different ages. Children with isolated orofacial clefts had adequate sleep duration.
CLEFT PALATE-CRANIOFACIAL JOURNAL
(2022)
Article
Pediatrics
Yukihiro Sato, Eiji Yoshioka, Yasuaki Saijo, Yasuhito Kato, Ken Nagaya, Satoru Takahashi, Yoshiya Ito, Sumitaka Kobayashi, Yu Ait Bamai, Keiko Yamazaki, Sachiko Itoh, Chihiro Miyashita, Atsuko Ikeda-Araki, Reiko Kishi
Summary: This study aimed to document the complication status of infants with orofacial clefts born between 2011 and 2014 in Japan. The study found that isolated orofacial clefts were the most common subtype, congenital heart disease was the most frequently associated anomaly, and trisomy 13 was the most frequently associated syndrome in infants with cleft lip and palate.
CONGENITAL ANOMALIES
(2023)
Article
Environmental Sciences
Sumitaka Kobayashi, Sachiko Itoh, Chihiro Miyashita, Yu Ait Bamai, Takeshi Yamaguchi, Hideyuki Masuda, Mariko Itoh, Keiko Yamazaki, Naomi Tamura, Sharon J. B. Hanley, Atsuko Ikeda-Araki, Yasuaki Saijo, Yoshiya Ito, Miyuki Iwai-Shimada, Shin Yamazaki, Michihiro Kamijima, Reiko Kishi
Summary: Prenatal exposure to metal can potentially cause neurodevelopmental delays in children. This study found a slight association between selenium levels in maternal blood and increased risks of neurodevelopmental delays in children up to the age of 4 years.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Hideyuki Masuda, Sumitaka Kobayashi, Chihiro Miyashita, Sachiko Itoh, Yu Ait Bamai, Yasuaki Saijo, Yoshiya Ito, Reiko Kishi, Atsuko Ikeda-Araki
Summary: Maternal intake of folic acid supplements is not associated with wheeze and eczema in offspring, while dietary folate intake is positively associated with wheeze at the age of 2. Further studies are needed to confirm the results and explore potential confounders.
Article
Allergy
Houman Goudarzi, Atsuko Ikeda-Araki, Yu Ait Bamai, Sachiko Ito, Tasuku Inao, Isao Yokota, Chihiro Miyashita, Reiko Kishi, Satoshi Konno
Summary: This study assessed the determinants and typical range of Th2 biomarkers in 9-11-year-old children. The results showed that wheezing, rhinitis, and eczema were significantly associated with increased blood eosinophils. Allergic conditions were also associated with FeNO and total serum IgE levels, with smaller associations compared to blood eosinophils. Secondhand smoke exposure was inversely associated with blood eosinophils. These findings have important implications for interpreting Th2 biomarkers in children.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Environmental Sciences
Keiko Yamazaki, Atsuko Ikeda-Araki, Chihiro Miyashita, Naomi Tamura, Toshio Yoshikawa, Takashi Hikage, Manabu Omiya, Masahiro Mizuta, Miwa Ikuyo, Kazuhiro Tobita, Teruo Onishi, Masao Taki, Soichi Watanabe, Reiko Kishi
Summary: This study examined children's exposure to radiofrequency electromagnetic fields (RF-EMF) in Japan and found that it was lower than in Europe. The most significant contributor to total exposure was the downlink signals from mobile phone base stations, while Wireless LAN and digital TV had minimal impact. Urban residence was consistently associated with increased exposure in four frequency bands. There was also a link between RF-EMF exposure and inattention/hyperactivity symptoms in children.
ENVIRONMENTAL RESEARCH
(2023)
Editorial Material
Engineering, Environmental
James R. Mihelcic, Ricardo O. Barra, Bryan W. Brooks, Miriam L. Diamond, Matthew J. Eckelman, Jacqueline MacDonald Gibson, Sunny Guidotti, Atsuko Ikeda-Araki, Manish Kumar, Ynoussa Maiga, Jennifer McConville, Shelly L. Miller, Valeria Pizarro, Fernando Rosario-Ortiz, Shuxiao Wang, Julie B. Zimmerman
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Medicine, General & Internal
Kentaro Nakanishi, Yasuaki Saijo, Eiji Yoshioka, Yukihiro Sato, Yasuhito Kato, Ken Nagaya, Satoru Takahashi, Yoshiya Ito, Sumitaka Kobayashi, Chihiro Miyashita, Atsuko Ikeda-Araki, Reiko Kishi
Summary: This study aimed to investigate the association between maternal multimorbidity and adverse perinatal outcomes such as preterm delivery and low birth weight. The study found a significant association between maternal multimorbidity and adverse perinatal outcomes, including preterm birth, low birth weight, and small for gestational age.
Editorial Material
Engineering, Environmental
James R. Mihelcic, Ricardo O. Barra, Bryan W. Brooks, Miriam L. Diamond, Matthew J. Eckelman, Jacqueline MacDonald Gibson, Sunny Guidotti Atsuko Ikeda-Araki, Manish Kumar, Ynoussa Maiga, Jennifer McConville, Shelly L. Miller, Valeria Pizarro Fernando Rosario-Ortiz, Shuxiao Wang, Julie B. Zimmerman
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2023)
Article
Genetics & Heredity
Hisanori Fukunaga, Atsuko Ikeda
Summary: This study provides a comprehensive understanding of the genetic and physiological significance of mtDNA copy number in cord blood or peripheral blood from three generations, involving over 1000 individuals. The findings suggest that mtDNA copy number could serve as a transgenerational biomarker for assessing perinatal outcomes, and appropriate medical interventions could improve outcomes through quantitative changes in mtDNA.
Article
Environmental Sciences
Yuki Kunori, Yasuaki Saijo, Eiji Yoshioka, Yukihiro Sato, Tomoko Kanaya, Kentaro Nakanishi, Yasuhito Kato, Ken Nagaya, Satoru Takahashi, Yoshiya Ito, Sachiko Itoh, Sumitaka Kobayashi, Chihiro Miyashita, Atsuko Ikeda-Araki, Reiko Kishi
Summary: This study aimed to investigate the relationship between urinary cotinine concentration (UCC) during pregnancy and adverse birth outcomes related to fetal growth. The study found dose-response relationships between UCC and the risks of preterm birth, low birth weight, and small-for-gestational age.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Rahel Mesfin Ketema, Yu Ait Bamai, Chihiro Miyashita, Takeshi Saito, Reiko Kishi, Atsuko Ikeda-Araki
Summary: This study investigated the effect of a mixture of phthalate metabolites on wheeze, rhino-conjunctivitis, and eczema, and assessed the potential mediation effect of oxidative stress. The results showed significant associations between phthalate metabolite exposure and wheeze and eczema. The main contributors to these associations were DEHP and DINP metabolites. However, no mediation effect of oxidative stress was observed.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Public, Environmental & Occupational Health
Dewan Muhammad Shoaib, Tanvir Ahmed, Kazy Farhat Tabassum, Mehedi Hasan, Fazle Sharior, Mahbubur Rahman, Makfie Farah, Md Azizur Rahman, Alauddin Ahmed, James B. Tidwell, Mahbub-Ul Alam
Summary: An intervention was implemented in Bangladesh during COVID-19 to reduce occupational health risks for waste and sanitation workers. The intervention involved training and distribution of personal protective equipment (PPE). The study found that the intervention improved workers' knowledge, attitude, and practice regarding PPE usage.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Andreas Kortenkamp, Olwenn Martin, Eleni Iacovidou, Martin Scholze
Summary: The European Food Safety Authority's downward revision of the Health-based Guidance Value for bisphenol A (BPA) has led to disagreements with other regulatory agencies, particularly the German Federal Institute for Risk Assessment. The differing views between EFSA and BfR are driven by their respective selection of endpoints and study evaluation systems, as well as their acceptance or refusal of immunotoxic effects as a basis for establishing a Health-based Guidance Value.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Shizhen He, Bjorn Lundberg, Jenny Hallberg, Susanna Klevebro, Goran Pershagen, Kristina Eneroth, Erik Melen, Matteo Bottai, Olena Gruzieva
Summary: Early life air pollution exposure and abnormal inflammation-related protein profiles may interact synergistically towards lower lung function in infants.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Paulien Cleys, Emilie Hardy, Yu Ait Bamai, Giulia Poma, Adam Cseresznye, Govindan Malarvannan, Paul T. J. Scheepers, Susana Viegas, Simo P. Porras, Tiina Santonen, Lode Godderis, Jelle Verdonck, Katrien Poels, Carla Martins, Maria Joao Silva, Henriqueta Louro, Inese Martinsone, Lasma Akulova, An van Nieuwenhuyse, Martien Graumans, Selma Mahiout, Radu Corneliu Duca, Adrian Covaci
Summary: The aim of this study was to assess the exposure of e-waste workers to phthalates and alternative plasticizers. The results showed that e-waste workers had higher urinary concentrations of phthalates and metabolites compared to non-occupationally exposed controls. However, no significant differences were found between pre-and post-shift concentrations in the e-waste workers.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Karolina Bralewska
Summary: This review study examines the concentrations of various air pollutants in fire stations, identifies the limitations and strengths of existing research, identifies research gaps and challenges, and suggests potential solutions for reducing firefighter exposure to air pollution at fire stations.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)