Article
Oncology
Yoshihide Nagasako, Masahiro Suzuki, Tetsuji Iriyama, Yoko Nagasawa, Yoshiki Katayama, Kaori Masuda
Summary: The Glasgow Prognostic Score (GPS) was optimized with thrombocytopenia to enhance prognostic value, and it exhibited high specificity and positive likelihood ratio for predicting 3-day mortality in advanced cancer patients admitted to an acute palliative care unit (APCU). This combination could assist in making personal and clinical decisions for patients with limited time of survival.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Health Care Sciences & Services
Gabriella da Costa Cunha, Karla Santos da Costa Rosa, Emanuelly Varea Maria Wiegert, Livia Costa de Oliveira
Summary: Inflammatory biomarkers have prognostic value in terminal cancer patients receiving palliative care. The cutoff points for CRP, leukocytes, neutrophils, NLR, CAR, and modified Glasgow Prognostic Score were identified for predicting death within 90 days. Among these biomarkers, CAR showed excellent discrimination power and predictive accuracy.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2021)
Article
Oncology
Jessica Y. Islam, April Deveaux, Rebecca A. Previs, Tomi Akinyemiju
Summary: The study reveals that there are racial disparities in palliative care utilization among patients with metastatic gynecological cancer, with NH-Black and Hispanic patients being less likely to utilize palliative care compared to NH-White patients.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Medicine, General & Internal
Minoh Ko, Sunghwan Kim, Sung Yun Suh, Yoon Sook Cho, In-Wha Kim, Shin Hye Yoo, Ju-Yeun Lee, Jung Mi Oh
Summary: This study evaluated the clinical outcomes of a pharmacist-led deprescribing service for terminal cancer patients. The results showed that the service effectively reduced the use of preventive medications and resolved medication-related problems. Pharmacists' interventions were well accepted.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Yan-Mei Dai, Ya-Ting Huang, Min-Yu Lai, Hsueh-Erh Liu, Chih-Chung Shiao
Summary: In a study on palliative care for terminal cancer patients, initiating HSC 8-60 days before death can improve QOC, while initiating HSC 15-90 days before death can save medical expenses.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Hematology
Naohiro Miyashita, Kota Ohashi, Mariko Fujita, Toru Hosoda, Yasufumi Kawasaki, Madoka Takimoto, Masahiro Onozawa
Summary: We conducted a retrospective evaluation of 180 patients in the terminal phase of haematological malignancies (HM) receiving home medical care (HMC), and identified several prognostic factors associated with overall survival (OS). Based on these findings, we developed a novel prognostic scoring system, called Japan palliative haematological oncology prognostic estimates, which successfully differentiated patients into four risk groups with different survival outcomes. This is the first study to investigate prognostic factors in HM patients receiving HMC, highlighting the importance of providing reliable prognosis information to patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Medicine, General & Internal
Ana Rute Preis Silva, Augusto Vanni Bodanezi, Emanuely Silva Chrun, Mariah Luz Lisboa, Alessandra R. de Camargo, Etiene Andrade Munhoz
Summary: This study synthesized the published evidence on oral conditions, impact, management, and challenges among palliative patients. The results revealed that oral manifestations in terminal oncologic patients include oral candidiasis, dry mouth, dysphagia, dysgeusia, oral mucositis, and orofacial pain. Establishing a protocol based on scientific evidence is crucial for the multidisciplinary team involved in the care of patients in palliative care.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Oncology
Torbjorn Paulsen, Heidi Liland, Tor Age Myklebust, Kristina Lindemann
Summary: This study assesses end-of-life care among patients with gynecological cancer and finds a low utilization of palliative care, as well as common use of chemotherapy towards the end of life. Early referral to palliative care may be an important step towards improving end-of-life care.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Oncology
Taeko Miyagi, Satoshi Miyata, Keita Tagami, Yusuke Hiratsuka, Mamiko Sato, Ikuo Takeda, Katsura Kohata, Noriaki Satake, Hiroaki Shimokawa, Akira Inoue
Summary: The study aimed to develop a simple prognostic model for predicting survival of patients with advanced cancer based on routine blood test data alone. Significant risk factors for mortality were identified through regression analyses, and patients were classified into low, medium, and high-mortality risk groups based on their score, with corresponding median survival times. The new risk model showed higher diagnostic accuracy compared to existing tools.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Multidisciplinary Sciences
Kotaro Shimura, Seiji Mabuchi, Naoko Komura, Eriko Yokoi, Katsumi Kozasa, Tomoyuki Sasano, Mahiru Kawano, Yuri Matsumoto, Tadashi Watabe, Michiko Kodama, Kae Hashimoto, Kenjiro Sawada, Jun Hatazawa, Tadashi Kimura
Summary: Increased bone marrow FDG-uptake, represented by BAR, is associated with poor prognosis in patients with gynecological cancer. The mechanism involves tumor-derived G-CSF leading to increased BM FDG-uptake and immune suppression by G-CSF-induced MDSCs, contributing to the poor prognosis of this cancer type.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Livia Costa de Oliveira, Karla Santos da Costa Rosa, Alessandra Zanei Borsatto, Luciana Aparecida Faria de Oliveira, Renata de Freitas, Simone Garruth dos Santos Machado Sampaio
Summary: This study described the overall survival in 90 days of patients with advanced cancer and COVID-19, and identified age, lung tumors, and chronic obstructive pulmonary disease as independent prognostic factors associated with higher risk of death.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Medicine, General & Internal
Stephanie Deeb, Fumiko L. Chino, Lisa C. Diamond, Anna Tao, Abraham Aragones, Armin Shahrokni, Divya Yerramilli, Erin F. Gillespie, C. Jillian Tsai
Summary: This study found that patients with metastatic cancer from racial and ethnic minority groups and those with Medicare or Medicaid coverage were more likely to receive low-value, aggressive interventions at the end of life. Further studies are needed to evaluate the underlying factors associated with end-of-life disparities and implement prospective interventions.
Article
Oncology
Yong Liu, Yin Shen, Qinghua Pan, Huasheng He, Houwen Zou, Zuochao Huang, Zhiping Liu, Xiaomao Wang
Summary: This study aimed to investigate the effectiveness of interdisciplinary collaborative hospice care (ICHC) on terminal geriatric cancer patients (TGCP) and compare it with life-sustaining treatment (LST) in terms of emotional function, symptom improvement, and cost. The results showed that ICHC had better treatment outcomes, lower medication costs, and higher patient satisfaction.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Kenta Kasahara, Masanobu Enomoto, Ryutaro Udo, Tomoya Tago, Junichi Mazaki, Tetsuo Ishizaki, Tesshi Yamada, Yuichi Nagakawa, Kenji Katsumata, Akihiko Tsuchida
Summary: This study investigated the prognostic value of preoperative high-sensitivity mGPS (HS-GPS) in patients with colon cancer. It found that HS-GPS is useful for predicting the prognosis of resectable advanced colon cancer. However, GPS may be more effective than HS-GPS as a prognostic model for advanced colon cancer.
Review
Oncology
Patrick Stone, Nicola White, Linda J. M. Oostendorp, Henry Llewellyn, Victoria Vickerstaff
Summary: A systematic review compared the prognostic tools PaP and CPS in patients with advanced cancer, finding that both were equally accurate in predicting survival probabilities. Total PaP scores showed good discrimination in predicting patients' length of survival, indicating potential utility in clinical practice but requiring further definition of its role.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Shigeaki Tsuruta, Yasutomo Goto, Hideo Miyake, Hidemasa Nagai, Yuichiro Yoshioka, Norihiro Yuasa, Junichi Takamizawa
SUPPORTIVE CARE IN CANCER
(2020)
Article
Surgery
Hironori Mizuno, Hideo Miyake, Hidemasa Nagai, Yuichiro Yoshioka, Koji Shibata, Soichiro Asai, Junichi Takamizawa, Norihiro Yuasa
Summary: This study aimed to identify the optimal cutoff values of preoperative serum CEA and CA19-9 for prognosis in stage II/III colon cancer patients. Results showed that both CEA and CA19-9 cutoff values of 5.4 ng/mL and 22.4 U/mL were significant independent factors for relapse-free survival (RFS), allowing for further relapse risk stratification.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Article
Oncology
Mari Tanaka, Natsuko Kawai, Norihiro Yuasa
Summary: This study developed a scoring system using laboratory indices to predict 14-day survival in patients with respiratory malignancy. Eight independent prognostic factors were identified and used to calculate the Respiratory Malignancy Laboratory Prognostic Score (R-LPS). The R-LPS showed acceptable accuracy in predicting 14-day mortality in terminally ill patients with respiratory malignancy.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Hidemasa Nagai, Natsuko Kawai, Norihiro Yuasa
Summary: A study developed a scoring system for short-term survival of 816 terminally ill patients with GI malignancy, showing that GI-LPS has acceptable accuracy in predicting 14-day survival.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Gastroenterology & Hepatology
Yuki Meda, Hideo Miyake, Hidemasa Nagai, Yuichiro Yoshioka, Norihiro Yuasa, Ayami Kiriyama, Masahiko Fujino
Summary: This study reports a case of SMARCA4-deficient rectal carcinoma with a sarcomatoid component. The histopathology of the tumor was similar to carcinosarcoma, but immunohistochemistry showed a deficiency of SMARCA4.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Koyo Ikeda, Hidemasa Nagai, Hideo Miyake, Yuichiro Yoshioka, Mika Katayama, Norihiro Yuasa, Takahiro Marukawa, Masafumi Ito, Masahiko Fujino, Hideki Murakami, Ayami Kiriyama
Summary: This article reports a case of well-differentiated adenocarcinoma in the stomach. The initial biopsy showed regenerative atypia, but subsequent biopsy revealed the presence of adenocarcinoma. The surgery revealed a widespread lesion that required a total gastrectomy.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Takuya Arakawa, Hideo Miyake, Hidemasa Nagai, Yuichiro Yoshioka, Koji Shibata, Daigoro Takahashi, Norihiro Yuasa, Hajime Sumi, Kanae Yoshikawa, Ayami Kiriyama, Masahiko Fujino
Summary: A 78-year-old man presented with loss of appetite and epigastric discomfort. CT and endoscopic ultrasonography revealed dilation of the main pancreatic duct and cystic lesions, leading to a diagnosis of intra-ductal papillary mucinous neoplasm (IPMN). However, ten months after surgery, recurrence was suspected and the diagnosis was changed to invasive ductal carcinoma.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Akihiro Sekimoto, Hideo Miyake, Hidemasa Nagai, Yuichiro Yoshioka, Norihiro Yuasa
Summary: Preoperative pulmonary function is related to postoperative complications and survival in gastric cancer patients undergoing gastrectomy. Patients with FEV1% < 70% are more likely to develop severe postoperative complications, while %VC < 80% is associated with decreased overall survival.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Risako Tanaka, Yuichro Yoshioka, Hideo Miyake, Hidemasa Nagai, Norihiro Yuasa, Masahiko Fujino
Summary: An 81-year-old Japanese woman was diagnosed with early gastric cancer coexisting with multiple hyperplastic polyps, which were found to be mucosal adenocarcinoma and hyperplastic through histopathological examination after distal gastrectomy. The coexistence of these lesions suggests a potential hyperplasia-carcinoma sequence related to Helicobacter pylori infection.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Surgery
Shigeaki Tsuruta, Hideo Miyake, Hidemasa Nagai, Yuichiro Yoshioka, Norihiro Yuasa, Masahiko Fujino
Summary: De Garengeot hernia is a rare disease with low incidence, often associated with appendiceal diseases. Preoperative diagnosis is challenging, requiring precise diagnosis and consideration of surgical management based on the severity of the disease.
SURGICAL CASE REPORTS
(2021)
Article
Gastroenterology & Hepatology
Sumire Kobayashi, Kota Sugiura, Hideo Miyake, Norihiro Yuasa, Kanae Yoshikawa, Masahiko Fujino
Summary: This case study describes a rare presentation of an inflammatory polyp that protruded from the appendiceal orifice, mimicking an appendiceal neoplasm, in a patient with appendiceal diverticulitis. The histopathological examination revealed features of both appendiceal diverticulitis and an inflammatory polyp resembling an MPS lesion. This case highlights the importance of considering rare differential diagnoses in patients with unusual clinical presentations.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Aika Matsushita, Norihiro Yuasa, Hideo Miyake, Hidemasa Nagai, Takuya Nagao, Masahiko Fujino
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2020)