Pharmacodynamic evaluation of meropenem, cefepime, or aztreonam combined with a novel β-lactamase inhibitor, nacubactam, against carbapenem-resistant and/or carbapenemase-producing Klebsiella pneumoniae and Escherichia coli using a murine thigh-infection model

In Vivo Activity of WCK 4282 (High-Dose Cefepime/Tazobactam) against Serine-β-lactamase-Producing Enterobacterales and Pseudomonas aeruginosa in the Neutropenic Murine Lung Infection Model

(2021) Maxwell J. LASKO et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Safety and Pharmacokinetic Characterization of Nacubactam, a Novel β-Lactamase Inhibitor, Alone and in Combination with Meropenem, in Healthy Volunteers

(2020) Navita L. Mallalieu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study

(2020) David van Duin et al.   LANCET INFECTIOUS DISEASES

In vivo study assessed meropenem and amikacin combination therapy against carbapenem-resistant and carbapenemase-producing Enterobacteriaceae strains

(2019) Mao Hagihara et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

An update on β-lactamase inhibitor discovery and development

(2018) Jean-Denis Docquier et al.   DRUG RESISTANCE UPDATES

The epidemiology and risk factor of carbapenem-resistant enterobacteriaceae colonization and infections: Case control study in a single institute in Japan

(2018) Nobuhiro Asai et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Activity of nacubactam (RG6080/OP0595) combinations against MBL-producing Enterobacteriaceae

(2018) Shazad Mushtaq et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Prevalence of, and risk factors for, carriage of carbapenem-resistant Enterobacteriaceae among hospitalized patients in Japan

(2017) N. Yamamoto et al.   JOURNAL OF HOSPITAL INFECTION

Evaluation of commercial phenotypic assays for the detection of IMP- or New Delhi metallo-β-lactamase-producing Enterobacteriaceae isolates in Japan

(2017) Daisuke Sakanashi et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace

(2017) Latania K. Logan et al.   JOURNAL OF INFECTIOUS DISEASES

Interactions of OP0595, a Novel Triple-Action Diazabicyclooctane, with β-Lactams against OP0595-Resistant Enterobacteriaceae Mutants

(2015) David M. Livermore et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activity of OP0595/β-lactam combinations against Gram-negative bacteria with extended-spectrum, AmpC and carbapenem-hydrolysing β-lactamases

(2015) David M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

OP0595, a new diazabicyclooctane: mode of action as a serine β-lactamase inhibitor, antibiotic and β-lactam ‘enhancer’

(2015) Akihiro Morinaka et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Efficacy of doripenem and ertapenem against KPC-2-producing and non-KPC-producing Klebsiella pneumoniae with similar MICs

(2013) M. Hagihara et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Detection of IMP Metallo- -Lactamase in Carbapenem-Nonsusceptible Enterobacteriaceae and Non-Glucose-Fermenting Gram-Negative Rods by Immunochromatography Assay

(2013) S. Notake et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Treatment Outcome of Bacteremia Due to KPC-Producing Klebsiella pneumoniae: Superiority of Combination Antimicrobial Regimens

(2012) Zubair A. Qureshi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Predictors of Mortality in Bloodstream Infections Caused by Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae: Importance of Combination Therapy

(2012) M. Tumbarello et al.   CLINICAL INFECTIOUS DISEASES

Multidrug resistance determinants from NDM-1-producing Klebsiella pneumoniae in the USA

(2012) Tomasz Leski et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Evolution of IncA/CblaCMY-2-Carrying Plasmids by Acquisition of theblaNDM-1Carbapenemase Gene

(2011) Alessandra Carattoli et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Novel Variant, NDM-5, of the New Delhi Metallo-β-Lactamase in a Multidrug-Resistant Escherichia coli ST648 Isolate Recovered from a Patient in the United Kingdom

(2011) Michael Hornsey et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study

(2010) Karthikeyan K Kumarasamy et al.   LANCET INFECTIOUS DISEASES

Characterization and Sequence Analysis of Extended-Spectrum- -Lactamase-Encoding Genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis Isolates Collected during Tigecycline Phase 3 Clinical Trials

(2008) C. H. Jones et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY