Journal
IEEE PHOTONICS TECHNOLOGY LETTERS
Volume 33, Issue 10, Pages 495-498Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/LPT.2021.3071970
Keywords
Microcavities; Biosensors; Optical fiber theory; Refractive index; Optical fiber sensors; Optical fiber networks; Optical fiber couplers; BSA concentration detection; fiber-optic biosensor; microfabrication
Funding
- Natural Science Foundation of Tianjin [18JCQNJC71300]
- National Natural Science Foundation of China [11804250, 11904262, 61875091, 11904180, 11004110]
- Tianjin Education Commission Scientific Research Project [2019KJ016, 2018KJ146]
- Tianjin Research Innovation Project for Postgraduate Students [2020YJSS015]
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The compact and label-free biosensor based on coreless-fiber-coupled microcavity is proposed for bovine serum albumin (BSA) detection, showing high sensitivity and clear differentiation of samples. It is suitable for detecting low-concentration micro-samples analytes in the fields of life sciences, biological engineering, and biopharmaceutical industry.
A compact and label-free biosensor based on coreless-fiber-coupled microcavity is proposed and experimentally demonstrated for bovine serum albumin (BSA) detection. The microcavity is fabricated in a coreless fiber by on-line fiber cutting-welding micromachining. Experimental results show that the BSA samples with different concentration and refractive index ranging from 1.3344 to 1.3349 are clearly discriminated by spectral characteristics of the coreless-fiber-coupled microcavity, with a sensitivity of 1.602 nm/(mg/ml). The device presents superiorities such as miniature size, standardized production control, reliable quality, and cost effective, which makes it a good candidate for the detection of low-concentration micro-samples analytes in the fields of life sciences, biological engineering, and biopharmaceutical industry.
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