Review
Biochemistry & Molecular Biology
Mara Simopoulou, Anna Rapani, Sokratis Grigoriadis, Agni Pantou, Petroula Tsioulou, Evangelos Maziotis, Despina Tzanakaki, Olga Triantafyllidou, Theodoros Kalampokas, Charalampos Siristatidis, Panagiotis Bakas, Nikolaos Vlahos
Summary: The article discusses the infertility associated with endometriosis, highlighting the various pathological mechanisms that contribute to impaired reproductive dynamics. Reactive oxygen species, immune system dysregulation, and cellular architectural disruption are key mechanisms affecting oocyte and embryo development potential in endometriosis patients.
Article
Obstetrics & Gynecology
Dalila Invernici, Marco Reschini, Laura Benaglia, Edgardo Somigliana, Giulia Galati, Irene La Vecchia, Paola Vigano', Paolo Vercellini
Summary: This study found that endometriosis does not significantly affect the success of IVF, except for an increased risk of unexpected poor response.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Endocrinology & Metabolism
Edgardo Somigliana, Letizia Li Piani, Alessio Paffoni, Noemi Salmeri, Michele Orsi, Laura Benaglia, Paolo Vercellini, Paola Vigano'
Summary: Apart from the negative effect of surgical excision of endometriomas on ovarian reserve, endometriosis does not significantly affect IVF outcomes. Ovarian response, oocyte quality, and embryonic development remain largely unaffected.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Houjin Dongye, Yizheng Tian, Dan Qi, Yanbo Du, Lei Yan
Summary: The influence of endometrioma on oocyte and embryo competence is inconclusive, and the benefits of surgical treatment remain uncertain. This study aimed to investigate the effect of endometrioma on oocyte and embryo quality from a morphological perspective and explore whether surgery could improve oocyte and embryo competence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Yaoxue Yin, Yundong Mao, Anthony Liu, Li Shu, Chun Yuan, Yugui Cui, Zhen Hou, Jiayin Liu
Summary: The study revealed that the insufficient cumulus expansion in women with EMs-related infertility may explain the difficulty in oocyte retrieval during assisted reproductive technology.
REPRODUCTIVE SCIENCES
(2021)
Article
Medicine, General & Internal
Maria Manuel Casteleiro Alves, Luisa Oliani, Micaela Almeida, Henrique Jose Cardoso, Antonio Helio Oliani, Luiza Breitenfeld, Ana Cristina Ramalhinho
Summary: This study analyzed the levels of cfDNA in follicular fluid samples from infertile women. The results showed that the concentration of cfDNA was significantly higher in women aged 35 and over, as well as in women with associated female factors. In addition, higher levels of cfDNA were found in follicular fluid with embryos of high fragmentation rate and in women who did not become pregnant during IVF treatments. Therefore, the quantification of cfDNA could be an important biomarker to predict embryo quality and the success of IVF.
Article
Medicine, General & Internal
Carlotta Scarafia, Martina Masciovecchio, Stefano Canosa, Andrea Roberto Carosso, Gianluca Gennarelli, Alberto Revelli, Chiara Benedetto
Summary: The study found that in women with ovarian endometriosis, ICSI can be performed without harming oocytes or affecting the outcome. Additionally, there is no advantage in removing endometrioma before ICSI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yang-Ching Chen, Yen-Chia Yeh, Yu-Fang Lin, Heng-Kien Au, Shih-Min Hsia, Yue-Hwa Chen, Rong-Hong Hsieh
Summary: Frequent consumption of diet drinks, specifically those with aspartame, is associated with negative effects on fertility, including oocyte dysmorphism and decreased embryo quality. Aspartame consumption leads to disrupted estrus cycle, reduced anti-Mullerian hormone level, increased oxidative stress in the ovaries, and decline in mitochondrial function, which affects follicle preservation and steroidogenesis in granulosa cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Isotta M. Magaton, Anja Helmer, Markus Eisenhut, Marie Roumet, Petra Stute, Michael von Wolff
Summary: High-dose gonadotrophin stimulation affects oocyte and early-stage embryo development. The study found that natural cycle IVF (NC-IVF) had higher rates of mature oocytes and fertilized zygotes compared to conventional IVF (cIVF). In addition, the morphology of the cleavage-stage embryo was also improved in NC-IVF.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Review
Endocrinology & Metabolism
Tarique Hussain, Mahmoud Kandeel, Elsayed Metwally, Ghulam Murtaza, Dildar Hussain Kalhoro, Yulong Yin, Bie Tan, Muhammad Ismail Chughtai, Anjaleena Yaseen, Ali Afzal, Muhammad Saleem Kalhoro
Summary: Male infertility is a global issue with oxidative stress being the main contributing factor, affecting sperm quality and quantity. Dysfunction of mitochondria and inflammation also play important roles in compromised fertility. The interaction between oxidative stress and seminal plasma proteomes further influences male infertility. Understanding these factors can help improve strategies to prevent male infertility.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Tahir Muhammad, Yanling Wan, Yue Lv, Hanzhen Li, Wasifa Naushad, Wai-Yee Chan, Gang Lu, Zi-Jiang Chen, Hongbin Liu
Summary: Currently, obesity in reproductive-aged women has reached an epidemic level, leading to various consequences. It has been found that obesity can cause reproductive complications, particularly affecting fertility rates. These complications arise from the poor quality of oocytes in obese mothers, which results in increased chances of chromosomal abnormalities, high production of reactive oxygen species, impaired embryonic development, and ultimately reduced fertility. Maternal obesity is also associated with pregnancy complications such as implantation errors, abortion, miscarriage, and early pregnancy loss. This review emphasizes the negative effects of maternal obesity on female fertility, focusing on the mechanistic link between maternal obesity and oocyte quality, and proposing possible measures to reduce associated risks.
Article
Endocrinology & Metabolism
Camille Robin, Audrey Uk, Christine Decanter, Helene Behal, Pierre Collinet, Chrystele Rubod, Anne-Laure Barbotin, Geoffroy Robin
Summary: The study aimed to evaluate the relationship between endometriosis and oocyte morphology after controlled ovarian stimulation for intracytoplasmic sperm injection (ICSI) on a large oocyte cohort, finding that endometriosis does not have a negative impact on oocytes' morphology in IVF-ICSI.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Houjin Dongye, Xiaofeng Ji, Xiaopei Ma, Jialun Song, Lei Yan
Summary: The study found no significant association between endometriosis and embryo quality, with no differences observed in high-quality embryo rate, cleavage rate, and embryo formation rate in overall analysis as well as subgroup analyses based on the severity of endometriosis or ovarian cysts.
FRONTIERS IN MEDICINE
(2021)
Article
Obstetrics & Gynecology
Caroline M. Da Luz, Michele G. Da Broi, Jessica R. Placa, Wilson A. Silva Jr, Juliana Meola, Paula A. Navarro
Summary: The transcriptome of cumulus cells is altered in infertile women with advanced endometriosis, regardless of the presence of endometrioma. Differentially expressed genes in cumulus cells of endometriosis patients are involved in important pathways for oocyte competence acquisition, such as oxidative phosphorylation, metabolism, mitochondrial function, acetylation, and steroid biosynthesis. Comparing cumulus cells from women with advanced endometriosis with and without endometrioma did not show any differentially expressed genes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Review
Biochemistry & Molecular Biology
Konstantinos Sfakianoudis, Evangelos Maziotis, Eleni Karantzali, Georgia Kokkini, Sokratis Grigoriadis, Amelia Pantou, Polina Giannelou, Konstantina Petroutsou, Christina Markomichali, Maria Fakiridou, Michael Koutsilieris, Byron Asimakopoulos, Konstantinos Pantos, Mara Simopoulou
Summary: Developmental arrest of the preimplantation embryo is a multifactorial condition involving embryonic and parental factors, with genetic origins analyzed from both perspectives. This systematic review provides valuable insights into the molecular drivers of developmental arrest, laying the groundwork for further research in the field. The variety and complexity of factors contributing to developmental arrest make it difficult to prioritize one definitive cause.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Maria Cristina Carbajo-Garcia, Zaira Garcia-Alcazar, Ana Corachan, Javier Monleon, Alexandra Trelis, Amparo Faus, Antonio Pellicer, Hortensia Ferrero
Summary: The study demonstrates that SAHA inhibits cell proliferation, cell cycle, ECM formation, and TGF-/53 signaling in human uterine leiomyoma primary cells, suggesting the potential utility of histone deacetylase inhibition in the treatment of uterine leiomyoma.
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Marina Segura-Benitez, Maria Cristina Carbajo-Garcia, Ana Corachan, Amparo Faus, Antonio Pellicer, Hortensia Ferrero
Summary: Successful implantation relies on communication between maternal endometrium and embryo, with EVs playing a role in this process. Ultracentrifugation was found to be the most efficient method for EV isolation from endometrial epithelial cells, with EVs containing proteins related to embryo implantation processes.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Emilio Frances-Herrero, Adolfo Rodriguez-Eguren, Maria Gomez-Alvarez, Lucia de Miguel-Gomez, Hortensia Ferrero, Irene Cervello
Summary: Bioengineering and reproductive medicine have progressed together, focusing on the development and clinical translation of technologies to support reproductive health, such as hydrogels. This literature review highlights the recent advances in using organ-specific ECM hydrogels in reproductive medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Elena Juarez-Barber, Mauro Cozzolino, Ana Corachan, Diana Alecsandru, Nuria Pellicer, Antonio Pellicer, Hortensia Ferrero
Summary: This study investigated the endometrial receptivity of patients with adenomyosis and the impact of personalized embryo transfer (PET) on IVF outcomes. The results showed that patients with adenomyosis had altered endometrial receptivity, but PET did not significantly improve reproductive outcomes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Review
Biochemistry & Molecular Biology
Adolfo Rodriguez-Eguren, Maria Gomez-alvarez, Emilio Frances-Herrero, Monica Romeu, Hortensia Ferrero, Emre Seli, Irene Cervello
Summary: This literature review analyzes the application of human umbilical cord mesenchymal stem cells (hUC-MSCs) and blood derivatives in the treatment of female infertility. It shows that these alternative therapies have high efficacy in promoting anti-inflammatory and regenerative processes. However, further clinical trials are needed to validate their application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Elena Juarez-Barber, Marina Segura-Benitez, Maria Cristina Carbajo-Garcia, Alba Bas-Rivas, Amparo Faus, Carmen Vidal, Juan Giles, Elena Labarta, Antonio Pellicer, Irene Cervello, Hortensia Ferrero
Summary: This study analyzed the miRNAs present in extracellular vesicles secreted by the endometrium of women with adenomyosis. The results showed that these vesicles contain miRNAs related to adenomyosis, implantation failure, and pregnancy complications. The miRNAs regulate downstream genes involved in adenomyosis progression and impaired embryo implantation.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Engineering, Biomedical
Maria Gomez-alvarez, Clara Bueno-Fernandez, Adolfo Rodriguez-Eguren, Emilio Frances-Herrero, Marcos Agustina-Hernandez, Amparo Faus, Fernando Gisbert Roca, Cristina Martinez-Ramos, Amparo Galan, Antonio Pellicer, Hortensia Ferrero, Irene Cervello
Summary: The endometrium plays a vital role in fertility and understanding its physiology is crucial for improving reproductive healthcare. This study presents a hybrid endometrial-derived hydrogel that shows promising potential as a biomaterial for regenerative treatments in reproductive medicine. The hydrogel provides excellent support for hEO culture, enhances hEO differentiation efficiency, and demonstrates in vivo compatibility and stability.
ADVANCED HEALTHCARE MATERIALS
(2023)
Meeting Abstract
Obstetrics & Gynecology
Marina Segura-Benitez, Alba Bas-Rivas, Elena Juarez-Barber, Maria Cristina Carbajo-Garcia, Amparo Faus, Antonio Pellicer, Hortensia Ferrero
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Ana Corachan, Maria Victoria Victoria Bariani, Qiwei Yang, Tao Bai, Hortensia Ferrero, Ayman Al-Hendy
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Mauro Cozzolino, Elena Juarez-Barber, Ana Corachan, Diana Alecsandru, Antonio Pellicer, Hortensia Ferrero
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Elena Juarez-Barber, Marina Segura-Benitez, Maria Cristina Carbajo-Garcia, Alba Bas-Rivas, Amparo Faus, Antonio Pellicer, Hortensia Ferrero
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Elena Juarez-Barber, Ana Corachan, Emilio Frances-Herrero, Carmina Vidal, Juan Giles, Pilar Alama, Amparo Faus, Antonio Pellicer, Irene Cervello, Hortensia Ferrero
REPRODUCTIVE SCIENCES
(2022)
Meeting Abstract
Obstetrics & Gynecology
Maria Cristina Carbajo-Garcia, Alexandra Trelis, Javier Monleon, Antonio Pellicer, James M. Flanagan, Hortensia Ferrero
REPRODUCTIVE SCIENCES
(2022)