Journal
BRAIN RESEARCH
Volume 1608, Issue -, Pages 1-13Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2015.02.051
Keywords
Brain; Mechanically-gated; Cation channels; Triggered; Action potentials
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Funding
- University of Newcastle
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The mammalian brain is a mechanosensitive organ that responds to different mechanical forces ranging from intrinsic forces implicated in brain morphogenesis to extrinsic forces that can cause concussion and traumatic brain injury. However, little is known of the mechanosensors that transduce these forces. In this study we use cell-attached patch recording to measure single mechanically-gated (MG) channel currents and their affects on spike activity in identified neurons in neonatal mouse brain slices. We demonstrate that both neocortical and hippocampal pyramidal neurons express stretch-activated MG cation channels that are activated by suctions of similar to 25 mm Hg, have a single channel conductance for inward current of 50-70 PS and show weak selectivity for alkali metal cations (i.e., Na+
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