Journal
BRAIN RESEARCH
Volume 1599, Issue -, Pages 57-66Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2014.12.039
Keywords
Radial glial cell; Glial branch; Neuronal migration; In utero electroporation
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Funding
- Foundation for Special Talent of NWSUAF [Z111021101]
- National Natural Science Foundation of China [31071873, 30972151]
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During brain development, the radial glial cell acts as a scaffold to support radial migration of postmitotic neurons. However, the morphological changes of radial glial cells during embryo development are poorly understood. We used in utero electroporation and immunohistochemistry to study the dynamics of radial glial cells accompanied by cortical development in mice from embryonic day 14 to postnatal day 0. We found that different segments of radial glial cells changed by the growth of different layers of cortex, such as marginal zone, cortical plate, intermediate zone and ventricular zone. Moreover, the length, angle and number of branches of the radial glial cell changed significantly at the late stage of neurogenesis. All these changes were consistent with the distinct phases of locomotion. Thus, we speculated that morphological changes of the radial glial cell were associated with the neuronal migration and dendritic development. (C) 2014 Elsevier B.V. All rights reserved.
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