Review
Medicine, General & Internal
Mariam H. Mella, Emilien Chabrillac, Agnes Dupret-Bories, Mathilde Mirallie, Sebastien Vergez
Summary: Minimally invasive surgery, specifically transoral robotic surgery (TORS), has become popular in the field of surgical oncology for the treatment of head and neck cancer. TORS utilizes wristed instruments and a magnified three-dimensional view for enhanced surgical comfort and safety in hard-to-access areas. However, the expansion of TORS must be based on high-level evidence to ensure comparable oncological outcomes to traditional approaches. This narrative review evaluates the current role of TORS in head and neck cancer treatment and identifies remaining knowledge gaps.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Otorhinolaryngology
Louis-Xavier Barrette, Emma De Ravin, Ryan M. Carey, Leila J. Mady, Steven B. Cannady, Robert M. Brody
Summary: This study conducted a systematic review on reconstructive modalities and postoperative surgical outcomes following TORS resection. The most commonly performed reconstruction was the radial forearm free flap, and the surgical outcomes were favorable but lacked quantitative functional data for comparing reconstructive options following TORS.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Melissa Henry, Elyonora Sargi, Saul Frenkiel, Michael Hier, Anthony Zeitouni, Karen Kost, Alex Mlynarek, Martin Black, Christina MacDonald, Keith Richardson, Gabrielle Chartier, Nader Sadeghi, Zeev Rosberger
Summary: The study revealed that 25% of patients diagnosed with first occurrence of head and neck cancer had a lifetime anxiety disorder, with 19.4% developing it within 2 weeks of diagnosis and 16.6% immediately post-treatment; accounting for 26.7% of patients with anxiety disorder at any timepoint. Multiple anxiety disorder trajectories can arise from diagnosis to post-treatment in primary head and neck cancer patients.
Review
Oncology
Lachlan McDowell, Danny Rischin, Karla Gough, Christina Henson
Summary: Head and neck squamous cell carcinoma (HNSCC) is a common cancer with various risk factors. The treatment of HNSCC can cause significant side effects, and age is considered in treatment recommendations. However, there is limited evidence of vulnerability in older patients with HNSCC.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Amit Ritter, Helena Levyn, Jatin Shah
Summary: The field of head and neck oncology has undergone remarkable advancements in recent years, with innovative surgical approaches and personalized treatment strategies, leading to improved patient outcomes.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Clinical Neurology
Jan Prasko, Jakub Vanek, Marie Ociskova, Kamila Belohradova, Michaela Holubova, Krystof Kantor, Milos Slepecky, Tomas Sollar
Summary: Multiple sclerosis is an autoimmune disease that can cause a variety of physical symptoms, as well as behavioral and psychiatric symptoms. These symptoms can have a significant impact on a patient's quality of life and may be influenced by their personality traits and coping abilities. Meeting the needs of MS patients can be challenging, especially in areas such as lifestyle, work, social environment, and relationships. It can also be difficult to distinguish between symptoms caused by MS, psychiatric disorders, unmet psychosocial needs, or the side effects of treatment.
ACTIVITAS NERVOSA SUPERIOR REDIVIVA
(2022)
Article
Oncology
Renee Eggins, Helen Fowler, Jessica Cameron, Joanne F. Aitken, Philippa Youl, Gavin Turrell, Suzanne K. Chambers, Jeff Dunn, Chris Pyke, Peter D. Baade, Belinda Goodwin
Summary: The objective of this study was to investigate whether supportive care needs vary based on remoteness and area-level socio-economic status, and to identify the factors associated with lower quality of life, higher psychological distress, and severity of unmet supportive care needs. The results showed that women living in outer regional areas reported the highest severity of unmet need, and those in moderately and most disadvantaged areas also had greater unmet need. Three clusters of women were identified based on their characteristics and differences in unmet needs and psychosocial outcomes. This information can be used to identify women with higher supportive care needs and target interventions accordingly.
Article
Oncology
Chikatoshi Katada, Manabu Muto, Satoshi Fujii, Tetsuji Yokoyama, Tomonori Yano, Akihito Watanabe, Toshiro Iizuka, Shigetaka Yoshinaga, Ichiro Tateya, Hiroki Mitani, Yuichi Shimizu, Akiko Takahashi, Tomoyuki Kamijo, Noboru Hanaoka, Makoto Abe, Akihiro Shiotani, Koichi Kano, Yukinori Asada, Tamotsu Matsuhashi, Hirohito Umeno, Kenji Okami, Kenichi Goda, Shinichiro Hori, Yoichiro Ono, Shuji Terai, Yasuaki Nagami, Kenichi Takemura, Kenro Kawada, Mizuo Ando, Naoto Shimeno, Akihito Arai, Yasutoshi Sakamoto, Masaaki Ichinoe, Tetsuo Nemoto, Masahiro Fujita, Hidenobu Watanabe, Tadakazu Shimoda, Atsushi Ochiai, Takakuni Kato, Ryuichi Hayashi
Summary: The study examined the safety and efficacy of transoral surgery for superficial head and neck cancer, finding that the procedure was effective with relatively low incidence of adverse events and no treatment-related deaths, indicating it as an effective minimally invasive treatment option.
Article
Oncology
Evelinn A. Borrayo, Elizabeth Juarez-Colunga, Kristin Kilbourn, Jeanette Waxmonsky, Marty Jacobson, Sonia Okuyama, Robert Swaney, Frederick S. Wamboldt, Sana Karam, Samantha Lopez Alvarez, Xin Jin, Jennifer Nguyen
Summary: This comparative effectiveness study examined the impact of a stepped-care intervention on mental health outcomes in patients with lung cancer and head-and-neck cancer. The findings showed that the intervention had positive effects on depression and coping self-efficacy, with no significant differences in anxiety outcomes. Additionally, emotional distress and health-related quality of life were better in patients who received the intervention, while perceived stress did not differ across groups.
Article
Oncology
Jatin P. Shah, Richard J. Wong
Summary: In the past five decades, significant technological advancements in imaging techniques and reconstructive surgery have greatly improved accurate assessment and treatment of tumors, leading to a better quality of life for patients.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Laura D. Locati, Elena Colombo, Marek Dedecjus, Christelle de la Fouchardiere, Ward Sents, Massimo Bongiovanni, Romana Netea-Maier
Summary: Anaplastic thyroid carcinoma (ATC) is a rare and deadly cancer, and there are challenges in prescribing novel treatments in Europe as they haven't been licensed for ATC yet. Patients manage to receive these drugs through alternative ways. An investigation showed disparities in access to new treatments, and it emphasized the urgent need for access to cutting-edge therapies and the feasibility of clinical trials.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Medicine, General & Internal
Alexander Gormley, Charlotte Richards, Francesca Spiga, Emily Gray, Joanna Hooper, Barry Main, Emma E. Vincent, Rebecca Richmond, Julian Higgins, Mark Gormley
Summary: Head and neck cancer squamous cell carcinoma (HNSCC) is the sixth most common cancer globally, with established risk factors including smoking, alcohol, and HPV infection. In addition to HPV, obesity and T2D may also play a role in the rising incidence rates.
Article
Oncology
Laura Warner, James T. O'Hara, Daniel J. Lin, Nashreen Oozeer, Hannah Fox, David Meikle, David Hamilton, Muhammad Shahid Iqbal, Max Robinson, Vinidh Paleri
Summary: This study reports the oncological outcomes and analyzes the influence of resection margins on local recurrence rates in head and neck squamous cell carcinoma patients treated with transoral robotic surgery and neck dissection. The presence of a positive margin on the resected specimen was found to be the strongest predictor of local recurrence.
Article
Oncology
Yolanda Andreu, Paula Martinez, Ana Soto-Rubio, Silvia Fernandez, Carles Bosch, Andres Cervantes
Summary: This study aimed to determine the prevalence of distress and unmet supportive care needs in post-treatment colorectal cancer (CRC) survivors. Findings showed that one in five CRC survivors had clinical distress and 86% expressed at least one unmet need. The risk factors associated with this included lower socioeconomic status, younger age, and a primary treatment that includes more than surgery.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Psychiatry
Laura Inhestern, Lene Marie Johannsen, Corinna Bergelt
Summary: Cancer in parents with minor children presents significant challenges, requiring a deeper understanding of the impact on children, family quality of life levels, and parental psychosocial needs to develop appropriate interventions. The study found that parental cancer can have both positive and negative effects on children, while parents express specific family-related psychosocial support needs.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Medicine, Research & Experimental
Leandro L. Matos, Alvaro Sanabria, K. Thomas Robbins, Gyorgy B. Halmos, Primoz Strojan, Wai Tong Ng, Robert P. Takes, Peter Angelos, Cesare Piazza, Remco de Bree, Ohad Ronen, Orlando Guntinas-Lichius, Avraham Eisbruch, Mark Zafereo, Antti A. Makitie, Ashok R. Shaha, Andres Coca-Pelaz, Alessandra Rinaldo, Nabil F. Saba, Oded Cohen, Fernando Lopez, Juan P. Rodrigo, Carl E. Silver, Timo E. Strandberg, Luiz Paulo Kowalski, Alfio Ferlito
Summary: The projected increase in life expectancy is expected to lead to a rise in age-related diseases, including cancer. This report critically reviews the literature on managing older patients with head and neck cancer (HNC). Older adults, especially those who are frail or have comorbidities, are more prone to complications and toxicities from HNC treatment. Screening older patients for predispositions and managing comorbidities is essential. Age alone should not be a determining factor for less intensive treatment, and older patients should be treated according to the best standard of care to avoid increased treatment failure rates and mortality. A multidisciplinary tumor board should establish the treatment plan, involving shared decision-making with patients and family, and treatment modifications should be considered for patients with severe comorbidities, frailty, or who refuse recommendations.
ADVANCES IN THERAPY
(2023)
Article
Otorhinolaryngology
Johanna Westermann-Lammers, Jawad Salameh, Christian Dobel, Orlando Guntinas-Lichius
Summary: A pilot study was conducted on 25 normal hearing young adults to investigate the effect of simulated acute hearing loss on static balance function. The study found that simulated moderate to severe bilateral conductive hearing loss did not disturb the static balance function in normal hearing younger adults.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
S. Becker, M. Laudien, U. Foerster-Ruhrmann, H. Olze, C. Rudack, A. M. Chaker, J. Hagemann, T. Huppertz, T. K. Hoffmann, S. Dazert, T. Deitmer, S. Strieth, H. Wrede, W. Schlenter, H. J. Welkoborsky, B. Wollenberg, F. Baerhold, F. Klimek, R. Kianfar, J. Zuberbier, M. Cuevas, C. A. Hintschich, O. Guntinas-Lichius, T. Stoever, C. Bergmann, P. Werminghaus, O. M. Groeger, C. Beutner, R. K. Weber, T. Hildenbrand, A. S. Hoffmann, L. Klimek
LARYNGO-RHINO-OTOLOGIE
(2023)
Article
Otorhinolaryngology
H. B. Zech, C. S. Betz, T. K. Hoffmann, J. P. Klussmann, T. Deitmer, O. Guntinas-Lichius
Summary: The ORATOR2 trial investigated therapy de-escalation in early human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OPSCC). The study compared radiotherapy with trans-oral surgery and neck dissection in 61 patients. The primary endpoint favored radiotherapy, but the trial had limitations and caution should be exercised in drawing conclusions for clinical practice.
LARYNGO-RHINO-OTOLOGIE
(2023)
Article
Otorhinolaryngology
L. Klimek, U. Foerster-Ruhrmann, H. Olze, A. G. Beule, A. M. Chaker, J. Hagemann, T. Huppertz, T. K. Hoffmann, S. Dazert, T. Deitmer, S. Strieth, H. Wrede, W. Schlenter, H. J. Welkoborsky, B. Wollenberg, S. Becker, F. Baerhold, F. Klimek, I. Casper, J. Zuberbier, C. Rudack, M. Cuevas, C. A. Hintschich, O. Guntinas-Lichius, T. Stoever, C. Bergmann, P. Werminghaus, O. Pfaar, J. Gosepath, M. Groeger, C. Beutner, M. Laudien, R. K. Weber, T. Hildenbrand, A. S. Hoffmann, C. Bachert
Summary: This study analyzed previous data on the treatment of CRSwNP with mepolizumab and provided recommendations for follow-up, therapy intervals, possible therapy pauses, and discontinuation of therapy when using mepolizumab as add-on therapy for severe CRSwNP.
LARYNGO-RHINO-OTOLOGIE
(2023)
Article
Otorhinolaryngology
H-J Welkoborsky, Thomas Deitmer, Jan Loehler, Orlando Guntinas-Lichius
Summary: The German Healthcare System is undergoing significant changes and requires appropriate intersectoral treatment structures. ENT department chairmen and ENT specialists in private practice believe that the current remuneration system needs urgent revision. Challenges include emergency care, information transfer for inpatients, and problems with continuing education of residents.
LARYNGO-RHINO-OTOLOGIE
(2023)
Editorial Material
Otorhinolaryngology
Orlando Guntinas-Lichius, Stephan Lang, Timo Stoever, Thomas K. Hoffmann, Stefan Plontke, Hans-Juergen Welkoborsky, Thomas Zahnert, Burkard M. Lippert, Nicole Rotter, S. Dazert, Andreas Dietz, Thomas Deitmer
Summary: The 2018 template for otorhinolaryngology specialist training in Germany is being implemented by the federal associations. The German Society and Professional Association of German Otorhinolaryngologists recommended a training plan for Otorhinolaryngology, Head and Neck Surgery as a guideline for the federal medical associations. The state medical associations are currently working on criteria for granting authority to otorhinolaryngologists and training institutions.
LARYNGO-RHINO-OTOLOGIE
(2023)
Article
Oncology
Mussab Kouka, Isabel Hermanns, Peter Schlattmann, Orlando Guntinas-Lichius
Summary: This population-based study in Germany found that the patient's age plays an important role in the treatment decision for head and neck cancer. Older patients are more likely to undergo surgery, radiotherapy, and chemotherapy.
Article
Oncology
Susanne Wiegand, Gunnar Wichmann, Jeannette Vogt, Kathrin Vogel, Annegret Franke, Thomas Kuhnt, Florian Lordick, Anne-Marie Scheuble, Peter Hambsch, Peter Brossart, Franz Georg Bauernfeind, Holger Kaftan, Georg Maschmeyer, Matthias Paland, Marc Muenter, Victor Lewitzki, Nicole Rotter, Carmen Stromberger, Marcus Beck, Steffen Dommerich, Thomas Christoph Gauler, Gunnar Hapke, Orlando Guntinas-Lichius, Ursula Schroeder, Martin Goerner, Matthias G. Hautmann, Felix Steger, Balint Tamaskovics, Anett Schmiedeknecht, Andreas Dietz
Summary: Most patients with head and neck squamous cell carcinoma (HNSCC) are diagnosed with locally advanced disease and can be treated with surgery and adjuvant radio(chemo)therapy or definitive chemoradiation. However, recurrence is common, especially in high-risk cases. The ADRISK trial aims to investigate whether the addition of pembrolizumab to the standard treatment improves event-free survival in locally advanced HNSCC patients. This ongoing prospective, randomized controlled trial is recruiting patients since August 2018.
FRONTIERS IN ONCOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Paolo Bossi, Cristina Gurizzan, Orlando Guntinas-Lichius, Razvan Hainarosie, Davide Lancini
Summary: This expert opinion narrative review summarized the current indicated applications of benzydamine and proposed new areas for exploration.
FRONTIERS IN ORAL HEALTH
(2023)
Article
Otorhinolaryngology
Susanna Seeberger, Peter Schlattmann, Orlando Guntinas-Lichius
Summary: This study analyzed the development of facial surgery in Germany and found a significant increase in the number and proportion of patients undergoing surgery for chronic flaccid paralysis of the facial nerve in the past decade. Nerve reconstruction surgery and static sling surgery showed the highest increase in surgery rate.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Mussab Kouka, Nils Bevern, Julia Bitter, Orlando Guntinas-Lichius
Summary: This retrospective study investigates the impact of adding N-acetylcysteine (NAC) to prednisolone treatment on patients with idiopathic sudden sensorineural hearing loss (ISSHL). The results suggest that combined treatment with prednisolone and NAC leads to better hearing recovery outcomes compared to prednisolone treatment alone.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Immunology
Nico Andreas, Katharina Geissler, Juliane Priese, Orlando Guntinas-Lichius, Thomas Kamradt
Summary: Although the role of palatine tonsils in immune protection or tolerance is still debated, their removal has consequences for the immune system. The study found that all granulocyte subsets accumulate in aging tonsils, with basophils and mast cells showing the most pronounced accumulation. The immune-regulatory phenotype of tonsilar monocytes may counteract the phenomenon of inflammaging at higher age.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Francisco Civantos, Zachary M. Helmen, Patrick J. Bradley, Andres Coca-Pelaz, Remco De Bree, Orlando Guntinas-Lichius, Luiz P. Kowalski, Fernando Lopez, Antti A. Makitie, Alessandra Rinaldo, K. Thomas Robbins, Juan P. Rodrigo, Robert P. Takes, Alfio Ferlito
Summary: Skin cancer, especially non-melanoma skin cancer, is the most common malignancy worldwide. The management of different types of skin cancer is not clearly defined in scientific literature. Some require surgical removal, but the management of regional metastasis may vary, and microscopic metastases may be undetectable. This article summarizes the current literature on managing non-melanoma skin cancer that has spread to regional lymph nodes.
Article
Oncology
Mussab Kouka, Laura Gerlach, Jens Buentzel, Holger Kaftan, Daniel Boeger, Andreas H. Mueller, Thomas Ernst, Orlando Guntinas-Lichius
Summary: The impact of HPV infection and smoking status on overall survival of OPSCC patients was investigated. HPV-positive patients had better survival, while smoking status had no independent influence on the risk of death. The majority of OPSCC cases in Thuringia were HPV-negative smokers. Optimizing therapeutic strategies for HPV-negative patients is more important.