Article
Biochemistry & Molecular Biology
Simon-Okomo Aloo, Fred-Kwame Ofosu, Deog-Hwan Oh
Summary: The study found that sprouts are healthier and more nutritionally rich than raw seeds, with stronger antioxidant, antidiabetic, and antiobesity activities. Sprouting leads to higher levels of metabolites in sprouts compared to raw seeds, making it a suitable technique for altering the functional properties of edible seeds depending on the desired activity.
Article
Chemistry, Multidisciplinary
Leilei Zhang, Gokhan Zengin, Gabriele Rocchetti, Ismail Senkardes, Jugreet B. Sharmeen, Mohamad Fawzi Mahomoodally, Tapan Behl, Youssef Rouphael, Luigi Lucini
Summary: In this study, extracts from Rhinanthus angustifolius subsp. grandiflorus were obtained using different extraction techniques and solvents, and evaluated for their antioxidant and enzyme-inhibiting properties. Methanol extracts showed the highest phenolic and flavonoid contents and radical-scavenging antioxidant capacity. Water extracts demonstrated the highest metal chelating activity. Additionally, the extracts showed different enzyme inhibition potentials, with water extracts exhibiting weaker inhibition. This suggests that R. angustifolius is a promising source of natural antioxidants and enzyme inhibitors for pharmaceutical purposes.
APPLIED SCIENCES-BASEL
(2021)
Article
Plant Sciences
Peerapong Jeeno, Sumed Yadoung, Pichamon Yana, Surat Hongsibsong
Summary: Traditional plants from northern Thailand were analyzed for their phytochemical composition and bioactivity. The study found that these plants contain natural bioactive compounds with pharmacological activities, particularly Caesalpinia mimosoides which exhibited the highest antioxidant capacity and chemical content. These traditional plants have the potential to be valuable resources in traditional medicine and for the discovery of new products with similar functions.
Article
Food Science & Technology
Yasir Iqbal, Eric N. Ponnampalam, Jeremy J. Cottrell, Hafiz A. R. Suleria, Frank R. Dunshea
Summary: Narrow leaf plantain, white clover, perennial ryegrass, and tall fescue are non-conventional edible plants with high antioxidant capacity and rich in polyphenols. The study found that these plants contain a variety of polyphenolic compounds, which can be used in human foods, nutraceuticals, and functional foods.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Food Science & Technology
Eugenia Mazzara, Arianna Caprodossi, Ahmed M. Mustafa, Filippo Maggi, Giovanni Caprioli
Summary: This study conducted phytochemical characterization of sumac fruits from five Sicilian accessions, and found that the fruits from San Biagio Platani had higher levels of flavonoids and phenolic acids, while the fruits from Giarratana had higher levels of anthocyanins. These findings suggest that these two accessions are the most suitable settings for sumac cultivation and the development of sumac-based products.
Article
Biochemical Research Methods
Na Guo, Yangan Chen, Xiaofang Yang, Han Yan, Bin Fan, Jianye Quan, Mei Wang, Hongjun Yang
Summary: This study used untargeted and targeted metabolomics approaches to explore the significantly different metabolites related to the Qi stagnation with blood stasis or Qi deficiency with blood stasis subtypes of coronary heart disease (CHD) with angina pectoris. The results showed distinct metabolic profiles not only between CHD patients and healthy controls, but also between the two subtypes of CHD. Pathway analysis revealed subtype-related differences in the activity of pathways, demonstrating the potential of urinary metabolomics in providing evidence for personalized treatment of CHD.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Qiqi Zhou, Lu Gao, Yannan Ji, Xiaoding Zhang, Ningning Shi, Jia Liu, Pengbo Tang, Haixia Gao, Changhong Huo
Summary: In this study, a UHPLC-QTOF-MS method aided by rat intestinal microbiota biotransformation was used to characterize 34 metabolites of Parthenolide (PA) for the first time. The organosulfur metabolites PA-S2-PA and PA-S3-PA were found to generate H2S and inhibit colonic cancer cell viability and IL-6 release. These findings provide a deeper understanding of the action mechanism of PA.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Plant Sciences
Ying Yang, Ting Chen, Jiaming Liu, Sixuan Chen, Rongqing Cai, Liqiong Wu, Jiexiong Hu, Qiongying Lin, Xiaoxiao Qi, Zhongqiu Liu, Yuanyuan Cheng
Summary: This study reveals that Xinbao pill (XBW) has therapeutic effects against myocardial ischaemia-reperfusion injury (MI/RI) by attenuating apoptosis, suppressing excessive autophagy and endoplasmic reticulum (ER) stress.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Food Science & Technology
Raquel Torrijos, Laura Righetti, Martina Cirlini, Luca Calani, Jordi Manes, Giuseppe Meca, Chiara Dall'Asta
Summary: The objective of this study was to investigate the phytochemical profile of yellow and oriental mustard flour and bran fractions. The analysis revealed differences in volatile compounds and bioactive compounds between the two mustard species, with yellow mustard being richer in certain phenolic acids. Additionally, the volatile profile of yellow mustard seeds was described for the first time in this study. The findings suggest that the bran fraction, as a by-product of seed processing, is a valuable source of bioactive compounds for various applications.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Raquel Torrijos, Laura Righetti, Martina Cirlini, Luca Calani, Jordi Manes, Giuseppe Meca, Chiara Dall Asta
Summary: The phytochemical profile and bioactive fraction of yellow mustard and oriental mustard were studied. Various volatile compounds and phenolic compounds were identified, distinguishing the two mustard species. The bran fraction was found to be rich in bioactive compounds and could be used for the recovery of polyphenols.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemical Research Methods
Bowen Huang, Adabelle Ong, Wenli Wang, Yu He, Yongjun Xiao
Summary: The detection and understanding of emerging contaminants (ECs) pose new challenges to water pollution control. Triclosan (TCS), an emerging contaminant widely found in the environment, is a commonly used antibacterial agent. Microdialysis (MD), a sampling technique, combined with UHPLC-QTOF/MS analysis, was used to identify endogenous metabolites as biomarkers of TCS exposure in living crucian carp. The quantification of these biomarkers using UHPLC-MS/MS provided continuous monitoring of the effect of TCS on endogenous metabolites, contributing to a better understanding of its toxicological effect.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Mostafa M. Hegazy, Wael M. Afifi, Ahmed M. Metwaly, Mohamed M. Radwan, Muhamad Abd-Elraouf, Ahmed B. M. Mehany, Eman Ahmed, Shymaa Enany, Shahd Ezzeldin, Adel E. Ibrahim, Sami El Deeb, Ahmad E. Mostafa
Summary: In this study, nine different plants belonging to the Crassulaceae family were selected for investigation. It was found that the extract from Sedum sieboldii leaves exhibited antitrypanosomal activity against Trypanosoma brucei and cytotoxic activities against human cancer cell lines. Additionally, the extract demonstrated inhibition against Topoisomerase-1 and contained a high content of phenolic and flavonoid compounds.
Article
Microbiology
Haiying Ma, Yujuan Niu
Summary: A study found that highly pathogenic fowl adenovirus serotype 4 (FAdV-4) infection can restore the metabolic networks in host cells, and host cell metabolism plays an important role in virus replication. Furthermore, the production of the virus was significantly reduced when the host cells were cultured in glucose or glutamine-deficient conditions.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Garland Kgosi More, Stephen Meddows-Taylor, Gerhard Prinsloo
Summary: This study aimed to determine biochemical variations in five Vachellia species and correlate their metabolite profiles to antioxidant activity. V. karroo, V. kosiensis, and V. xanthophloea demonstrated the highest radical scavenging activity among the tested species. Through advanced analytical techniques, various metabolites responsible for the observed antioxidant activity were identified, providing insights into the potential free radical scavenging activities of Vachellia species.
Article
Agriculture, Multidisciplinary
Yiming Zhang, Lanlan Zhan, Quan Wen, Yulin Feng, Yun Luo, Ting Tan
Summary: This study discovered that taxifolin is able to effectively trap methylglyoxal (MGO), an important precursor of advanced glycation end products (AGEs), by forming MGO adducts in vitro and in vivo. Quantification studies showed that taxifolin and its metabolites can dose-dependently trap MGO. Similar results were observed in diabetic mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Food Science & Technology
Mohamad Fawzi Mahomoodally, Dilmar Aniisah Sanaa, Gokhan Zengin, Monica Gallo, Domenico Montesano
Summary: This study systematically reviewed scientific literature from the past 10 years and highlighted the therapeutic uses of marine animals and animal products globally. It was found that a single aquatic animal could be used for treating multiple ailments, while an ailment could be addressed by several marine animals and animal-derived products. However, there is a lack of validated pharmacological studies to support these traditional uses.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Food Science & Technology
Naoufal E. L. Hachlafi, Tariq Aanniz, Naoual El Menyiy, Aicha El Baaboua, Nasreddine El Omari, Abdelaali Balahbib, Mohammad Ali Shariati, Gokhan Zengin, Kawtar Fikri-Benbrahim, Abdelhakim Bouyahya
Summary: Camphene, a volatile compound found in various aromatic and medicinal plants, has shown multiple biological activities. This review summarizes its biological properties, mechanisms of action, and potential applications as a drug. Further research is needed to validate its use in the pharmaceutical field.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Chemistry, Applied
Gabriele Rocchetti, Annalisa Rebecchi, Constanza Maria Lopez, Michele Dallolio, Giuliano Dallolio, Marco Trevisan, Luigi Lucini
Summary: This study evaluated the impact of glucose and mixed starter cultures on the quality of Italian salami. The addition of glucose had a significant effect on the metabolites and sensory profiles of the salami.
Article
Food Science & Technology
Giulia Sesini, Greta Castellini, Paola Iannello, Linda Lombi, Edoardo Lozza, Luigi Lucini, Guendalina Graffigna
Summary: The demand for organic food has increased in recent years, as well as the requests for food authentication and safety. Omics technologies can effectively respond to these needs, enhance the transmission of food safety information, and differentiate between organic and conventional products. However, there is limited knowledge about consumers' perception of this novel certification approach.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Simon Vlad Luca, Gokhan Zengin, Kouadio Ibrahime Sinan, Krystyna Skalicka-Wozniak, Adriana Trifan
Summary: This study characterized and assessed the phytochemicals and biological activities of the essential oils and extracts of three Lamiaceae species. The results showed that they are rich in bioactive metabolites with antioxidant and enzyme inhibitory properties.
Article
Biochemistry & Molecular Biology
Gokhan Zengin, Alvaro Fernandez-Ochoa, Maria de la Luz Cadiz-Gurrea, Francisco Javier Leyva-Jimenez, Antonio Segura-Carretero, Fevzi Elbasan, Evren Yildiztugay, Sumira Malik, Asaad Khalid, Ashraf N. Abdalla, Mohamad Fawzi Mahomoodally
Summary: This study investigated the phytochemical profile and biological properties of Paliurus spina-christi Mill., a medicinal plant traditionally used for various human ailments. The methanol extract exhibited the strongest antioxidant and anti-tyrosinase activities. These findings contribute to the understanding of P. spina-christi as a potential source of naturally occurring bioactive compounds with biomedical applications.
Article
Biochemistry & Molecular Biology
Leilei Zhang, Gabriele Rocchetti, Gokhan Zengin, Daniele Del Buono, Marco Trevisan, Luigi Lucini
Summary: The present study evaluated the potential of common duckweed as a source of bioactive compounds. Untargeted profiling of the bioactive components was done using UHPLC-HRMS, and in vitro antioxidant and enzymatic inhibition properties were assessed. The results showed that common duckweed is rich in carotenoids and flavonoids, with the highest correlation values to the bioactive properties. The optimized extraction parameters revealed that ethanol percentage has a pivotal impact on the recovery of bioactive compounds.
Article
Biochemistry & Molecular Biology
Francesco Cristofano, Christophe El-Nakhel, Giuseppe Colla, Mariateresa Cardarelli, Youry Pii, Luigi Lucini, Youssef Rouphael
Summary: Protein hydrolysate biostimulants are environmentally friendly options for reducing nitrogen input, but their plant growth-promoting mechanisms are still not fully understood.
Article
Food Science & Technology
Gabriele Rocchetti, Pier Paolo Becchi, Lorenzo Salis, Luigi Lucini, Andrea Cabiddu
Summary: Untargeted metabolomics was used to investigate the effect of different pasture-based diets on the chemical composition of Sarda sheep milk. A total of 11 dairy sheep farms located in Sardinia were included in the study, and milk samples were collected in four different periods. The analysis identified 406 metabolites, including amino acids, monosaccharides, fatty acids, phenolic acids, and flavonoids. The results showed that the composition of sheep milk varied based on the intake of fresh herbage, while the intake of hay and concentrate did not significantly affect the milk composition. Discriminant markers of herbage intake included phenolic metabolites, carotenoids, and their metabolites, as well as lipid derivatives, sugars, amino acids, and peptides. Pathway analysis revealed the impact of herbage intake on several biochemical pathways related to metabolism and protein synthesis.
Article
Chemistry, Analytical
Gokhan Zengin, Adriano Mollica, Jelena Arsenijevic, Branimir Pavlic, Zoran Zekovic, Kouadio Ibrahime Sinan, Linlin Yan, Aleksandra Cvetanovic Kljakic, Slavica Razic
Summary: In this study, traditional and modern separation techniques such as hydrodistillation and supercritical fluid extraction were utilized to efficiently extract high-value compounds from chamomile. GC analysis revealed that oxygenated sesquiterpenes and non-terpene compounds were the dominant components, with alpha-bisabolol oxide A and alpha-bisabolol oxide B being the most abundant individual compounds. The biological potential of the essential oils and extracts showed that the essential oils had better antioxidant activity, while the extracts exhibited better inhibition of the tested enzymes. Molecular docking experiments identified alpha-bisabolol oxide B as having higher affinity for tyrosinase.
Article
Biochemistry & Molecular Biology
Martina Cirlini, Laura Righetti, Lorenzo Del Vecchio, Elena Tonni, Luigi Lucini, Chiara Dall'Asta, Gianni Galaverna
Summary: Meat quality is influenced by animal feeding and various studies have shown that incorporating antioxidant components in animal feed can improve meat quality. In this study, an in vitro digestion protocol was applied to pork muscles obtained from pigs fed different diets. The results showed that the addition of linseeds and polyphenols in the animal diet reduced the metabolites generated from oxidative degradation reactions and improved meat quality.
Review
Microbiology
Yusufjon Gafforov, Milena Raseta, Sylvie Rapior, Manzura Yarasheva, Xuewei Wang, Liwei Zhou, Wan Abd Al Qadr Imad Wan-Mohtar, Muhammad Zafar, Young Woon Lim, Mengcen Wang, Bekhzod Abdullaev, Rainer W. Bussmann, Gokhan Zengin, Jiajia Chen
Summary: Interest in edible and medicinal macrofungi has a long history in Central Asia, while interest in inedible and medicinal macrofungi has recently increased. A study conducted in Uzbekistan collected various species of edible and inedible medicinal basidiomycetes. The research focused on measuring diversity and habitat associations using morphological characters and rDNA-Internal Transcribed Spacer sequence data. The study identified 17 species of medicinal macrofungi associated with 23 species of trees and shrubs. The findings provide valuable information on the traditional and modern uses of these mushrooms, including their potential application as medicines, food, and cosmetic ingredients.
Article
Agriculture, Multidisciplinary
Hajar Salehi, Leilei Zhang, Fatma Nur Alp-Turgut, Busra Arikan, Fevzi Elbasan, Ceyda Ozfidan-Konakci, Melike Balci, Gokhan Zengin, Evren Yildiztugay, Luigi Lucini
Summary: This study investigated the impact of naringenin and rosmarinic acid on the functional properties of Lepidium sativum leaves and roots. The results showed that there was a tissue-specific modulation of bioactive compounds, and the application of rosmarinic acid had positive effects on antioxidant and enzyme inhibitory activities. This has important implications for shaping the health-promoting properties of L. sativum.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Food Science & Technology
Sofia Galimberti, Gabriele Rocchetti, Francesca Di Rico, Chiara Rossetti, Alessandra Fontana, Luigi Lucini, Maria Luisa Callegari
Summary: This study developed a novel approach to investigate the role of natural starters in browning of hard cheeses. By measuring growth, color changes, methylglyoxal production, and metabolomics, differences in browning among strains were detected, indicating the involvement of amino acids and proteolysis in the process.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Yonghong Ye, Songyan Zheng, Yuanxing Wang
Summary: In this study, the changes of aroma components in Gannan navel orange during growth were systematically studied using HS-SPME-GC-MS. Key aroma components and markers were identified. These findings contribute to a better understanding of the dynamic variation of aroma compounds during navel orange growth and have potential for industrial applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Jia Xu, Yayuan Zhang, Mengke Zhang, Xinlin Wei, Yiming Zhou
Summary: This study evaluated the effects of glucosamine selenium on summer-autumn tea, showing that it can enhance nutritional quality, improve sensory characteristics, and increase plant adaptation to environmental changes and abiotic stresses.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yuanming Chu, Zhaoyang Ding, Jing Xie
Summary: This study investigated the use of ice glazing containing D-sodium erythorbate (DSE) and vacuum packaging to maintain the quality of large yellow croaker during frozen storage. The results showed that vacuum packaging effectively inhibited ice crystal growth and minimized water loss, while the combination of vacuum packaging and 0.3% DSE-infused ice glazing maintained freshness indicators at low levels throughout the 300-day storage period. This combination was considered the most effective in preserving the quality of the fish.
FOOD RESEARCH INTERNATIONAL
(2024)
Review
Food Science & Technology
Md. Ashikur Rahman, Shirin Akter, Md. Ashrafudoulla, Md. Anamul Hasan Chowdhury, A. G. M. Sofi Uddin Mahamud, Si Hong Park, Sang-Do Ha
Summary: This comprehensive review aims to provide insights into the mechanisms and key factors influencing biofilm formation by A. hydrophila in the food industry. It explores the molecular processes involved in various stages of biofilm formation and investigates the impact of intrinsic factors and environmental conditions on biofilm architecture and resilience. The article also highlights the potential of bibliometric analysis in conceptualizing the research landscape and identifying knowledge gaps in A. hydrophila biofilm research.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Chujing Wang, Wenni Tian, Zengliu Song, Qun Wang, Yong Cao, Jie Xiao
Summary: Solid lipid ratio in emulsions has significant effects on colloidal stability, mucus permeability, and bioavailability in vivo. Higher solid lipid ratio improves intestinal stability but reduces mucus permeability.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Dacai Zhong, Liping Kang, Juan Liu, Xiang Li, Li Zhou, Luqi Huang, Zidong Qiu
Summary: In this study, a novel online extraction electrospray ionization mass spectrometry method was developed to comprehensively characterize complex foods. Meanwhile, a characteristic marker screening method and chemometrics modeling were used for the accurate authentication of highly-similar foods. This research has significant implications for ensuring food quality and safety.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Qiannan Zhao, Jinyi Yang, Jiahui Li, Lei Zhang, Xiaohai Yan, Tianli Yue, Yahong Yuan
Summary: This study investigated the transport and hypoglycemic effects of phenolics in mulberry leaves using an in vitro digestion model. The results showed that digested phenolics had higher absorbability and could inhibit glucose digestion and absorption. Phenolics also regulated glucose metabolism. Luteoforol and p-coumaric acid were found to be the primary phenolics strongly correlated with the hypoglycemic ability of mulberry leaves.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yanyun Cao, Qingling Wang, Jinou Lin, Yin-Yi Ding, Jianzhong Han
Summary: This study investigated the effects of gallic acid (GA) and epigallocatechin gallate (EGCG) at different ratios on the gel properties of calcium induced-whey protein emulsion gel. It was found that GA and EGCG could promote gel formation, increase gel strength, and delay the release of emulsified oil droplets.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Monique Martins Strieder, Vitor Lacerda Sanches, Mauricio Ariel Rostagno
Summary: This study proposed an integrated and automated procedure for extracting, separating, and quantifying bioactive compounds from coffee co-products. By optimizing the extraction, separation, and analysis method, real-time analysis was achieved. The results suggest that coupling different techniques can efficiently extract, separate, and analyze phenolic compounds, providing an integrated method to produce high-added value ingredients for various applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Kyu Sang Sim, Hyoyoung Kim, Suel Hye Hur, Tae Woong Na, Ji Hye Lee, Ho Jin Kim
Summary: Geographical origin plays a crucial role in determining the quality and safety of agricultural products. In this study, ICP analysis was used to determine the inorganic elemental content of onions and identify their geographical origin. Chemometric methods were applied to analyze the ICP results, and the accuracy of distinguishing between Korean and Chinese onions was found to be excellent. The findings suggest that this method can be beneficial for identifying agricultural products.
FOOD RESEARCH INTERNATIONAL
(2024)