Journal
EXPERT REVIEW OF MEDICAL DEVICES
Volume 18, Issue 5, Pages 429-437Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/17434440.2021.1921572
Keywords
Essential tremor; Magnetic Resonance guided Focused Ultrasound; Magnetic Resonance; Ultrasound; Tremor; Movement Disorders; Thalamotomy
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MRgFUS is an emerging technique that uses high-energy low-frequency ultrasound beams for thermal ablation, with the ExAblate Neuro 4000 system being a leading brain system for MRgFUS applications. The precision targeting of this technology offers new possibilities for treating neurological diseases, but challenges remain to be overcome for its safety and efficacy in clinical settings.
Introduction: Magnetic Resonance guided Focused UltraSound (MRgFUS) is an emerging technique that utilizes multiple high-energy low-frequency ultrasound beams generated from a multi-element transducer focused onto a single site to cause thermal ablation of the target tissue. The ExAblate Neuro 4000 system is the leading MRgFUS brain system, performing targeted thermal ablation on specific nuclei in the brain. Its precision targeting opens up new and exciting possibilities for future treatments of a wide range of neurological diseases. Areas covered: This article aims to introduce the non-expert reader (clinician and non-clinicians) to the role of the ExAblate Neuro 4000 System in brain MRgFUS. The current clinical uses of the ExAblate system in the brain are explored with a particular focus on Essential Tremor, where internationally there is most experience, this includes reference to current literature. The safety and efficacy of MRgFUS treatments are explored and the challenges the ExAblate system must overcome to balance these juxtaposed outcomes.Expert opinion: We describe the hopes for future clinical uses of the ExAblate Neuro 4000 system to treat neurological disease and consider further advancements in MRgFUS transducer technology that may open up new exciting frontiers within the brain.
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