Article
Medicine, Research & Experimental
Yueheng Tang, Hongzhan Wang, Kexin Nie, Yang Gao, Hao Su, Zhi Wang, Fuer Lu, Wenya Huang, Hui Dong
Summary: This study found that Jiao-tai-wan (JTW) has antidepressant activity, possibly through inhibiting NLRP3 inflammasome activation and improving inflammatory state. The results of this study are of great significance for exploring the antidepressant mechanisms of JTW.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Yimeng Chen, Lijuan Zhu, Wenxin Hu, Yuping Wang, Xiaodong Wen, Jie Yang
Summary: Simiao Wan exerts beneficial effects on insulin resistance and hepatic lipid accumulation by regulating profiles of gut microbiota and bile acids.
Article
Biochemistry & Molecular Biology
Yuting Zhang, Huimin Chen, Wei Cong, Ke Zhang, Yimin Jia, Lei Wu
Summary: Heat stress can hinder the growth performance of broilers, leading to economic losses. The study found that chronic heat stress resulted in a decrease in total bile acids and an increase in cholic acid, chenodeoxycholic acid, and taurolithocholic acid in broilers. The expression of CYP8B1 and BSEP increased in the liver, while the expression of FGF19 decreased in the ileum of heat-stressed broilers. Significant changes in gut microbial composition were also observed, with the enrichment of Peptoniphilus being positively correlated with the increased serum level of taurolithocholic acid.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Guiqin Bai, Yiqi Qiao, Po-Chieh Lo, Lei Song, Yuna Yang, Lining Duan, Sufen Wei, Min Li, Shuiqing Huang, Beiping Zhang, Qi Wang, Cong Yang
Summary: The study showed that Jiao-Tai-Wan may ameliorate neuronal damage in depression mice by inhibiting CSF1R-mediated microglia activation and pro-inflammatory response.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Yanbo Kou, Xingping Zheng, Liyuan Meng, Mengnan Liu, Shihong Xu, Qiyue Jing, Shenghan Zhang, Hanying Wang, Jinzhi Han, Zhuanzhuan Liu, Yanxia Wei, Yugang Wang
Summary: HVEM and BTLA deficiencies exacerbate liver injury and impair liver repair, potentially due to impaired neutrophil accumulation after injury. HVEM and BTLA deficiencies affect hepatic neutrophil accumulation and may restrain liver injury by regulating gut microbiota.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xin Liu, Xingsi Qi, Rongshuang Han, Tao Mao, Zibin Tian
Summary: This study investigated the causal relationship between gut microbiota and cholelithiasis. The researchers hypothesized that gut microbiota influences the development of cholelithiasis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mingrui Zhang, Ruixia Mo, Haotian Wang, Tianyi Liu, Gang Zhang, Yi Wu
Summary: This study evaluated the effect of grape seed proanthocyanidin (GSP) on Labrador Retrievers with mild inflammatory bowel disease (IBD) and found that GSP can alleviate intestinal inflammation by altering gut microbial composition and improving bile acid metabolism.
Article
Biochemistry & Molecular Biology
Suzhen Lei, Lu Liu, Linyu Ding, Yi Zhang, Hongliang Zeng
Summary: The study found that lotus seed resistant starch can affect the conversion of sodium taurocholate by regulating intestinal flora, particularly promoting the proliferation of Bifidobacterium and Escherichia Shigella, which accelerates specific substance hydrolysis and influences bile salt content and conversion process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Analytical
Wenbo Wang, Shuangquan Zhu, Hao Chen, Ning Wu, Han Chen, Dongsheng Wang
Summary: A rapid, accurate, and sensitive method using ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry was developed for the simultaneous determination of 10 main components in Ge-Gen-Jiao-Tai-Wan. The method showed excellent linear regressions, low precision, repeatability, and stability, and high extraction recovery.
JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY
(2022)
Article
Integrative & Complementary Medicine
Juan Liu, Yuzhu Tan, Hui Ao, Wuwen Feng, Cheng Peng
Summary: The study demonstrates that Aconite aqueous extracts enhance thermogenesis in rats by modulating gut microbiota composition and bile acids metabolism, leading to increased body temperature, browning of white adipose tissue, and enhanced thermogenesis in brown adipose tissue.
Article
Engineering, Environmental
Zhiyuan Meng, Sen Yan, Wei Sun, Jin Yan, Miaomiao Teng, Ming Jia, Sinuo Tian, Zhiqiang Zhou, Wentao Zhu
Summary: This study found that chlorothalonil (CHI), the most commonly used organochlorine pesticide nowadays, can induce obesity in mice based on ADI level, and also causes an imbalance in the gut microbiota of the mice. Furthermore, the study discovered that CHI disturbs the bile acids metabolism in mice, causing glycolipid metabolism disorders and obesity through the FXR signaling pathway. This study provides evidence linking gut microbiota and pesticide exposure with the progression of obesity, highlighting the importance of gut microbiota in the toxic effects of pesticides.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Immunology
Hao Cheng, Dandan Zhang, Jing Wu, Juan Liu, Yuzhu Tan, Wuwen Feng, Cheng Peng
Summary: This study found that Atractylodes macrocephala Koidz. volatile oil (AVO) has a beneficial effect on acute ulcerative colitis by modulating the composition and metabolism of gut microbiota. AVO can alleviate diarrhea, colon damage, and inflammation caused by colitis, while decreasing potentially harmful bacteria and increasing potentially beneficial bacteria. These effects may be attributed to the regulation of gut microbiota metabolism by AVO.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wei-Hsiang Hsu, Li-Jen Lin, Chung-Kuang Lu, Shung-Te Kao, Yun-Lian Lin
Summary: The study found that asthma induced by dust mites can cause significant changes in metabolite levels, and You-Gui-Wan can affect branched-chain amino acid metabolism, alleviating asthma by improving gut microbiota composition.
Article
Fisheries
Yanpeng Zhang, Xu-Fang Liang, Shan He, Hexiong Feng, Ling Li
Summary: The study identified Bacillus subtilis BS1 and Lactobacillus plantarum LP1 as potential probiotics for aquaculture, showing that probiotics can affect growth performance and gut health by regulating gut microbiota.
Article
Fisheries
Yanpeng Zhang, Hexiong Feng, Xu-Fang Liang, Shan He, Jie Lan, Ling Li
Summary: The study investigates the effects of dietary bile acids supplementation on lipid metabolism and gut health of Chinese perch. The results show that dietary BAs supplementation can reduce liver lipid deposition and improve gut health by regulating gut microbiota.
FISH & SHELLFISH IMMUNOLOGY
(2022)