Article
Virology
Francisco Noe Fonseca, Vanessa Haach, Franciana Volpato Bellaver, Gabrielly Bombassaro, Danielle Gava, Luciano Paulino da Silva, Lana Flavia Baron, Mayara Simonelly, Wanessa Araujo Carvalho, Rejane Schaefer, Ana Paula Bastos
Summary: A polyvalent virosome influenza vaccine containing hemagglutinin and neuraminidase proteins derived from swine influenza A viruses (swIAVs) was developed and shown to induce efficient immune response and provide long-lasting immunity in mice.
Article
Microbiology
Weigang Ren, Shuli Pei, Wenming Jiang, Meixia Zhao, Le Jiang, Honggang Liu, Yongxiang Yi, Mizhou Hui, Junwei Li
Summary: A replication-deficient recombinant influenza virus was developed in this study, which stimulated robust immune response and conferred complete protection against H5N1 or H9N2 influenza virus infections in mice.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Yonghong Liu, Shirin Strohmeier, Irene Gonzalez-Dominguez, Jessica Tan, Viviana Simon, Florian Krammer, Adolfo Garcia-Sastre, Peter Palese, Weina Sun
Summary: By generating and sequentially vaccinating mice with inactivated influenza B viruses displaying mosaic HAs, researchers have successfully induced long-lasting and cross-protective antibody responses. These findings represent a significant step towards the development of a universal influenza B virus vaccine.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marina Repkova, Asya Levina, Zinfer Ismagilov, Natalia Mazurkova, Oleg Mazurkov, Valentina Zarytova
Summary: The study found that using TiO2-based nanocomposites similar to ODNs for ODN delivery can effectively inhibit A/H7N9 virus in vitro and in vivo. Targeting ODN to the conserved terminal 3'-noncoding region of viral RNA can provide efficient, sequence-specific, and dose-dependent protection, significantly reducing the virus titer in infected mice.
NUCLEIC ACID THERAPEUTICS
(2021)
Article
Virology
Hae-Ji Kang, Ki-Back Chu, Keon-Woong Yoon, Gi-Deok Eom, Jie Mao, Min-Ju Kim, Su-Hwa Lee, Eun-Kyung Moon, Fu-Shi Quan
Summary: Research suggests that avian influenza VLP vaccines expressing multiple neuraminidases can provide both homologous and heterosubtypic protection against different subtypes, offering a promising approach for developing a universal influenza A vaccine against avian and human influenza virus infections.
Article
Immunology
Jerald R. Chavez, Wangyuan Yao, Harrison Dulin, Jasmine Castellanos, Duo Xu, Rong Hai
Summary: Due to the lack of pandemic potential, research on the pathology and immunological responses of IBV lags behind that of IAV. The impact of lifestyle and environmental factors, such as cigarette smoking, on IBV infections is still unclear. By pre-treating mice with cigarette smoke extract for two weeks, infecting them with IBV, and monitoring the effects, we developed an animal model system. The results showed that cigarette smoke extract treatment decreased IBV specific IgG levels but did not change viral replication and weight recovery post infection in the upper airway/lung. However, higher concentrations of cigarette smoke extract did lead to higher mortality post infection, suggesting that inflammation induced by smoking coupled with IBV infection resulted in exacerbated disease outcome.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Wenwei Lu, Zhifeng Fang, Xinyang Liu, Lingzhi Li, Pinghu Zhang, Jianxin Zhao, Hao Zhang, Wei Chen
Summary: This study found that probiotics can play a protective role in influenza virus infection, promoting immune function recovery and reducing viral load. By regulating gut microbiota composition and SCFA metabolism, probiotics can enhance resistance to influenza virus.
Article
Immunology
Paul W. Rothlauf, Zeyang Li, Novalia Pishesha, Yushu Joy Xie, Andrew W. Woodham, Djenet Bousbaine, Stephen C. Kolifrath, Vincent L. Verschoor, Hidde L. Ploegh
Summary: Immuno-positron emission tomography (immuno-PET) is a noninvasive imaging method that allows for tracking immune cells in living animals. In a study using mouse models, CD8(+) T cells labeled with a Zr-89 nanobody showed specific migration patterns during an influenza A virus infection, suggesting a potential role in immune response modulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Kimberly Braz Gomes, Sucheta D'Sa, Grace Lovia Allotey-Babington, Sang-Moo Kang, Martin J. D'Souza
Summary: The study utilized the highly conserved M2e VLP as a potential vaccine candidate against influenza, showing promising immunogenic potential and protective effects when administered transdermally in a pre-clinical mouse model.
Article
Virology
Xingui Tian, Shelby Landreth, Yao Lu, Kannupriya Pandey, Yan Zhou
Summary: The engineering of the H5 or H7 HA gene in segment 6 affects the immunogenicity of the virus, and PR8-H5-H7(NA) has strong potential to serve as a vaccine candidate against both H5 and H7 subtypes of avian influenza viruses.
JOURNAL OF VIROLOGY
(2021)
Article
Chemistry, Multidisciplinary
Qian Niu, Ling Ma, Shaobin Zhu, Lan Li, Qisheng Zheng, Jibo Hou, Hong Lian, Lina Wu, Xiaomei Yan
Summary: The development of a high-throughput single-particle method for quantifying intact viral particles is crucial for both basic research on viral diseases and clinical application. By using nucleic acid dye and a laboratory-built nano-flow cytometer, different types of viral particles can be effectively discriminated.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Immunology
Santosh Dhakal, Sharvari Deshpande, Meagan McMahon, Shirin Strohmeier, Florian Krammer, Sabra L. Klein
Summary: This study compares the effects of sex and age on universal influenza vaccine-induced immunity. The results show that adult mice develop more and higher quality antibodies compared to aged mice, providing better protection. Male mice experience less decline in immunity and protection compared to females. Transferring serum from young mice to aged mice cannot reverse this decline in immunity. Therefore, the sex-specific effects of aging on immunity are significant and should be considered in the development of universal vaccines.
Article
Immunology
Xingtian Kong, Lizheng Guan, Jianzhong Shi, Huihui Kong, Yaping Zhang, Xianying Zeng, Guobin Tian, Liling Liu, Chengjun Li, Yoshihiro Kawaoka, Guohua Deng, Hualan Chen
Summary: This study characterized two H5N6 avian influenza viruses with different lethality in mice, attributing the difference in virulence to a mutation in the HA gene. The mutation G225W in the HA protein decreased the stability and increased the activation pH of the virus, providing a potential target for the development of vaccines and drugs against H5 influenza viruses.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Microbiology
Kin Kui Lai, James B. B. Munro, Guoli Shi, Saliha Majdoul, Alex A. A. Compton, Alan Rein
Summary: Serine incorporator 5 (Ser5) is a host antiviral factor against HIV-1, gammaretroviruses, and Influenza A virus (IAV). It inhibits virus-cell fusion by interacting with HA proteins and destabilizing the pre-fusion conformation of IAV HA. This study provides insights into the antiviral mechanism of Ser5.
Article
Virology
Pinar Yazici ozkaya, Ese Eda Turanli, Hamdi Metin, Ayca Aydin Uysal, Candan cicek, Bulent Karapinar
Summary: This study aimed to identify the clinical features and mortality associated with severe influenza A and B virus infections in children admitted to the pediatric intensive care unit (PICU) between 2012 and 2019. The study found that although the proportion of influenza A cases admitted to the PICU was higher, the percentage of cases requiring PICU admission was nearly two times higher in influenza B cases. Additionally, there was no statistically significant difference in disease severity and complications in patients with influenza A and influenza B.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Chemistry, Physical
Lyudmila B. Okhlopkova, Mikhail A. Kerzhentsev, Zinfer R. Ismagilov
Summary: A series of mixed oxides TixZn1-xO1+x were synthesized and used as a matrix for PdZn catalytic coating in selective hydrogenation. The PdZn catalytic coating based on Zn-doped titania showed high selectivity and maintained it for a long time in continuous reaction.
REACTION KINETICS MECHANISMS AND CATALYSIS
(2022)
Article
Thermodynamics
B. P. Aduev, Y. Kraft, D. R. Nurmukhametov, Z. R. Ismagilov
Summary: This study investigated the ignition characteristics of coal particles with different metamorphic grades under microsecond laser pulses and revealed three stages with distinct ignition thresholds and combustion durations. The energy fraction absorbed by flame and thermal decomposition products of coal particles was determined, and the reflection and absorption coefficients of coal particles were measured at each ignition stage.
COMBUSTION SCIENCE AND TECHNOLOGY
(2022)
Article
Physics, Atomic, Molecular & Chemical
B. P. Aduev, D. R. Nurmukhametov, Ya Kraft, Z. R. Ismagilov
Summary: The study found that the emission spectra and chemical reactions of coal particles under laser pulse irradiation are related to the metamorphism rank of coal, with changes in energy density significantly affecting the chemical reaction rates and combustion processes in coal particles.
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Medicine, Research & Experimental
Maxim S. Kupryushkin, Anton Filatov, Nadezhda L. Mironova, Olga A. Patutina, Ivan Chernikov, Elena L. Chernolovskaya, Marina A. Zenkova, Dmitrii Pyshnyi, Dmitry A. Stetsenko, Sidney Altman, Valentin V. Vlassov
Summary: Antisense gapmer oligonucleotides containing phosphoryl guanidine (PG) groups were successfully synthesized and shown to have increased nuclease resistance in serum-containing medium. Replacing two internucleotidic phosphates with PG groups did not decrease cellular uptake, and increasing the number of PG groups affected cellular uptake.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Pharmacology & Pharmacy
Asya Levina, Marina Repkova, Maxim Kupryushkin, Alisa Seryapina, Oleg Shevelev, Dmitrii Pyshnyi, Valentina Zarytova, Arcady Markel
Summary: The study found that Si-ODN can decrease blood pressure in ISIAH rats, while scrambled oligonucleotides were ineffective. The nanocomposite delivery system is suitable for both natural and modified oligonucleotides. Additionally, the Si-ODN nanocomposites demonstrated no toxicity under the studied conditions.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Energy & Fuels
Vyacheslav G. Smirnov, Andrey Y. Manakov, Zinfer R. Ismagilov
Summary: A new equation describing the equilibrium conditions for gas hydrate in thin pores of mesoporous materials is proposed in this study. The equation takes into account the size of hydrate particles together with the chemical potential of pore water in equilibrium with the hydrate. The modeling results are in reasonable qualitative agreement with the experimental data.
Article
Biochemistry & Molecular Biology
Timofey D. Zharkov, Ekaterina M. Mironova, Oleg V. Markov, Sergey A. Zhukov, Svetlana N. Khodyreva, Maxim S. Kupryushkin
Summary: In this study, various chemical approaches were used to successfully synthesize lipophilic oligonucleotides with different structures, and their impact on cell penetration was evaluated. The results indicate that the developed chemical methods not only allow for the synthesis of complex oligonucleotide structures, but also enable fine-tuning of their properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
S. A. Sozinov, A. N. Popova, S. Yu. Lyrshchikov, Z. R. Ismagilov
Summary: Scanning electron microscopy, NMR spectroscopy, XRD, thermal analysis and gas chromatography-mass spectrometry were used to study the composition, structure and morphology of alpha 2-fraction powders isolated from medium-temperature coal-tar pitch. The study revealed that the alpha 2-fraction is primarily composed of condensed aromatic compounds containing N, O and S heteroatoms, with sulfur mainly in the form of heat-resistant thiophene compounds. The thermolysis of the alpha 2-fraction resulted in the formation of denser coke particles with a carbon content ranging from 90% to 93% at temperatures between 300 and 600 degrees C. Further heating up to 1200 degrees C increased the carbon content to 97% and led to the formation of coke particles with a layered structure resembling premium class needle cokes.
CHEMISTRY FOR SUSTAINABLE DEVELOPMENT
(2022)
Article
Chemistry, Multidisciplinary
S. A. Sozinov, A. N. Popova, N. I. Fedorova, Z. R. Ismagilov
Summary: The vitrinite concentrates of coal at different stages of metamorphism were studied using scanning electron microscopy and X-ray diffraction analysis. The results showed that an increase in metamorphism degree led to an increase in electrical conductivity and a decrease in reflectivity of vitrinite particles. X-ray diffraction analysis revealed the formation of a turbostratic carbon structure in the vitrinites, with an increase in metamorphism stage resulting in an increase in the dimensions of structured vitrinite fragments.
CHEMISTRY FOR SUSTAINABLE DEVELOPMENT
(2022)
Article
Chemistry, Multidisciplinary
Ya. V. Kraft, A. B. Aduev, N. V. Nelyubina, V. D. Volkov, Z. R. Ismagilov
Summary: This study investigates the effect of pulsed nanosecond laser radiation on high volatile C bituminous coal in an argon medium. The results show that the volume of combustible gases formed increases with the power density of the laser, but remains almost unchanged at higher power densities. Additionally, the presence of a binding material in the tableted samples also influences the effect of laser radiation.
EURASIAN CHEMICO-TECHNOLOGICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
P. N. Kuznetsov, Z. R. Ismagilov, L. I. Kuznetsova, B. Avid, X. Fan, E. S. Mihkailova
Summary: The dissolution of bituminous coal at mild temperature using low volatile solvents like highly aromatic coal tar and petroleum-derived solvent was studied. The extracts obtained were similar to pitch-like matter and the blended solvents yielded more extracts with molecular indexes average between those obtained with each solvent separately. Additionally, the extracts obtained had significantly lower content of benzo(a) pyrene compared to the solvents used.
EURASIAN CHEMICO-TECHNOLOGICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
S. I. Zherebtsov, K. M. Shpakodraev, K. S. Votolin, N. V. Malyshenko, Z. R. Ismagilov
Summary: This article mainly studies the characteristics of samples of brown coal, bitumen, and humic acids, as well as the presence of biologically active substances in extracted bitumen samples. The results show that O-alkylation of the organic mass of coal can change the structural-group composition of humic acids, increase aromaticity, and enhance biological activity.
EURASIAN CHEMICO-TECHNOLOGICAL JOURNAL
(2022)
Article
Thermodynamics
B. P. Aduev, D. R. Nurmukhametov, Ya Kraft, Z. R. Ismagilov
Summary: This study investigates the ignition of nine coal marks from the Kuznetsk Basin using laser pulses. Different types of ignition processes were identified based on the energy density of the laser pulse, characterized by threshold, temporal, and spectral-kinetic characteristics.
COMBUSTION EXPLOSION AND SHOCK WAVES
(2022)
Article
Engineering, Environmental
Haihong Zhao, Ning Zhao, Ekaterina V. Matus, Zinfer R. Ismagilov, Lei Li, Fukui Xiao
Summary: The novel composite Cu-BTC-(n)Br/MCFs synthesized in this study showed promising CO2 adsorption capacity and effectiveness, as well as good stability in multiple adsorption-desorption cycles. The material has potential applications in practical CO2 capture scenarios.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Engineering, Chemical
V. Yu Malysheva, N. Fedorova, A. P. Nikitin, Z. R. Ismagilov
Summary: The vitrinite components of coal from different metamorphic stages were studied using thermogravimetric analysis and Raman spectroscopy in an oxidative medium. The results showed that as the metamorphic development increased, the oxidative temperatures of vitrinites also rose, and the maximum rate of decomposition shifted to higher temperatures. Linear correlations were found between the ignition temperature of vitrinite components and coal characteristics such as organic carbon content, vitrinite reflection coefficient, and volatile yield. Raman spectroscopy provided structural parameters of the samples, indicating their aromatic content and the characteristics of oxygen-containing and hydroaromatic fragments. Correlations were established between these structural parameters and the temperatures of oxidative transformation.
COKE AND CHEMISTRY
(2022)