An insight on medicinal aspects of novel HIV-1 capsid protein inhibitors

Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities

(2020) Lin Sun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploratory studies on CA-15L, an anti-HIV active HIV-1 capsid fragment

(2020) Kohei Tsuji et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Medicinal chemistry strategies of targeting HIV-1 capsid protein for antiviral treatment

(2020) Shujing Xu et al.   Future Medicinal Chemistry

Clinical targeting of HIV capsid protein with a long-acting small molecule

(2020) John O. Link et al.   NATURE

Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro

(2020) Devin E. Christensen et al.   SCIENCE

Potent leads based on CA-19L, an anti-HIV active HIV-1 capsid fragment

(2020) Kohei Tsuji et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Long-acting drugs and formulations for the treatment and prevention of HIV infection

(2020) Charles Flexner et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle

(2019) Mariia Novikova et al.   VIROLOGICA SINICA

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

(2019) Stephen R. Yant et al.   NATURE MEDICINE

Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library

(2018) Gaochan Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication

(2016) Suzie Thenin-Houssier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly

(2016) Milan Kožíšek et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

HIV-1 Capsid Inhibitors as Antiretroviral Agents

(2016) Suzie Thenin-Houssier et al.   CURRENT HIV RESEARCH

Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74

(2016) Akatsuki Saito et al.   JOURNAL OF VIROLOGY

HIV-1 capsid is involved in post-nuclear entry steps

(2016) Nan-Yu Chen et al.   Retrovirology

Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends

(2015) Peng Zhan et al.   JOURNAL OF MEDICINAL CHEMISTRY

HIV-1 assembly, release and maturation

(2015) Eric O. Freed   NATURE REVIEWS MICROBIOLOGY

Structural basis of HIV-1 capsid recognition by PF74 and CPSF6

(2014) Akash Bhattacharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of HIV-1 capsid in viral replication and immune evasion

(2014) Valerie Le Sage et al.   VIRUS RESEARCH

Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly

(2014) Amanda J. Price et al.   PLoS Pathogens

A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallizationviacompound-mediated dimerization

(2013) Christopher T. Lemke et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes

(2013) Louie Lamorte et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular basis of human immunodeficiency virus type 1 drug resistance: Overview and recent developments

(2013) Luis Menéndez-Arias   ANTIVIRAL RESEARCH

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: Structure–activity relationships (SAR) of the C3-phenyl moiety

(2013) Lee D. Fader et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: Addressing configurational instability through scaffold modification

(2013) Lee D. Fader et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

HIV-1 entry inhibitors: recent development and clinical use

(2013) Timothy J Henrich et al.   Current Opinion in Virology

Antiviral Drug Resistance and the Need for Development of New HIV-1 Reverse Transcriptase Inhibitors

(2012) Eugene L. Asahchop et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold

(2012) Martin Tremblay et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibiting Early-Stage Events in HIV-1 Replication by Small-Molecule Targeting of the HIV-1 Capsid

(2012) Sandhya Kortagere et al.   JOURNAL OF VIROLOGY

Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein

(2012) C. T. Lemke et al.   JOURNAL OF VIROLOGY

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

(2010) Lee D. Fader et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure of the HIV-1 Full-Length Capsid Protein in a Conformationally Trapped Unassembled State Induced by Small-Molecule Binding

(2010) Shoucheng Du et al.   JOURNAL OF MOLECULAR BIOLOGY

Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Infection by Virus Capsid Destabilization

(2010) J. Shi et al.   JOURNAL OF VIROLOGY

HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

(2010) Wade S. Blair et al.   PLoS Pathogens

X-Ray Structures of the Hexameric Building Block of the HIV Capsid

(2009) Owen Pornillos et al.   CELL

Residues in the HIV-1 Capsid Assembly Inhibitor Binding Site Are Essential for Maintaining the Assembly-competent Quaternary Structure of the Capsid Protein

(2008) Vanda Bartonova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Cell-penetrating Helical Peptide as a Potential HIV-1 Inhibitor

(2008) Hongtao Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY