Multifunctional agents based on benzoxazolone as promising therapeutic drugs for diabetic nephropathy

Synthesis of new arylsulfonylspiroimidazolidine-2ʹ,4ʹ-diones and study of their effect on stimulation of insulin release from MIN6 cell line, inhibition of human aldose reductase, sorbitol accumulations in various tissues and oxidative stress

(2019) Zafar Iqbal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5′-Adenosine Monophosphate-Activated Protein Kinase (AMPK)

(2018) David J. Edmonds et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of Dietary Sugar Intake on Biomarkers of Subclinical Inflammation: A Systematic Review and Meta-Analysis of Intervention Studies

(2018) Karen Della Corte et al.   Nutrients

The Ecstasy and Agony of Assay Interference Compounds

(2017) Courtney Aldrich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice

(2017) Ana Andres-Hernando et al.   Nature Communications

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes StatusNovelty and Significance

(2016) Amy R. Cameron et al.   CIRCULATION RESEARCH

A series of pyrido[2,3- b ]pyrazin-3(4 H )-one derivatives as aldose reductase inhibitors with antioxidant activity

(2016) Zhongfei Han et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

(2016)   NEW ENGLAND JOURNAL OF MEDICINE

Phenolic 4-hydroxy and 3,5-dihydroxy derivatives of 3-phenoxyquinoxalin-2(1H)-one as potent aldose reductase inhibitors with antioxidant activity

(2015) Yingang Zou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Therapies on the Horizon for Diabetic Kidney Disease

(2015) Sadaf S. Khan et al.   Current Diabetes Reports

Synthesis, characterization, hypoglycemic and aldose reductase inhibition activity of arylsulfonylspiro[fluorene-9,5′-imidazolidine]-2′,4′-diones

(2015) Zafar Iqbal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Empagliflozin, an Inhibitor of Sodium-Glucose Cotransporter 2 Exerts Anti-Inflammatory and Antifibrotic Effects on Experimental Diabetic Nephropathy Partly by Suppressing AGEs-Receptor Axis

(2015) A. Ojima et al.   HORMONE AND METABOLIC RESEARCH

Design and Synthesis of Potent and Multifunctional Aldose Reductase Inhibitors Based on Quinoxalinones

(2015) Xiangyu Qin et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Aggregation Advisor for Ligand Discovery

(2015) John J. Irwin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecule Adenosine 5′-Monophosphate Activated Protein Kinase (AMPK) Modulators and Human Diseases

(2014) Sandeep Rana et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and structure–activity relationships of novel benzoxazolone derivatives as 18kDa translocator protein (TSPO) ligands

(2012) Takayuki Fukaya et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dual action spirobicycloimidazolidine-2,4-diones: Antidiabetic agents and inhibitors of aldose reductase-an enzyme involved in diabetic complications

(2012) Zafar Iqbal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Olmesartan for the Delay or Prevention of Microalbuminuria in Type 2 Diabetes

(2011) Hermann Haller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: effects on glycaemic control and body weight

(2010) L. Zhang et al.   DIABETES OBESITY & METABOLISM

A Diverse Series of Substituted Benzenesulfonamides as Aldose Reductase Inhibitors with Antioxidant Activity: Design, Synthesis, and in Vitro Activity

(2010) Polyxeni Alexiou et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aldose Reductase Inhibitor, Epalrestat, Reduces Lipid Hydroperoxides in Type 2 Diabetes

(2009) Chie OHMURA et al.   ENDOCRINE JOURNAL

Prognostic value of blood pressure in patients with high vascular risk in the Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial study

(2009) Peter Sleight et al.   JOURNAL OF HYPERTENSION

Insulin inhibits tumor necrosis factor-α induction in myocardial ischemia/reperfusion: Role of Akt and endothelial nitric oxide synthase phosphorylation*

(2008) Jia Li et al.   CRITICAL CARE MEDICINE

Aldose Reductase, Still a Compelling Target for Diabetic Neuropathy

(2008) Peter Oates   CURRENT DRUG TARGETS

Decreasing Intracellular Superoxide Corrects Defective Ischemia-induced New Vessel Formation in Diabetic Mice

(2008) Daniel J. Ceradini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY